Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass. / Bojsen-Møller, Kirstine N; Dirksen, Carsten; Svane, Maria Saur; Jørgensen, Nils B; Holst, Jens Juul; Richter, Erik A.; Madsbad, Sten.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 312, No. 5, 2017, p. R797-R805.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bojsen-Møller, KN, Dirksen, C, Svane, MS, Jørgensen, NB, Holst, JJ, Richter, EA & Madsbad, S 2017, 'Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 312, no. 5, pp. R797-R805. https://doi.org/10.1152/ajpregu.00291.2016

APA

Bojsen-Møller, K. N., Dirksen, C., Svane, M. S., Jørgensen, N. B., Holst, J. J., Richter, E. A., & Madsbad, S. (2017). Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 312(5), R797-R805. https://doi.org/10.1152/ajpregu.00291.2016

Vancouver

Bojsen-Møller KN, Dirksen C, Svane MS, Jørgensen NB, Holst JJ, Richter EA et al. Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2017;312(5):R797-R805. https://doi.org/10.1152/ajpregu.00291.2016

Author

Bojsen-Møller, Kirstine N ; Dirksen, Carsten ; Svane, Maria Saur ; Jørgensen, Nils B ; Holst, Jens Juul ; Richter, Erik A. ; Madsbad, Sten. / Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2017 ; Vol. 312, No. 5. pp. R797-R805.

Bibtex

@article{3a03cbe41cee4c0b9b2bee05fab67fea,
title = "Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass",
abstract = "Roux-en-Y gastric bypass (RYGB) induces weight loss and improves insulin sensitivity when evaluated by the hyperinsulinemic-euglycemic clamp (HEC). Surrogate indices of insulin sensitivity calculated from insulin and glucose concentrations at fasting or after an oral glucose tolerance test (OGTT) are frequently used, but have not been validated after RYGB. Our aim was to evaluate whether surrogate indices reliably estimate changes in insulin sensitivity after RYGB. Four fasting (inverse-HOMA-IR, HOMA2-%S, QUICKI, revised-QUICKI) and three OGTT-derived surrogates (Matsuda, Gutt, OGIS) were compared with HEC-estimated peripheral insulin sensitivity (Rd or Rd/I, depending on how the index was originally validated) and the tracer-determined hepatic insulin sensitivity index (HISI) in patients with preoperative type 2 diabetes (n=10) and normal glucose tolerance (n=10) 1 week, 3 months and 1 year postoperatively. Post-RYGB changes in inverse-HOMA-IR and HOMA2-%S did not correlate with changes in Rd at any visit, but were comparable to changes in HISI at 1 week. Changes in QUICKI and revised-QUICKI correlated with Rd/I after surgery. Changes in Matsuda and Gutt did not correlate with changes in Rd/I and Rd, respectively, whereas OGIS-changes correlated with Rd-changes at 1 year post-RYGB. In conclusion, surrogate measures of insulin sensitivity may not reflect results obtained with gold standard methodology after RYGB, underscoring the importance of critical reflection when surrogate endpoints are used. Fasting surrogate indices may be particularly affected by post-RYGB changes in insulin clearance, whereas the validity of OGTT-derived surrogates may be compromised by the surgical rearrangements of the gut.",
keywords = "Bariatric surgery, Peripheral insulin sensitivity, Hepatic insulin sensitivity, HOMA-IR, QUICKI, Matsuda, OGIS",
author = "Bojsen-M{\o}ller, {Kirstine N} and Carsten Dirksen and Svane, {Maria Saur} and J{\o}rgensen, {Nils B} and Holst, {Jens Juul} and Richter, {Erik A.} and Sten Madsbad",
note = "CURIS 2017 NEXS 156",
year = "2017",
doi = "10.1152/ajpregu.00291.2016",
language = "English",
volume = "312",
pages = "R797--R805",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass

AU - Bojsen-Møller, Kirstine N

AU - Dirksen, Carsten

AU - Svane, Maria Saur

AU - Jørgensen, Nils B

AU - Holst, Jens Juul

AU - Richter, Erik A.

AU - Madsbad, Sten

N1 - CURIS 2017 NEXS 156

PY - 2017

Y1 - 2017

N2 - Roux-en-Y gastric bypass (RYGB) induces weight loss and improves insulin sensitivity when evaluated by the hyperinsulinemic-euglycemic clamp (HEC). Surrogate indices of insulin sensitivity calculated from insulin and glucose concentrations at fasting or after an oral glucose tolerance test (OGTT) are frequently used, but have not been validated after RYGB. Our aim was to evaluate whether surrogate indices reliably estimate changes in insulin sensitivity after RYGB. Four fasting (inverse-HOMA-IR, HOMA2-%S, QUICKI, revised-QUICKI) and three OGTT-derived surrogates (Matsuda, Gutt, OGIS) were compared with HEC-estimated peripheral insulin sensitivity (Rd or Rd/I, depending on how the index was originally validated) and the tracer-determined hepatic insulin sensitivity index (HISI) in patients with preoperative type 2 diabetes (n=10) and normal glucose tolerance (n=10) 1 week, 3 months and 1 year postoperatively. Post-RYGB changes in inverse-HOMA-IR and HOMA2-%S did not correlate with changes in Rd at any visit, but were comparable to changes in HISI at 1 week. Changes in QUICKI and revised-QUICKI correlated with Rd/I after surgery. Changes in Matsuda and Gutt did not correlate with changes in Rd/I and Rd, respectively, whereas OGIS-changes correlated with Rd-changes at 1 year post-RYGB. In conclusion, surrogate measures of insulin sensitivity may not reflect results obtained with gold standard methodology after RYGB, underscoring the importance of critical reflection when surrogate endpoints are used. Fasting surrogate indices may be particularly affected by post-RYGB changes in insulin clearance, whereas the validity of OGTT-derived surrogates may be compromised by the surgical rearrangements of the gut.

AB - Roux-en-Y gastric bypass (RYGB) induces weight loss and improves insulin sensitivity when evaluated by the hyperinsulinemic-euglycemic clamp (HEC). Surrogate indices of insulin sensitivity calculated from insulin and glucose concentrations at fasting or after an oral glucose tolerance test (OGTT) are frequently used, but have not been validated after RYGB. Our aim was to evaluate whether surrogate indices reliably estimate changes in insulin sensitivity after RYGB. Four fasting (inverse-HOMA-IR, HOMA2-%S, QUICKI, revised-QUICKI) and three OGTT-derived surrogates (Matsuda, Gutt, OGIS) were compared with HEC-estimated peripheral insulin sensitivity (Rd or Rd/I, depending on how the index was originally validated) and the tracer-determined hepatic insulin sensitivity index (HISI) in patients with preoperative type 2 diabetes (n=10) and normal glucose tolerance (n=10) 1 week, 3 months and 1 year postoperatively. Post-RYGB changes in inverse-HOMA-IR and HOMA2-%S did not correlate with changes in Rd at any visit, but were comparable to changes in HISI at 1 week. Changes in QUICKI and revised-QUICKI correlated with Rd/I after surgery. Changes in Matsuda and Gutt did not correlate with changes in Rd/I and Rd, respectively, whereas OGIS-changes correlated with Rd-changes at 1 year post-RYGB. In conclusion, surrogate measures of insulin sensitivity may not reflect results obtained with gold standard methodology after RYGB, underscoring the importance of critical reflection when surrogate endpoints are used. Fasting surrogate indices may be particularly affected by post-RYGB changes in insulin clearance, whereas the validity of OGTT-derived surrogates may be compromised by the surgical rearrangements of the gut.

KW - Bariatric surgery

KW - Peripheral insulin sensitivity

KW - Hepatic insulin sensitivity

KW - HOMA-IR

KW - QUICKI

KW - Matsuda

KW - OGIS

U2 - 10.1152/ajpregu.00291.2016

DO - 10.1152/ajpregu.00291.2016

M3 - Journal article

C2 - 28202439

VL - 312

SP - R797-R805

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 5

ER -

ID: 173508972