Time trial performance is sensitive to low-volume autologous blood transfusion

Research output: Contribution to journalJournal articlepeer-review

Standard

Time trial performance is sensitive to low-volume autologous blood transfusion. / Bejder, Jacob; Andersen, Andreas Breenfeldt; Solheim, Sara Amalie; Gybel-Brask, Mikkel; Secher, Niels H.; Johansson, Pär I; Nordsborg, Nikolai Baastrup.

In: Medicine and Science in Sports and Exercise, Vol. 51, No. 4, 2019, p. 692-700.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bejder, J, Andersen, AB, Solheim, SA, Gybel-Brask, M, Secher, NH, Johansson, PI & Nordsborg, NB 2019, 'Time trial performance is sensitive to low-volume autologous blood transfusion', Medicine and Science in Sports and Exercise, vol. 51, no. 4, pp. 692-700. https://doi.org/10.1249/MSS.0000000000001837

APA

Bejder, J., Andersen, A. B., Solheim, S. A., Gybel-Brask, M., Secher, N. H., Johansson, P. I., & Nordsborg, N. B. (2019). Time trial performance is sensitive to low-volume autologous blood transfusion. Medicine and Science in Sports and Exercise, 51(4), 692-700. https://doi.org/10.1249/MSS.0000000000001837

Vancouver

Bejder J, Andersen AB, Solheim SA, Gybel-Brask M, Secher NH, Johansson PI et al. Time trial performance is sensitive to low-volume autologous blood transfusion. Medicine and Science in Sports and Exercise. 2019;51(4):692-700. https://doi.org/10.1249/MSS.0000000000001837

Author

Bejder, Jacob ; Andersen, Andreas Breenfeldt ; Solheim, Sara Amalie ; Gybel-Brask, Mikkel ; Secher, Niels H. ; Johansson, Pär I ; Nordsborg, Nikolai Baastrup. / Time trial performance is sensitive to low-volume autologous blood transfusion. In: Medicine and Science in Sports and Exercise. 2019 ; Vol. 51, No. 4. pp. 692-700.

Bibtex

@article{1b979219e153427fa46731c1f474e5d7,
title = "Time trial performance is sensitive to low-volume autologous blood transfusion",
abstract = "Purpose: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBCs) from a standard 450 ml phlebotomy would increase mean power in a cycling time trial. Additionally, the study investigated whether further ABT of RBCs obtained from another 450 ml phlebotomy would increase repeated cycling sprint ability.Methods: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450 ml blood bags each (BT-trial) or were sham phlebotomized (PLA-trial). Four weeks later, a 650 kcal time trial (n=7) was performed three days before and 2 h after receiving either ~50% (135 ml) of the RBCs or a sham transfusion. On the following day, transfusion of RBCs (235 ml) from the second donation or sham transfusion was completed. A 4×30 s all-out cycling sprint interspersed by 4 min of recovery was performed six days before and three days after the second ABT (n=9).Results: The mean power was increased in time trials from before to after transfusion (P<0.05) in BT (213±35 vs. 223±38 W; mean±SD) but not in PLA (223±42 vs. 224±46 W). In contrast, the mean power output across the four 30 s sprint bouts remained similar in BT (639±35 vs. 644±26 W) and PLA (638±43 vs. 639±25 W).Conclusion: ABT of only ~135 ml of RBCs is sufficient to increase mean power in a 650 kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 ml of RBCs does not alter 4×30 s all-out cycling performance interspersed with 4 min of recovery.",
keywords = "Faculty of Science, Small-volume transfusion, Large-volume transfusion, Cycling, Endurance, Intermittent exercise, Doping",
author = "Jacob Bejder and Andersen, {Andreas Breenfeldt} and Solheim, {Sara Amalie} and Mikkel Gybel-Brask and Secher, {Niels H.} and Johansson, {P{\"a}r I} and Nordsborg, {Nikolai Baastrup}",
note = "CURIS 2019 NEXS 099",
year = "2019",
doi = "10.1249/MSS.0000000000001837",
language = "English",
volume = "51",
pages = "692--700",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Time trial performance is sensitive to low-volume autologous blood transfusion

AU - Bejder, Jacob

AU - Andersen, Andreas Breenfeldt

AU - Solheim, Sara Amalie

AU - Gybel-Brask, Mikkel

AU - Secher, Niels H.

AU - Johansson, Pär I

AU - Nordsborg, Nikolai Baastrup

N1 - CURIS 2019 NEXS 099

PY - 2019

Y1 - 2019

N2 - Purpose: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBCs) from a standard 450 ml phlebotomy would increase mean power in a cycling time trial. Additionally, the study investigated whether further ABT of RBCs obtained from another 450 ml phlebotomy would increase repeated cycling sprint ability.Methods: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450 ml blood bags each (BT-trial) or were sham phlebotomized (PLA-trial). Four weeks later, a 650 kcal time trial (n=7) was performed three days before and 2 h after receiving either ~50% (135 ml) of the RBCs or a sham transfusion. On the following day, transfusion of RBCs (235 ml) from the second donation or sham transfusion was completed. A 4×30 s all-out cycling sprint interspersed by 4 min of recovery was performed six days before and three days after the second ABT (n=9).Results: The mean power was increased in time trials from before to after transfusion (P<0.05) in BT (213±35 vs. 223±38 W; mean±SD) but not in PLA (223±42 vs. 224±46 W). In contrast, the mean power output across the four 30 s sprint bouts remained similar in BT (639±35 vs. 644±26 W) and PLA (638±43 vs. 639±25 W).Conclusion: ABT of only ~135 ml of RBCs is sufficient to increase mean power in a 650 kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 ml of RBCs does not alter 4×30 s all-out cycling performance interspersed with 4 min of recovery.

AB - Purpose: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBCs) from a standard 450 ml phlebotomy would increase mean power in a cycling time trial. Additionally, the study investigated whether further ABT of RBCs obtained from another 450 ml phlebotomy would increase repeated cycling sprint ability.Methods: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450 ml blood bags each (BT-trial) or were sham phlebotomized (PLA-trial). Four weeks later, a 650 kcal time trial (n=7) was performed three days before and 2 h after receiving either ~50% (135 ml) of the RBCs or a sham transfusion. On the following day, transfusion of RBCs (235 ml) from the second donation or sham transfusion was completed. A 4×30 s all-out cycling sprint interspersed by 4 min of recovery was performed six days before and three days after the second ABT (n=9).Results: The mean power was increased in time trials from before to after transfusion (P<0.05) in BT (213±35 vs. 223±38 W; mean±SD) but not in PLA (223±42 vs. 224±46 W). In contrast, the mean power output across the four 30 s sprint bouts remained similar in BT (639±35 vs. 644±26 W) and PLA (638±43 vs. 639±25 W).Conclusion: ABT of only ~135 ml of RBCs is sufficient to increase mean power in a 650 kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 ml of RBCs does not alter 4×30 s all-out cycling performance interspersed with 4 min of recovery.

KW - Faculty of Science

KW - Small-volume transfusion

KW - Large-volume transfusion

KW - Cycling

KW - Endurance

KW - Intermittent exercise

KW - Doping

U2 - 10.1249/MSS.0000000000001837

DO - 10.1249/MSS.0000000000001837

M3 - Journal article

C2 - 30407276

VL - 51

SP - 692

EP - 700

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 4

ER -

ID: 208852690