The effect of training on responses of beta-endorphin and other pituitary hormones to insulin-induced hypoglycemia
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The effect of training on responses of beta-endorphin and other pituitary hormones to insulin-induced hypoglycemia. / Mikines, K J; Kjær, Michael; Hagen, C; Sonne, B; Richter, Erik A.; Galbo, H.
In: European Journal of Applied Physiology and Occupational Physiology, Vol. 54, No. 5, 1985, p. 476-479.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of training on responses of beta-endorphin and other pituitary hormones to insulin-induced hypoglycemia
AU - Mikines, K J
AU - Kjær, Michael
AU - Hagen, C
AU - Sonne, B
AU - Richter, Erik A.
AU - Galbo, H
PY - 1985
Y1 - 1985
N2 - We studied whether the previously reported intensified beta-endorphin response to exercise after training might result from a training-induced general increase in anterior pituitary secretory capacity. Identical hypoglycemia was induced by insulin infusion in 7 untrained (VO2max 49 +/- 4 ml X (kg X min)-1, mean and SE) and 8 physically trained (VO2max 65 +/- 4 ml X (kg X min)-1) subjects. In response to hypoglycemia, levels of beta-endorphin and prolactin immunoreactivity in serum increased similarly in trained (from 41 +/- 2 pg X ml-1 and 6 +/- 1 pg X ml-1 before hypoglycemia to 103 +/- 11 pg X ml-1 and 43 +/- 9 pg X ml-1 during recovery, P less than 0.05) and untrained (from 35 +/- 7 pg X ml-1 and 7 +/- 2 pg X ml-1 to 113 +/- 18 pg X ml-1 and 31 +/- 8 pg X ml-1, P less than 0.05) subjects. Growth hormone (GH) was higher 90 min after glucose nadir in trained (61 +/- 13 mU X l-1) than in untrained (25 +/- 6 mU X l-1) subjects (P less than 0.05). Levels of thyrotropin (TSH) changed in neither of the groups. It is concluded that, in contrast to what has been formerly proposed, training does not result in a general increase in secretory capacity of the anterior pituitary gland. TSH responds to hypoglycemia neither in trained nor in untrained subjects. Finally, differences in beta-endorphin responses to exercise between trained and untrained subjects cannot be ascribed to differences in responsiveness to hypoglycemia.
AB - We studied whether the previously reported intensified beta-endorphin response to exercise after training might result from a training-induced general increase in anterior pituitary secretory capacity. Identical hypoglycemia was induced by insulin infusion in 7 untrained (VO2max 49 +/- 4 ml X (kg X min)-1, mean and SE) and 8 physically trained (VO2max 65 +/- 4 ml X (kg X min)-1) subjects. In response to hypoglycemia, levels of beta-endorphin and prolactin immunoreactivity in serum increased similarly in trained (from 41 +/- 2 pg X ml-1 and 6 +/- 1 pg X ml-1 before hypoglycemia to 103 +/- 11 pg X ml-1 and 43 +/- 9 pg X ml-1 during recovery, P less than 0.05) and untrained (from 35 +/- 7 pg X ml-1 and 7 +/- 2 pg X ml-1 to 113 +/- 18 pg X ml-1 and 31 +/- 8 pg X ml-1, P less than 0.05) subjects. Growth hormone (GH) was higher 90 min after glucose nadir in trained (61 +/- 13 mU X l-1) than in untrained (25 +/- 6 mU X l-1) subjects (P less than 0.05). Levels of thyrotropin (TSH) changed in neither of the groups. It is concluded that, in contrast to what has been formerly proposed, training does not result in a general increase in secretory capacity of the anterior pituitary gland. TSH responds to hypoglycemia neither in trained nor in untrained subjects. Finally, differences in beta-endorphin responses to exercise between trained and untrained subjects cannot be ascribed to differences in responsiveness to hypoglycemia.
KW - Adult
KW - Blood Glucose
KW - Endorphins
KW - Growth Hormone
KW - Humans
KW - Insulin
KW - Male
KW - Physical Education and Training
KW - Pituitary Hormones
KW - Prolactin
KW - Thyrotropin
KW - beta-Endorphin
M3 - Journal article
C2 - 2935392
VL - 54
SP - 476
EP - 479
JO - European Journal of Applied Physiology and Occupational Physiology
JF - European Journal of Applied Physiology and Occupational Physiology
SN - 0301-5548
IS - 5
ER -
ID: 154759125