Significance of insulin for glucose metabolism in skeletal muscle during contractions
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Significance of insulin for glucose metabolism in skeletal muscle during contractions. / Hespel, P; Vergauwen, Lieven; Vandenberghe, K; Richter, Erik A.
In: Diabetes, Vol. 45, No. Suppl. 1, 1996, p. S99-S104.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Significance of insulin for glucose metabolism in skeletal muscle during contractions
AU - Hespel, P
AU - Vergauwen, Lieven
AU - Vandenberghe, K
AU - Richter, Erik A.
PY - 1996
Y1 - 1996
N2 - Glucose uptake rate in active skeletal muscles is markedly increased during exercise. This increase reflects a multifactorial process involving both local and systemic mechanisms that cooperate to stimulate glucose extraction and glucose delivery to the muscle cells. Increased glucose extraction is effected primarily via mechanisms exerted within the muscle cell related to the contractile activity per se. Yet contractions become a more potent stimulus of muscle glucose uptake as the plasma insulin level is increased. In addition, enhanced glucose delivery to muscle, which during exercise is essentially effected via increased blood flow, significantly contributes to stimulate glucose uptake. Again, however, increased glucose delivery appears to be a more potent stimulus of muscle glucose uptake as the circulating insulin level is increased. Furthermore, contractions and elevated flow prove to be additive stimuli of muscle glucose uptake at any plasma insulin level. In conclusion, the extent to which muscle glucose uptake is stimulated during exercise depends on various factors, including 1) the intensity of the contractile activity, 2) the magnitude of the exercise-associated increase in muscle blood flow, and 3) the circulating insulin level.
AB - Glucose uptake rate in active skeletal muscles is markedly increased during exercise. This increase reflects a multifactorial process involving both local and systemic mechanisms that cooperate to stimulate glucose extraction and glucose delivery to the muscle cells. Increased glucose extraction is effected primarily via mechanisms exerted within the muscle cell related to the contractile activity per se. Yet contractions become a more potent stimulus of muscle glucose uptake as the plasma insulin level is increased. In addition, enhanced glucose delivery to muscle, which during exercise is essentially effected via increased blood flow, significantly contributes to stimulate glucose uptake. Again, however, increased glucose delivery appears to be a more potent stimulus of muscle glucose uptake as the circulating insulin level is increased. Furthermore, contractions and elevated flow prove to be additive stimuli of muscle glucose uptake at any plasma insulin level. In conclusion, the extent to which muscle glucose uptake is stimulated during exercise depends on various factors, including 1) the intensity of the contractile activity, 2) the magnitude of the exercise-associated increase in muscle blood flow, and 3) the circulating insulin level.
KW - Adenosine
KW - Animals
KW - Biological Transport
KW - Glucose
KW - Insulin
KW - Muscle Contraction
KW - Muscles
KW - Rats
KW - Receptors, Purinergic P1
KW - Regional Blood Flow
M3 - Review
C2 - 8529809
VL - 45
SP - S99-S104
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - Suppl. 1
ER -
ID: 154751287