Role of epinephrine for muscular glycogenolysis and pancreatic hormonal secretion in running rats
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Role of epinephrine for muscular glycogenolysis and pancreatic hormonal secretion in running rats. / Richter, Erik A.; Sonne, B; Christensen, N J; Galbo, H.
In: American Journal of Physiology (Consolidated), Vol. 240, No. 5, 1981, p. E526-E532.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Role of epinephrine for muscular glycogenolysis and pancreatic hormonal secretion in running rats
AU - Richter, Erik A.
AU - Sonne, B
AU - Christensen, N J
AU - Galbo, H
PY - 1981
Y1 - 1981
N2 - We have previously shown that during swimming muscular glycogen breakdown was diminished and plasma glucagon and insulin were lower and higher, respectively, in adrenodemedullated rats compared to controls. These findings might be due to a lower work intensity or higher efficiency in adrenodemedullated rats than in controls. Furthermore, they might be due to either an acute or a chronic influence of epinephrine. Rats were adrenodemedullated (DM) or sham-operated (C). They were chronically cannulated and either rested or ran in a metabolism chamber for 45 min. Running DM rats had either saline (DM-S) or epinephrine (normalizing the concentration in plasma) (DM-E) infused. During running, oxygen uptake was identical in C and DM rats. Muscular glycogen breakdown was similar in DM-E and C rats and higher than in DM-S rats. Blood glucose, lactate, and heart rate increased in C and DM-E, but not in DM-S rats. In spite of the differences in blood glucose, plasma insulin was the same in all groups and plasma glucagon increased identically in all running rats. Plasma FFA and liver glycogen were similar in all groups. In conclusion. in running rats, epinephrine exerts an acute enhancing effect on muscular glycogenolysis, glucagon secretion, and heart rate and an acute depressing effect on insulin secretion.
AB - We have previously shown that during swimming muscular glycogen breakdown was diminished and plasma glucagon and insulin were lower and higher, respectively, in adrenodemedullated rats compared to controls. These findings might be due to a lower work intensity or higher efficiency in adrenodemedullated rats than in controls. Furthermore, they might be due to either an acute or a chronic influence of epinephrine. Rats were adrenodemedullated (DM) or sham-operated (C). They were chronically cannulated and either rested or ran in a metabolism chamber for 45 min. Running DM rats had either saline (DM-S) or epinephrine (normalizing the concentration in plasma) (DM-E) infused. During running, oxygen uptake was identical in C and DM rats. Muscular glycogen breakdown was similar in DM-E and C rats and higher than in DM-S rats. Blood glucose, lactate, and heart rate increased in C and DM-E, but not in DM-S rats. In spite of the differences in blood glucose, plasma insulin was the same in all groups and plasma glucagon increased identically in all running rats. Plasma FFA and liver glycogen were similar in all groups. In conclusion. in running rats, epinephrine exerts an acute enhancing effect on muscular glycogenolysis, glucagon secretion, and heart rate and an acute depressing effect on insulin secretion.
KW - Adrenal Medulla
KW - Animals
KW - Blood Glucose
KW - Epinephrine
KW - Glucagon
KW - Glycogen
KW - Insulin
KW - Male
KW - Muscles
KW - Physical Exertion
KW - Rats
M3 - Journal article
C2 - 7015878
VL - 240
SP - E526-E532
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 5
ER -
ID: 154760375