No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm

Research output: Contribution to journalJournal articlepeer-review

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No trace of phase : Corticomotor excitability is not tuned by phase of pericentral mu-rhythm. / Madsen, Kristoffer Hougaard; Karabanov, Anke Ninija; Krohne, Lærke Gebser; Safeldt, Mads Gylling; Tomasevic, Leo; Siebner, Hartwig Roman.

In: Brain Stimulation, Vol. 12, No. 5, 2019, p. 1261-1270.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Madsen, KH, Karabanov, AN, Krohne, LG, Safeldt, MG, Tomasevic, L & Siebner, HR 2019, 'No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm', Brain Stimulation, vol. 12, no. 5, pp. 1261-1270. https://doi.org/10.1016/j.brs.2019.05.005

APA

Madsen, K. H., Karabanov, A. N., Krohne, L. G., Safeldt, M. G., Tomasevic, L., & Siebner, H. R. (2019). No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm. Brain Stimulation, 12(5), 1261-1270. https://doi.org/10.1016/j.brs.2019.05.005

Vancouver

Madsen KH, Karabanov AN, Krohne LG, Safeldt MG, Tomasevic L, Siebner HR. No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm. Brain Stimulation. 2019;12(5):1261-1270. https://doi.org/10.1016/j.brs.2019.05.005

Author

Madsen, Kristoffer Hougaard ; Karabanov, Anke Ninija ; Krohne, Lærke Gebser ; Safeldt, Mads Gylling ; Tomasevic, Leo ; Siebner, Hartwig Roman. / No trace of phase : Corticomotor excitability is not tuned by phase of pericentral mu-rhythm. In: Brain Stimulation. 2019 ; Vol. 12, No. 5. pp. 1261-1270.

Bibtex

@article{112c0828090a44d0a5f6fa61cfdb2c5c,
title = "No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm",
abstract = "Background: The motor potentials evoked by transcranial magnetic stimulation (TMS) over the motor hand area (M1-HAND) show substantial inter-trial variability. Pericentral mu-rhythm oscillations, might contribute to inter-trial variability. Recent studies targeting mu-activity based on real-time electroencephalography (EEG) reported an influence of mu-power and mu-phase on the amplitude of motor evoked potentials (MEPs) in a preselected group with strong pericentral mu-activity. Other studies that determined mu-power or mu-phase based on post-hoc trial sorting according in non-preselected individuals were largely negative. Objectives: To reassess if cortico-spinal activity is modulated by the mu-rhythm, we applied single-pulse TMS to the M1-HAND conditional on the phase of the intrinsically expressed pericentral mu-rhythm in 14 non-preselected healthy young participants. Methods: TMS was given at 0, 90, 180, and 270° of the mu-phase. Based on the absence of effects of mu-phase or mu-power when analyzing the mean MEP amplitudes, we also computed a linear mixed effects model, which included mu-phase, mu-power, inter-stimulus interval (ISIs) as fixed effects, treating the subject factor as a random effect. Results: Mixed model analysis revealed a significant effect of mu-power and ISI, but no effect of mu-phase and no interactions. MEP amplitude scaled linearly with lower mu-power or longer ISIs, but these modulatory effects were very small relative to inter-trial MEP variability. Conclusion: Our largely negative results are in agreement with previous offline TMS-EEG studies and point to a possible influence of ISI. Future research needs to clarify under which circumstances the responsiveness of human the M1-HAND to TMS depends on the synchronicity with mu-power and mu-phase.",
keywords = "EEG-Triggered phase targeting, Electroencephalography, Mu rhythm, Pericentral oscillation, Temporal and spatial neuronavigation, Transcranial magnetic stimulation",
author = "Madsen, {Kristoffer Hougaard} and Karabanov, {Anke Ninija} and Krohne, {L{\ae}rke Gebser} and Safeldt, {Mads Gylling} and Leo Tomasevic and Siebner, {Hartwig Roman}",
note = "(Ekstern)",
year = "2019",
doi = "10.1016/j.brs.2019.05.005",
language = "English",
volume = "12",
pages = "1261--1270",
journal = "Brain Stimulation",
issn = "1935-861X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - No trace of phase

T2 - Corticomotor excitability is not tuned by phase of pericentral mu-rhythm

AU - Madsen, Kristoffer Hougaard

AU - Karabanov, Anke Ninija

AU - Krohne, Lærke Gebser

AU - Safeldt, Mads Gylling

AU - Tomasevic, Leo

AU - Siebner, Hartwig Roman

N1 - (Ekstern)

PY - 2019

Y1 - 2019

N2 - Background: The motor potentials evoked by transcranial magnetic stimulation (TMS) over the motor hand area (M1-HAND) show substantial inter-trial variability. Pericentral mu-rhythm oscillations, might contribute to inter-trial variability. Recent studies targeting mu-activity based on real-time electroencephalography (EEG) reported an influence of mu-power and mu-phase on the amplitude of motor evoked potentials (MEPs) in a preselected group with strong pericentral mu-activity. Other studies that determined mu-power or mu-phase based on post-hoc trial sorting according in non-preselected individuals were largely negative. Objectives: To reassess if cortico-spinal activity is modulated by the mu-rhythm, we applied single-pulse TMS to the M1-HAND conditional on the phase of the intrinsically expressed pericentral mu-rhythm in 14 non-preselected healthy young participants. Methods: TMS was given at 0, 90, 180, and 270° of the mu-phase. Based on the absence of effects of mu-phase or mu-power when analyzing the mean MEP amplitudes, we also computed a linear mixed effects model, which included mu-phase, mu-power, inter-stimulus interval (ISIs) as fixed effects, treating the subject factor as a random effect. Results: Mixed model analysis revealed a significant effect of mu-power and ISI, but no effect of mu-phase and no interactions. MEP amplitude scaled linearly with lower mu-power or longer ISIs, but these modulatory effects were very small relative to inter-trial MEP variability. Conclusion: Our largely negative results are in agreement with previous offline TMS-EEG studies and point to a possible influence of ISI. Future research needs to clarify under which circumstances the responsiveness of human the M1-HAND to TMS depends on the synchronicity with mu-power and mu-phase.

AB - Background: The motor potentials evoked by transcranial magnetic stimulation (TMS) over the motor hand area (M1-HAND) show substantial inter-trial variability. Pericentral mu-rhythm oscillations, might contribute to inter-trial variability. Recent studies targeting mu-activity based on real-time electroencephalography (EEG) reported an influence of mu-power and mu-phase on the amplitude of motor evoked potentials (MEPs) in a preselected group with strong pericentral mu-activity. Other studies that determined mu-power or mu-phase based on post-hoc trial sorting according in non-preselected individuals were largely negative. Objectives: To reassess if cortico-spinal activity is modulated by the mu-rhythm, we applied single-pulse TMS to the M1-HAND conditional on the phase of the intrinsically expressed pericentral mu-rhythm in 14 non-preselected healthy young participants. Methods: TMS was given at 0, 90, 180, and 270° of the mu-phase. Based on the absence of effects of mu-phase or mu-power when analyzing the mean MEP amplitudes, we also computed a linear mixed effects model, which included mu-phase, mu-power, inter-stimulus interval (ISIs) as fixed effects, treating the subject factor as a random effect. Results: Mixed model analysis revealed a significant effect of mu-power and ISI, but no effect of mu-phase and no interactions. MEP amplitude scaled linearly with lower mu-power or longer ISIs, but these modulatory effects were very small relative to inter-trial MEP variability. Conclusion: Our largely negative results are in agreement with previous offline TMS-EEG studies and point to a possible influence of ISI. Future research needs to clarify under which circumstances the responsiveness of human the M1-HAND to TMS depends on the synchronicity with mu-power and mu-phase.

KW - EEG-Triggered phase targeting

KW - Electroencephalography

KW - Mu rhythm

KW - Pericentral oscillation

KW - Temporal and spatial neuronavigation

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=85066075278&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2019.05.005

DO - 10.1016/j.brs.2019.05.005

M3 - Journal article

C2 - 31133479

AN - SCOPUS:85066075278

VL - 12

SP - 1261

EP - 1270

JO - Brain Stimulation

JF - Brain Stimulation

SN - 1935-861X

IS - 5

ER -

ID: 227129593