Muscle glycogenolysis during exercise: dual control by epinephrine and contractions

Research output: Contribution to journalJournal articlepeer-review

Standard

Muscle glycogenolysis during exercise : dual control by epinephrine and contractions. / Richter, Erik A.; Ruderman, N B; Gavras, H; Belur, E R; Galbo, H.

In: American Journal of Physiology, Vol. 242, No. 1, 1982, p. E25-E32.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Richter, EA, Ruderman, NB, Gavras, H, Belur, ER & Galbo, H 1982, 'Muscle glycogenolysis during exercise: dual control by epinephrine and contractions', American Journal of Physiology, vol. 242, no. 1, pp. E25-E32.

APA

Richter, E. A., Ruderman, N. B., Gavras, H., Belur, E. R., & Galbo, H. (1982). Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. American Journal of Physiology, 242(1), E25-E32.

Vancouver

Richter EA, Ruderman NB, Gavras H, Belur ER, Galbo H. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. American Journal of Physiology. 1982;242(1):E25-E32.

Author

Richter, Erik A. ; Ruderman, N B ; Gavras, H ; Belur, E R ; Galbo, H. / Muscle glycogenolysis during exercise : dual control by epinephrine and contractions. In: American Journal of Physiology. 1982 ; Vol. 242, No. 1. pp. E25-E32.

Bibtex

@article{d778b4fa40fe44199a20152b9e8ae92d,
title = "Muscle glycogenolysis during exercise: dual control by epinephrine and contractions",
abstract = "The interaction of epinephrine and contractions on muscle metabolism was studied in the isolated perfused rat hindquarter. Subtetanic contractions (180/min) through 20 min elicited glycogenolysis and increased phosphorylase a activity. In the soleus, a slow-twitch red muscle, these effects were transient, but when epinephrine at a physiological concentration (2.4 X 10(-8) M) was added to the perfusate, glycogenolysis and phosphorylase activity were sustained throughout contractions. At this high frequency of contractions, the effect of epinephrine was much smaller in the fast-twitch red fibers and not significant in the fast-twitch white fibers of the gastrocnemius muscle. However, during less frequent contractions (30/min) epinephrine increased glycogenolysis and phosphorylase a activity in fast-twitch muscle. The data suggest that epinephrine and muscle contractions exert a dual control of muscle glycogenolysis during exercise: contractions principally stimulate glycogenolysis early in exercise, and a direct effect of epinephrine on muscle is needed for continued glycogenolysis. In addition, epinephrine increased oxygen consumption and glucose uptake in both resting and electrically stimulated hindquarters and, under some conditions, it had a positive inotropic effect on contracting muscle.",
keywords = "Adenosine Triphosphate, Animals, Electric Stimulation, Epinephrine, Glycogen, Male, Muscle Contraction, Muscles, Norepinephrine, Oxygen Consumption, Perfusion, Phosphocreatine, Rats, Rats, Inbred Strains",
author = "Richter, {Erik A.} and Ruderman, {N B} and H Gavras and Belur, {E R} and H Galbo",
year = "1982",
language = "English",
volume = "242",
pages = "E25--E32",
journal = "American Journal of Physiology - Cell Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Muscle glycogenolysis during exercise

T2 - dual control by epinephrine and contractions

AU - Richter, Erik A.

AU - Ruderman, N B

AU - Gavras, H

AU - Belur, E R

AU - Galbo, H

PY - 1982

Y1 - 1982

N2 - The interaction of epinephrine and contractions on muscle metabolism was studied in the isolated perfused rat hindquarter. Subtetanic contractions (180/min) through 20 min elicited glycogenolysis and increased phosphorylase a activity. In the soleus, a slow-twitch red muscle, these effects were transient, but when epinephrine at a physiological concentration (2.4 X 10(-8) M) was added to the perfusate, glycogenolysis and phosphorylase activity were sustained throughout contractions. At this high frequency of contractions, the effect of epinephrine was much smaller in the fast-twitch red fibers and not significant in the fast-twitch white fibers of the gastrocnemius muscle. However, during less frequent contractions (30/min) epinephrine increased glycogenolysis and phosphorylase a activity in fast-twitch muscle. The data suggest that epinephrine and muscle contractions exert a dual control of muscle glycogenolysis during exercise: contractions principally stimulate glycogenolysis early in exercise, and a direct effect of epinephrine on muscle is needed for continued glycogenolysis. In addition, epinephrine increased oxygen consumption and glucose uptake in both resting and electrically stimulated hindquarters and, under some conditions, it had a positive inotropic effect on contracting muscle.

AB - The interaction of epinephrine and contractions on muscle metabolism was studied in the isolated perfused rat hindquarter. Subtetanic contractions (180/min) through 20 min elicited glycogenolysis and increased phosphorylase a activity. In the soleus, a slow-twitch red muscle, these effects were transient, but when epinephrine at a physiological concentration (2.4 X 10(-8) M) was added to the perfusate, glycogenolysis and phosphorylase activity were sustained throughout contractions. At this high frequency of contractions, the effect of epinephrine was much smaller in the fast-twitch red fibers and not significant in the fast-twitch white fibers of the gastrocnemius muscle. However, during less frequent contractions (30/min) epinephrine increased glycogenolysis and phosphorylase a activity in fast-twitch muscle. The data suggest that epinephrine and muscle contractions exert a dual control of muscle glycogenolysis during exercise: contractions principally stimulate glycogenolysis early in exercise, and a direct effect of epinephrine on muscle is needed for continued glycogenolysis. In addition, epinephrine increased oxygen consumption and glucose uptake in both resting and electrically stimulated hindquarters and, under some conditions, it had a positive inotropic effect on contracting muscle.

KW - Adenosine Triphosphate

KW - Animals

KW - Electric Stimulation

KW - Epinephrine

KW - Glycogen

KW - Male

KW - Muscle Contraction

KW - Muscles

KW - Norepinephrine

KW - Oxygen Consumption

KW - Perfusion

KW - Phosphocreatine

KW - Rats

KW - Rats, Inbred Strains

M3 - Journal article

C2 - 7058885

VL - 242

SP - E25-E32

JO - American Journal of Physiology - Cell Physiology

JF - American Journal of Physiology - Cell Physiology

SN - 0363-6143

IS - 1

ER -

ID: 154760186