Mechanisms preserving insulin action during high dietary fat intake

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mechanisms preserving insulin action during high dietary fat intake. / Lundsgaard, Annemarie; Holm, Jacob Bak; Sjøberg, Kim Anker; Bojsen-Møller, Kirstine N; Myrmel, Lene S; Fjære, Even; Jensen, Benjamin Anderschou Holbech; Nicolaisen, Trine Sand; Hingst, Janne Rasmuss; Hansen, Sine L; Doll, Sophia; Geyer, Philip E; Deshmukh, Atul Shahaji; Holst, Jens Juul; Madsen, Lise; Kristiansen, Karsten; Wojtaszewski, Jørgen; Richter, Erik A.; Kiens, Bente.

In: Cell Metabolism, Vol. 29, No. 1, 2019, p. 50-63, e1-e4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lundsgaard, A, Holm, JB, Sjøberg, KA, Bojsen-Møller, KN, Myrmel, LS, Fjære, E, Jensen, BAH, Nicolaisen, TS, Hingst, JR, Hansen, SL, Doll, S, Geyer, PE, Deshmukh, AS, Holst, JJ, Madsen, L, Kristiansen, K, Wojtaszewski, J, Richter, EA & Kiens, B 2019, 'Mechanisms preserving insulin action during high dietary fat intake', Cell Metabolism, vol. 29, no. 1, pp. 50-63, e1-e4. https://doi.org/10.1016/j.cmet.2018.08.022

APA

Lundsgaard, A., Holm, J. B., Sjøberg, K. A., Bojsen-Møller, K. N., Myrmel, L. S., Fjære, E., Jensen, B. A. H., Nicolaisen, T. S., Hingst, J. R., Hansen, S. L., Doll, S., Geyer, P. E., Deshmukh, A. S., Holst, J. J., Madsen, L., Kristiansen, K., Wojtaszewski, J., Richter, E. A., & Kiens, B. (2019). Mechanisms preserving insulin action during high dietary fat intake. Cell Metabolism, 29(1), 50-63, e1-e4. https://doi.org/10.1016/j.cmet.2018.08.022

Vancouver

Lundsgaard A, Holm JB, Sjøberg KA, Bojsen-Møller KN, Myrmel LS, Fjære E et al. Mechanisms preserving insulin action during high dietary fat intake. Cell Metabolism. 2019;29(1):50-63, e1-e4. https://doi.org/10.1016/j.cmet.2018.08.022

Author

Lundsgaard, Annemarie ; Holm, Jacob Bak ; Sjøberg, Kim Anker ; Bojsen-Møller, Kirstine N ; Myrmel, Lene S ; Fjære, Even ; Jensen, Benjamin Anderschou Holbech ; Nicolaisen, Trine Sand ; Hingst, Janne Rasmuss ; Hansen, Sine L ; Doll, Sophia ; Geyer, Philip E ; Deshmukh, Atul Shahaji ; Holst, Jens Juul ; Madsen, Lise ; Kristiansen, Karsten ; Wojtaszewski, Jørgen ; Richter, Erik A. ; Kiens, Bente. / Mechanisms preserving insulin action during high dietary fat intake. In: Cell Metabolism. 2019 ; Vol. 29, No. 1. pp. 50-63, e1-e4.

Bibtex

@article{ea4500c751bd4a2dbcede1827fdbae30,
title = "Mechanisms preserving insulin action during high dietary fat intake",
abstract = "Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly overweight men ingested saturated or polyunsaturated fat-rich diets for 6 weeks during weight maintenance. Hyperinsulinemic clamps combined with leg balance technique revealed unchanged peripheral insulin sensitivity, independent of fatty acid type. Both diets increased fat oxidation potential in muscle. Hepatic insulin clearance increased, while glucose production, de novo lipogenesis, and plasma triacylglycerol decreased. High fat intake changed the plasma proteome in the immune-supporting direction and the gut microbiome displayed changes at taxonomical and functional level with polyunsaturated fatty acid (PUFA). In mice, eucaloric feeding of human PUFA and saturated fatty acid diets lowered hepatic triacylglycerol content compared with low-fat-fed control mice, and induced adaptations in the liver supportive of decreased gluconeogenesis and lipogenesis. Intake of fat-rich diets thus induces extensive metabolic adaptations enabling disposition of dietary fat without metabolic complications.",
author = "Annemarie Lundsgaard and Holm, {Jacob Bak} and Sj{\o}berg, {Kim Anker} and Bojsen-M{\o}ller, {Kirstine N} and Myrmel, {Lene S} and Even Fj{\ae}re and Jensen, {Benjamin Anderschou Holbech} and Nicolaisen, {Trine Sand} and Hingst, {Janne Rasmuss} and Hansen, {Sine L} and Sophia Doll and Geyer, {Philip E} and Deshmukh, {Atul Shahaji} and Holst, {Jens Juul} and Lise Madsen and Karsten Kristiansen and J{\o}rgen Wojtaszewski and Richter, {Erik A.} and Bente Kiens",
note = "A correction to this publication has been published at: https://doi.org/10.1016/j.cmet.2018.10.002",
year = "2019",
doi = "10.1016/j.cmet.2018.08.022",
language = "English",
volume = "29",
pages = "50--63, e1--e4",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Mechanisms preserving insulin action during high dietary fat intake

AU - Lundsgaard, Annemarie

AU - Holm, Jacob Bak

AU - Sjøberg, Kim Anker

AU - Bojsen-Møller, Kirstine N

AU - Myrmel, Lene S

AU - Fjære, Even

AU - Jensen, Benjamin Anderschou Holbech

AU - Nicolaisen, Trine Sand

AU - Hingst, Janne Rasmuss

AU - Hansen, Sine L

AU - Doll, Sophia

AU - Geyer, Philip E

AU - Deshmukh, Atul Shahaji

AU - Holst, Jens Juul

AU - Madsen, Lise

AU - Kristiansen, Karsten

AU - Wojtaszewski, Jørgen

AU - Richter, Erik A.

AU - Kiens, Bente

N1 - A correction to this publication has been published at: https://doi.org/10.1016/j.cmet.2018.10.002

PY - 2019

Y1 - 2019

N2 - Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly overweight men ingested saturated or polyunsaturated fat-rich diets for 6 weeks during weight maintenance. Hyperinsulinemic clamps combined with leg balance technique revealed unchanged peripheral insulin sensitivity, independent of fatty acid type. Both diets increased fat oxidation potential in muscle. Hepatic insulin clearance increased, while glucose production, de novo lipogenesis, and plasma triacylglycerol decreased. High fat intake changed the plasma proteome in the immune-supporting direction and the gut microbiome displayed changes at taxonomical and functional level with polyunsaturated fatty acid (PUFA). In mice, eucaloric feeding of human PUFA and saturated fatty acid diets lowered hepatic triacylglycerol content compared with low-fat-fed control mice, and induced adaptations in the liver supportive of decreased gluconeogenesis and lipogenesis. Intake of fat-rich diets thus induces extensive metabolic adaptations enabling disposition of dietary fat without metabolic complications.

AB - Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly overweight men ingested saturated or polyunsaturated fat-rich diets for 6 weeks during weight maintenance. Hyperinsulinemic clamps combined with leg balance technique revealed unchanged peripheral insulin sensitivity, independent of fatty acid type. Both diets increased fat oxidation potential in muscle. Hepatic insulin clearance increased, while glucose production, de novo lipogenesis, and plasma triacylglycerol decreased. High fat intake changed the plasma proteome in the immune-supporting direction and the gut microbiome displayed changes at taxonomical and functional level with polyunsaturated fatty acid (PUFA). In mice, eucaloric feeding of human PUFA and saturated fatty acid diets lowered hepatic triacylglycerol content compared with low-fat-fed control mice, and induced adaptations in the liver supportive of decreased gluconeogenesis and lipogenesis. Intake of fat-rich diets thus induces extensive metabolic adaptations enabling disposition of dietary fat without metabolic complications.

U2 - 10.1016/j.cmet.2018.08.022

DO - 10.1016/j.cmet.2018.08.022

M3 - Journal article

C2 - 30269983

VL - 29

SP - 50-63, e1-e4

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

ID: 203561036