Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol

Research output: Contribution to journalJournal articlepeer-review

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Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol. / Ahmed, Sana; PrayGod, George; Lee, Nanette R; Kelly, Paul; Trilok-Kumar, Geeta; Chisenga, Molly; Kweka, Belinda; Faurholt-Jepsen, Daniel; Krogh-Madsen, Rikke; Shaw, James A M; Paglinawan-Modoc, Dixi M; Solon, Juan; Olsen, Mette Frahm; Stefanovski, Darko; Cox, Sharon; Nitsch, Dorothea; Keogh, Ruth; Filteau, Suzanne.

In: F1000Research, Vol. 11, 777, 2022.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ahmed, S, PrayGod, G, Lee, NR, Kelly, P, Trilok-Kumar, G, Chisenga, M, Kweka, B, Faurholt-Jepsen, D, Krogh-Madsen, R, Shaw, JAM, Paglinawan-Modoc, DM, Solon, J, Olsen, MF, Stefanovski, D, Cox, S, Nitsch, D, Keogh, R & Filteau, S 2022, 'Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol', F1000Research, vol. 11, 777. https://doi.org/10.12688/f1000research.123389.2

APA

Ahmed, S., PrayGod, G., Lee, N. R., Kelly, P., Trilok-Kumar, G., Chisenga, M., Kweka, B., Faurholt-Jepsen, D., Krogh-Madsen, R., Shaw, J. A. M., Paglinawan-Modoc, D. M., Solon, J., Olsen, M. F., Stefanovski, D., Cox, S., Nitsch, D., Keogh, R., & Filteau, S. (2022). Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol. F1000Research, 11, [777]. https://doi.org/10.12688/f1000research.123389.2

Vancouver

Ahmed S, PrayGod G, Lee NR, Kelly P, Trilok-Kumar G, Chisenga M et al. Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol. F1000Research. 2022;11. 777. https://doi.org/10.12688/f1000research.123389.2

Author

Ahmed, Sana ; PrayGod, George ; Lee, Nanette R ; Kelly, Paul ; Trilok-Kumar, Geeta ; Chisenga, Molly ; Kweka, Belinda ; Faurholt-Jepsen, Daniel ; Krogh-Madsen, Rikke ; Shaw, James A M ; Paglinawan-Modoc, Dixi M ; Solon, Juan ; Olsen, Mette Frahm ; Stefanovski, Darko ; Cox, Sharon ; Nitsch, Dorothea ; Keogh, Ruth ; Filteau, Suzanne. / Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol. In: F1000Research. 2022 ; Vol. 11.

Bibtex

@article{d26fd506f98f4a92baa46b951443d7c5,
title = "Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol",
abstract = "Background: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition and NCD aetiology, may not fully recover following malnutrition. However, the evidence and mechanistic information is piecemeal. We hypothesise that wasting malnutrition at any age has long-term detrimental effects on endocrine and exocrine pancreatic structure and function. Methods: The SAMPA international research programme will assess pancreatic structure and function in 3700 participants from ongoing observational nutrition cohorts, two adolescent and four adult, in Zambia, Tanzania, Philippines, and India. Pancreas size, structure, and calcification will be assessed by ultrasound and computed tomography (CT) scan; exocrine function by faecal elastase and serum lipase; and endocrine function by haemoglobin A1c (HbA1c) and blood glucose, insulin and C-peptide concentrations during an oral glucose tolerance test (OGTT). In-depth hormonal analyses of incretins, glucagon, proinsulin and trypsinogen during OGTT and intravenous glucose tolerance tests will be done in subsets of adult participants. Pancreatic size and function outcomes will be compared between people with and without prior wasting malnutrition. Analyses will investigate effect modification by sex, current age, time since malnutrition, current body mass index and dietary patterns. Mathematical modelling of OGTT data will be used to estimate the relative contribution to glucose dysregulation of decreased insulin production, changes in insulin clearance and increased insulin resistance. Proinsulin/insulin ratio will be analysed in archived samples from the Tanzanian cohort using a nested case-control design to investigate whether abnormal values precede diabetes. Conclusions: SAMPA, a large-scale multi-centre research programme using data from people with or without prior wasting malnutrition to assess several aspects of pancreatic phenotype, will provide coherent evidence for future policies and programmes for malnutrition and diabetes.",
keywords = "Faculty of Science, Malnutrition, Wasting, Diabetes, Pancreas, Non-communicable diseases, Oral glucose tolerance test",
author = "Sana Ahmed and George PrayGod and Lee, {Nanette R} and Paul Kelly and Geeta Trilok-Kumar and Molly Chisenga and Belinda Kweka and Daniel Faurholt-Jepsen and Rikke Krogh-Madsen and Shaw, {James A M} and Paglinawan-Modoc, {Dixi M} and Juan Solon and Olsen, {Mette Frahm} and Darko Stefanovski and Sharon Cox and Dorothea Nitsch and Ruth Keogh and Suzanne Filteau",
note = "CURIS 2022 NEXS 265",
year = "2022",
doi = "10.12688/f1000research.123389.2",
language = "English",
volume = "11",
journal = "F1000Research",
issn = "2046-1402",
publisher = "F1000Research",

}

RIS

TY - JOUR

T1 - Long-term health after Severe Acute Malnutrition in children and adults - the role of the Pancreas (SAMPA): Protocol

AU - Ahmed, Sana

AU - PrayGod, George

AU - Lee, Nanette R

AU - Kelly, Paul

AU - Trilok-Kumar, Geeta

AU - Chisenga, Molly

AU - Kweka, Belinda

AU - Faurholt-Jepsen, Daniel

AU - Krogh-Madsen, Rikke

AU - Shaw, James A M

AU - Paglinawan-Modoc, Dixi M

AU - Solon, Juan

AU - Olsen, Mette Frahm

AU - Stefanovski, Darko

AU - Cox, Sharon

AU - Nitsch, Dorothea

AU - Keogh, Ruth

AU - Filteau, Suzanne

N1 - CURIS 2022 NEXS 265

PY - 2022

Y1 - 2022

N2 - Background: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition and NCD aetiology, may not fully recover following malnutrition. However, the evidence and mechanistic information is piecemeal. We hypothesise that wasting malnutrition at any age has long-term detrimental effects on endocrine and exocrine pancreatic structure and function. Methods: The SAMPA international research programme will assess pancreatic structure and function in 3700 participants from ongoing observational nutrition cohorts, two adolescent and four adult, in Zambia, Tanzania, Philippines, and India. Pancreas size, structure, and calcification will be assessed by ultrasound and computed tomography (CT) scan; exocrine function by faecal elastase and serum lipase; and endocrine function by haemoglobin A1c (HbA1c) and blood glucose, insulin and C-peptide concentrations during an oral glucose tolerance test (OGTT). In-depth hormonal analyses of incretins, glucagon, proinsulin and trypsinogen during OGTT and intravenous glucose tolerance tests will be done in subsets of adult participants. Pancreatic size and function outcomes will be compared between people with and without prior wasting malnutrition. Analyses will investigate effect modification by sex, current age, time since malnutrition, current body mass index and dietary patterns. Mathematical modelling of OGTT data will be used to estimate the relative contribution to glucose dysregulation of decreased insulin production, changes in insulin clearance and increased insulin resistance. Proinsulin/insulin ratio will be analysed in archived samples from the Tanzanian cohort using a nested case-control design to investigate whether abnormal values precede diabetes. Conclusions: SAMPA, a large-scale multi-centre research programme using data from people with or without prior wasting malnutrition to assess several aspects of pancreatic phenotype, will provide coherent evidence for future policies and programmes for malnutrition and diabetes.

AB - Background: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition and NCD aetiology, may not fully recover following malnutrition. However, the evidence and mechanistic information is piecemeal. We hypothesise that wasting malnutrition at any age has long-term detrimental effects on endocrine and exocrine pancreatic structure and function. Methods: The SAMPA international research programme will assess pancreatic structure and function in 3700 participants from ongoing observational nutrition cohorts, two adolescent and four adult, in Zambia, Tanzania, Philippines, and India. Pancreas size, structure, and calcification will be assessed by ultrasound and computed tomography (CT) scan; exocrine function by faecal elastase and serum lipase; and endocrine function by haemoglobin A1c (HbA1c) and blood glucose, insulin and C-peptide concentrations during an oral glucose tolerance test (OGTT). In-depth hormonal analyses of incretins, glucagon, proinsulin and trypsinogen during OGTT and intravenous glucose tolerance tests will be done in subsets of adult participants. Pancreatic size and function outcomes will be compared between people with and without prior wasting malnutrition. Analyses will investigate effect modification by sex, current age, time since malnutrition, current body mass index and dietary patterns. Mathematical modelling of OGTT data will be used to estimate the relative contribution to glucose dysregulation of decreased insulin production, changes in insulin clearance and increased insulin resistance. Proinsulin/insulin ratio will be analysed in archived samples from the Tanzanian cohort using a nested case-control design to investigate whether abnormal values precede diabetes. Conclusions: SAMPA, a large-scale multi-centre research programme using data from people with or without prior wasting malnutrition to assess several aspects of pancreatic phenotype, will provide coherent evidence for future policies and programmes for malnutrition and diabetes.

KW - Faculty of Science

KW - Malnutrition

KW - Wasting

KW - Diabetes

KW - Pancreas

KW - Non-communicable diseases

KW - Oral glucose tolerance test

U2 - 10.12688/f1000research.123389.2

DO - 10.12688/f1000research.123389.2

M3 - Journal article

C2 - 36300035

VL - 11

JO - F1000Research

JF - F1000Research

SN - 2046-1402

M1 - 777

ER -

ID: 324552596