Insulin action in human thighs after one-legged immobilization

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Insulin action in human thighs after one-legged immobilization. / Richter, Erik A.; Kiens, Bente; Mizuno, M.; Strange, Søren.

In: Journal of Applied Physiology, Vol. 67, No. 1, 1989, p. 19-23.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Richter, EA, Kiens, B, Mizuno, M & Strange, S 1989, 'Insulin action in human thighs after one-legged immobilization', Journal of Applied Physiology, vol. 67, no. 1, pp. 19-23.

APA

Richter, E. A., Kiens, B., Mizuno, M., & Strange, S. (1989). Insulin action in human thighs after one-legged immobilization. Journal of Applied Physiology, 67(1), 19-23.

Vancouver

Richter EA, Kiens B, Mizuno M, Strange S. Insulin action in human thighs after one-legged immobilization. Journal of Applied Physiology. 1989;67(1):19-23.

Author

Richter, Erik A. ; Kiens, Bente ; Mizuno, M. ; Strange, Søren. / Insulin action in human thighs after one-legged immobilization. In: Journal of Applied Physiology. 1989 ; Vol. 67, No. 1. pp. 19-23.

Bibtex

@article{a696ee44994a49c68438eda5b283dfdd,
title = "Insulin action in human thighs after one-legged immobilization",
abstract = "Insulin action was assessed in thighs of five healthy young males who had one knee immobilized for 7 days by a splint. The splint was not worn in bed. Subjects also used crutches to prevent weight bearing of the immobilized leg. Immobilization decreased the activity of citrate synthase and 3-OH-acyl-CoA-dehydrogenase in the vastus lateralis muscle by 9 and 14%, respectively, and thigh volume by 5%. After 7 days of immobilization, a two-step euglycemic hyperinsulinemic clamp procedure combined with arterial and bilateral femoral venous catheterization was performed. Insulin action on glucose uptake and tyrosine release of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium. Before and during the clamp step I, lactate release was significantly higher in the immobilized than in the control thigh. Seven days of one-legged immobilization causes local decreased insulin action on thigh glucose uptake and net protein degradation.",
keywords = "Adult, Glucose, Humans, Immobilization, Insulin, Insulin Resistance, Male, Muscle Proteins, Muscles, Thigh",
author = "Richter, {Erik A.} and Bente Kiens and M. Mizuno and S{\o}ren Strange",
year = "1989",
language = "English",
volume = "67",
pages = "19--23",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Insulin action in human thighs after one-legged immobilization

AU - Richter, Erik A.

AU - Kiens, Bente

AU - Mizuno, M.

AU - Strange, Søren

PY - 1989

Y1 - 1989

N2 - Insulin action was assessed in thighs of five healthy young males who had one knee immobilized for 7 days by a splint. The splint was not worn in bed. Subjects also used crutches to prevent weight bearing of the immobilized leg. Immobilization decreased the activity of citrate synthase and 3-OH-acyl-CoA-dehydrogenase in the vastus lateralis muscle by 9 and 14%, respectively, and thigh volume by 5%. After 7 days of immobilization, a two-step euglycemic hyperinsulinemic clamp procedure combined with arterial and bilateral femoral venous catheterization was performed. Insulin action on glucose uptake and tyrosine release of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium. Before and during the clamp step I, lactate release was significantly higher in the immobilized than in the control thigh. Seven days of one-legged immobilization causes local decreased insulin action on thigh glucose uptake and net protein degradation.

AB - Insulin action was assessed in thighs of five healthy young males who had one knee immobilized for 7 days by a splint. The splint was not worn in bed. Subjects also used crutches to prevent weight bearing of the immobilized leg. Immobilization decreased the activity of citrate synthase and 3-OH-acyl-CoA-dehydrogenase in the vastus lateralis muscle by 9 and 14%, respectively, and thigh volume by 5%. After 7 days of immobilization, a two-step euglycemic hyperinsulinemic clamp procedure combined with arterial and bilateral femoral venous catheterization was performed. Insulin action on glucose uptake and tyrosine release of the thighs at mean plasma insulin concentrations of 67 (clamp step I) and 447 microU/ml (clamp step II) was decreased by immobilization, whereas immobilization did not affect insulin action on thigh exchange of free fatty acids, glycerol, O2, or potassium. Before and during the clamp step I, lactate release was significantly higher in the immobilized than in the control thigh. Seven days of one-legged immobilization causes local decreased insulin action on thigh glucose uptake and net protein degradation.

KW - Adult

KW - Glucose

KW - Humans

KW - Immobilization

KW - Insulin

KW - Insulin Resistance

KW - Male

KW - Muscle Proteins

KW - Muscles

KW - Thigh

M3 - Journal article

C2 - 2668254

VL - 67

SP - 19

EP - 23

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

ID: 154756678