Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. / Kjær, Michael; Mikines, K J; Christensen, N J; Tronier, B; Vinten, Jørgen; Sonne, B; Richter, Erik A.; Galbo, H.

In: Journal of Applied Physiology, Vol. 57, No. 1, 1984, p. 21-27.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kjær, M, Mikines, KJ, Christensen, NJ, Tronier, B, Vinten, J, Sonne, B, Richter, EA & Galbo, H 1984, 'Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans', Journal of Applied Physiology, vol. 57, no. 1, pp. 21-27.

APA

Kjær, M., Mikines, K. J., Christensen, N. J., Tronier, B., Vinten, J., Sonne, B., Richter, E. A., & Galbo, H. (1984). Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. Journal of Applied Physiology, 57(1), 21-27.

Vancouver

Kjær M, Mikines KJ, Christensen NJ, Tronier B, Vinten J, Sonne B et al. Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. Journal of Applied Physiology. 1984;57(1):21-27.

Author

Kjær, Michael ; Mikines, K J ; Christensen, N J ; Tronier, B ; Vinten, Jørgen ; Sonne, B ; Richter, Erik A. ; Galbo, H. / Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans. In: Journal of Applied Physiology. 1984 ; Vol. 57, No. 1. pp. 21-27.

Bibtex

@article{736e8e4e27924b0b8495585d775ee735,
title = "Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans",
abstract = "Eight athletes (T), studied the third morning after the last exercise session, and seven sedentary males (C) (maximal O2 consumption 65 +/- 4 vs. 49 +/- 4 (SE) ml X kg-1 X min-1, for T and C men, respectively) had insulin infused until plasma glucose, at an insulin level of 1,600 pmol X l-1, was 1.9 mmol X l-1. Glucose turnover was determined by primed constant rate infusion of 3-[3H]glucose. Basal C-peptide (0.46 +/- 0.04 vs. 0.73 +/- 0.06 pmol X ml-1) and glucagon (4 +/- 0.4 vs. 10 +/- 2 pmol X l-1) were lower (P less than 0.05) and epinephrine higher (0.30 +/- 0.06 vs. 0.09 +/- 0.03 nmol X l-1) in T than in C subjects. During and after insulin infusion production, disappearance and clearance of glucose changed identically in T and C subjects. However, in spite of identical plasma glucose concentrations, epinephrine (7.88 +/- 0.99 vs. 3.97 +/- 0.40 nmol X l-1), growth hormone (97 +/- 17 vs. 64 +/- 6 mU X l-1), and pancreatic polypeptide (361 +/- 84 vs. 180 +/- 29 pmol X l-1) reached higher levels (P less than 0.05) and glucagon (28 +/- 3 vs. 47 +/- 10 pmol X l-1) lower levels in T than in C subjects. Blood pressures changed earlier in athletes during insulin infusion, and early recovery of heart rate, free fatty acid, and glycerol was faster. Responses of norepinephrine, cortisol, C-peptide, and lactate were similar in the two groups. Training radically changes hormonal responses but not glucose kinetics in insulin hypoglycemia.",
keywords = "Adult, Blood Glucose, Blood Pressure, Catecholamines, Fatty Acids, Nonesterified, Growth Hormone, Heart Rate, Hematocrit, Hormones, Humans, Hydrocortisone, Hypoglycemia, Insulin, Male, Pancreatic Hormones, Physical Exertion",
author = "Michael Kj{\ae}r and Mikines, {K J} and Christensen, {N J} and B Tronier and J{\o}rgen Vinten and B Sonne and Richter, {Erik A.} and H Galbo",
year = "1984",
language = "English",
volume = "57",
pages = "21--27",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Glucose turnover and hormonal changes during insulin-induced hypoglycemia in trained humans

AU - Kjær, Michael

AU - Mikines, K J

AU - Christensen, N J

AU - Tronier, B

AU - Vinten, Jørgen

AU - Sonne, B

AU - Richter, Erik A.

AU - Galbo, H

PY - 1984

Y1 - 1984

N2 - Eight athletes (T), studied the third morning after the last exercise session, and seven sedentary males (C) (maximal O2 consumption 65 +/- 4 vs. 49 +/- 4 (SE) ml X kg-1 X min-1, for T and C men, respectively) had insulin infused until plasma glucose, at an insulin level of 1,600 pmol X l-1, was 1.9 mmol X l-1. Glucose turnover was determined by primed constant rate infusion of 3-[3H]glucose. Basal C-peptide (0.46 +/- 0.04 vs. 0.73 +/- 0.06 pmol X ml-1) and glucagon (4 +/- 0.4 vs. 10 +/- 2 pmol X l-1) were lower (P less than 0.05) and epinephrine higher (0.30 +/- 0.06 vs. 0.09 +/- 0.03 nmol X l-1) in T than in C subjects. During and after insulin infusion production, disappearance and clearance of glucose changed identically in T and C subjects. However, in spite of identical plasma glucose concentrations, epinephrine (7.88 +/- 0.99 vs. 3.97 +/- 0.40 nmol X l-1), growth hormone (97 +/- 17 vs. 64 +/- 6 mU X l-1), and pancreatic polypeptide (361 +/- 84 vs. 180 +/- 29 pmol X l-1) reached higher levels (P less than 0.05) and glucagon (28 +/- 3 vs. 47 +/- 10 pmol X l-1) lower levels in T than in C subjects. Blood pressures changed earlier in athletes during insulin infusion, and early recovery of heart rate, free fatty acid, and glycerol was faster. Responses of norepinephrine, cortisol, C-peptide, and lactate were similar in the two groups. Training radically changes hormonal responses but not glucose kinetics in insulin hypoglycemia.

AB - Eight athletes (T), studied the third morning after the last exercise session, and seven sedentary males (C) (maximal O2 consumption 65 +/- 4 vs. 49 +/- 4 (SE) ml X kg-1 X min-1, for T and C men, respectively) had insulin infused until plasma glucose, at an insulin level of 1,600 pmol X l-1, was 1.9 mmol X l-1. Glucose turnover was determined by primed constant rate infusion of 3-[3H]glucose. Basal C-peptide (0.46 +/- 0.04 vs. 0.73 +/- 0.06 pmol X ml-1) and glucagon (4 +/- 0.4 vs. 10 +/- 2 pmol X l-1) were lower (P less than 0.05) and epinephrine higher (0.30 +/- 0.06 vs. 0.09 +/- 0.03 nmol X l-1) in T than in C subjects. During and after insulin infusion production, disappearance and clearance of glucose changed identically in T and C subjects. However, in spite of identical plasma glucose concentrations, epinephrine (7.88 +/- 0.99 vs. 3.97 +/- 0.40 nmol X l-1), growth hormone (97 +/- 17 vs. 64 +/- 6 mU X l-1), and pancreatic polypeptide (361 +/- 84 vs. 180 +/- 29 pmol X l-1) reached higher levels (P less than 0.05) and glucagon (28 +/- 3 vs. 47 +/- 10 pmol X l-1) lower levels in T than in C subjects. Blood pressures changed earlier in athletes during insulin infusion, and early recovery of heart rate, free fatty acid, and glycerol was faster. Responses of norepinephrine, cortisol, C-peptide, and lactate were similar in the two groups. Training radically changes hormonal responses but not glucose kinetics in insulin hypoglycemia.

KW - Adult

KW - Blood Glucose

KW - Blood Pressure

KW - Catecholamines

KW - Fatty Acids, Nonesterified

KW - Growth Hormone

KW - Heart Rate

KW - Hematocrit

KW - Hormones

KW - Humans

KW - Hydrocortisone

KW - Hypoglycemia

KW - Insulin

KW - Male

KW - Pancreatic Hormones

KW - Physical Exertion

M3 - Journal article

C2 - 6381435

VL - 57

SP - 21

EP - 27

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -

ID: 154759578