Exercise increases circulating GDF15 in humans

Research output: Contribution to journalLetterpeer-review

Standard

Exercise increases circulating GDF15 in humans. / Kleinert, Maximilian; Clemmensen, Christoffer; Sjøberg, Kim Anker; Carl, Christian Strini; Jeppesen, Jacob Fuglsbjerg; Wojtaszewski, Jørgen; Kiens, Bente; Richter, Erik A.

In: Molecular Metabolism, Vol. 9, 2018, p. 187-191.

Research output: Contribution to journalLetterpeer-review

Harvard

Kleinert, M, Clemmensen, C, Sjøberg, KA, Carl, CS, Jeppesen, JF, Wojtaszewski, J, Kiens, B & Richter, EA 2018, 'Exercise increases circulating GDF15 in humans', Molecular Metabolism, vol. 9, pp. 187-191. https://doi.org/10.1016/j.molmet.2017.12.016

APA

Kleinert, M., Clemmensen, C., Sjøberg, K. A., Carl, C. S., Jeppesen, J. F., Wojtaszewski, J., Kiens, B., & Richter, E. A. (2018). Exercise increases circulating GDF15 in humans. Molecular Metabolism, 9, 187-191. https://doi.org/10.1016/j.molmet.2017.12.016

Vancouver

Kleinert M, Clemmensen C, Sjøberg KA, Carl CS, Jeppesen JF, Wojtaszewski J et al. Exercise increases circulating GDF15 in humans. Molecular Metabolism. 2018;9:187-191. https://doi.org/10.1016/j.molmet.2017.12.016

Author

Kleinert, Maximilian ; Clemmensen, Christoffer ; Sjøberg, Kim Anker ; Carl, Christian Strini ; Jeppesen, Jacob Fuglsbjerg ; Wojtaszewski, Jørgen ; Kiens, Bente ; Richter, Erik A. / Exercise increases circulating GDF15 in humans. In: Molecular Metabolism. 2018 ; Vol. 9. pp. 187-191.

Bibtex

@article{d24b90995987466082f398150223519a,
title = "Exercise increases circulating GDF15 in humans",
abstract = "Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans.Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples.Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered.Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.",
keywords = "Skeletal muscle, Growth differentiation factor 15, Recovery, Physical activity",
author = "Maximilian Kleinert and Christoffer Clemmensen and Sj{\o}berg, {Kim Anker} and Carl, {Christian Strini} and Jeppesen, {Jacob Fuglsbjerg} and J{\o}rgen Wojtaszewski and Bente Kiens and Richter, {Erik A.}",
note = "CURIS 2018 NEXS 060",
year = "2018",
doi = "10.1016/j.molmet.2017.12.016",
language = "English",
volume = "9",
pages = "187--191",
journal = "Molecular Metabolism",
issn = "2212-8778",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Exercise increases circulating GDF15 in humans

AU - Kleinert, Maximilian

AU - Clemmensen, Christoffer

AU - Sjøberg, Kim Anker

AU - Carl, Christian Strini

AU - Jeppesen, Jacob Fuglsbjerg

AU - Wojtaszewski, Jørgen

AU - Kiens, Bente

AU - Richter, Erik A.

N1 - CURIS 2018 NEXS 060

PY - 2018

Y1 - 2018

N2 - Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans.Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples.Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered.Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.

AB - Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans.Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples.Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered.Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.

KW - Skeletal muscle

KW - Growth differentiation factor 15

KW - Recovery

KW - Physical activity

U2 - 10.1016/j.molmet.2017.12.016

DO - 10.1016/j.molmet.2017.12.016

M3 - Letter

C2 - 29398617

VL - 9

SP - 187

EP - 191

JO - Molecular Metabolism

JF - Molecular Metabolism

SN - 2212-8778

ER -

ID: 189663508