EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle
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EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle. / Jensen, Thomas Elbenhardt; Leutert, Robin; Rasmussen, Søren T; Mouatt, Joshua Roger; Christiansen, Mette Landau Brabæk; Jensen, Bente Rona; Richter, Erik A.
In: P L o S One, Vol. 7, No. 2, 2012, p. e31054.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle
AU - Jensen, Thomas Elbenhardt
AU - Leutert, Robin
AU - Rasmussen, Søren T
AU - Mouatt, Joshua Roger
AU - Christiansen, Mette Landau Brabæk
AU - Jensen, Bente Rona
AU - Richter, Erik A.
N1 - CURIS 2012 5200 069
PY - 2012
Y1 - 2012
N2 - In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
AB - In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
KW - Electromyography
KW - Enzyme Activation
KW - Exercise
KW - Glucose Transporter Type 4
KW - Hexokinase
KW - Humans
KW - Muscle, Skeletal
KW - Phosphorylation
KW - Protein Kinases
KW - Signal Transduction
U2 - 10.1371/journal.pone.0031054
DO - 10.1371/journal.pone.0031054
M3 - Journal article
C2 - 22347426
VL - 7
SP - e31054
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 2
ER -
ID: 38565955