Diminished hormonal responses to exercise in trained rats

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Diminished hormonal responses to exercise in trained rats. / Galbo, H; Richter, Erik A.; Holst, J J; Christensen, N J.

In: Journal of Applied Physiology, Vol. 43, No. 6, 1977, p. 953-958.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Galbo, H, Richter, EA, Holst, JJ & Christensen, NJ 1977, 'Diminished hormonal responses to exercise in trained rats', Journal of Applied Physiology, vol. 43, no. 6, pp. 953-958.

APA

Galbo, H., Richter, E. A., Holst, J. J., & Christensen, N. J. (1977). Diminished hormonal responses to exercise in trained rats. Journal of Applied Physiology, 43(6), 953-958.

Vancouver

Galbo H, Richter EA, Holst JJ, Christensen NJ. Diminished hormonal responses to exercise in trained rats. Journal of Applied Physiology. 1977;43(6):953-958.

Author

Galbo, H ; Richter, Erik A. ; Holst, J J ; Christensen, N J. / Diminished hormonal responses to exercise in trained rats. In: Journal of Applied Physiology. 1977 ; Vol. 43, No. 6. pp. 953-958.

Bibtex

@article{72a042cc79a64ce8984c25a93a578f7e,
title = "Diminished hormonal responses to exercise in trained rats",
abstract = "Male rats (120 g) either were subjected to a 12-wk physical training program (T rats) or were sedentary controls (C rats). Subsequently the rats were killed at rest or after a 45- or 90-min forced swim. At rest, T rats had higher liver and muscle glycogen concentrations but lower plasma insulin. During exercise, blood glucose increased 60% in T rats but decreased 20% in C rats. Plasma glucagon and insulin concentrations did not change in T rats but plasma glucagon increased and insulin decreased markedly in C rats. Plasma epinephrine (90 min: range, 0.78-2.96 ng-ml-1, (T) vs. 4.42-15.67 (C)) and norepinephrine (90 min: 0.70-2.22 (T) vs. 2.50-6.10 (C)) were lower in T than in C rats. Hepatic glycogen decreased substantially and, as with muscle glycogen, the decrease was parallel in T and C rats. The plasma concentrations of free fatty acids were higher but lactate and alanine lower in T than in C rats. In trained rats the hormonal response to exercise is blunted partly due to higher glucose concentrations. In these rats adipose tissue sensitivity to catecholamines is increased, and changes in glucagon and insulin concentrations are not necessary for increased lipolysis and hepatic glycogen depletion during exercise.",
keywords = "Animals, Blood Glucose, Catecholamines, Glucagon, Glycogen, Insulin, Lipid Mobilization, Liver Glycogen, Male, Muscles, Physical Conditioning, Animal, Physical Exertion, Rats",
author = "H Galbo and Richter, {Erik A.} and Holst, {J J} and Christensen, {N J}",
year = "1977",
language = "English",
volume = "43",
pages = "953--958",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Diminished hormonal responses to exercise in trained rats

AU - Galbo, H

AU - Richter, Erik A.

AU - Holst, J J

AU - Christensen, N J

PY - 1977

Y1 - 1977

N2 - Male rats (120 g) either were subjected to a 12-wk physical training program (T rats) or were sedentary controls (C rats). Subsequently the rats were killed at rest or after a 45- or 90-min forced swim. At rest, T rats had higher liver and muscle glycogen concentrations but lower plasma insulin. During exercise, blood glucose increased 60% in T rats but decreased 20% in C rats. Plasma glucagon and insulin concentrations did not change in T rats but plasma glucagon increased and insulin decreased markedly in C rats. Plasma epinephrine (90 min: range, 0.78-2.96 ng-ml-1, (T) vs. 4.42-15.67 (C)) and norepinephrine (90 min: 0.70-2.22 (T) vs. 2.50-6.10 (C)) were lower in T than in C rats. Hepatic glycogen decreased substantially and, as with muscle glycogen, the decrease was parallel in T and C rats. The plasma concentrations of free fatty acids were higher but lactate and alanine lower in T than in C rats. In trained rats the hormonal response to exercise is blunted partly due to higher glucose concentrations. In these rats adipose tissue sensitivity to catecholamines is increased, and changes in glucagon and insulin concentrations are not necessary for increased lipolysis and hepatic glycogen depletion during exercise.

AB - Male rats (120 g) either were subjected to a 12-wk physical training program (T rats) or were sedentary controls (C rats). Subsequently the rats were killed at rest or after a 45- or 90-min forced swim. At rest, T rats had higher liver and muscle glycogen concentrations but lower plasma insulin. During exercise, blood glucose increased 60% in T rats but decreased 20% in C rats. Plasma glucagon and insulin concentrations did not change in T rats but plasma glucagon increased and insulin decreased markedly in C rats. Plasma epinephrine (90 min: range, 0.78-2.96 ng-ml-1, (T) vs. 4.42-15.67 (C)) and norepinephrine (90 min: 0.70-2.22 (T) vs. 2.50-6.10 (C)) were lower in T than in C rats. Hepatic glycogen decreased substantially and, as with muscle glycogen, the decrease was parallel in T and C rats. The plasma concentrations of free fatty acids were higher but lactate and alanine lower in T than in C rats. In trained rats the hormonal response to exercise is blunted partly due to higher glucose concentrations. In these rats adipose tissue sensitivity to catecholamines is increased, and changes in glucagon and insulin concentrations are not necessary for increased lipolysis and hepatic glycogen depletion during exercise.

KW - Animals

KW - Blood Glucose

KW - Catecholamines

KW - Glucagon

KW - Glycogen

KW - Insulin

KW - Lipid Mobilization

KW - Liver Glycogen

KW - Male

KW - Muscles

KW - Physical Conditioning, Animal

KW - Physical Exertion

KW - Rats

M3 - Journal article

C2 - 606699

VL - 43

SP - 953

EP - 958

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -

ID: 154761148