Diet-induced Arrangement of the gut Microbiome for Improvement of Cardiometabolic health
The project will generate more knowledge on the interplay between diet and gut microbiome with the purpose of preventing cardiovascular diseases in humans.
The gut microbiota, i.e. the communities of microorganisms in the human intestine, was recently recognized as an important factor influencing health throughout all stages of life. Obesity and type-2 diabetes have globally reached pandemic-like prevalence and are major risk factors for the development of cardiovascular diseases, in particular coronary artery disease and stroke.
These pathologies are referred to as cardiometabolic diseases (CMD), and to effectively tackle them it is crucial to understand interplays between dietary and microbial factors that promote or inhibit transition from early metabolic symptoms to cardiovascular complications. CMD are associated with alterations in the composition and function of the microbiota.
The DINAMIC consortium will investigate interactions between diet and the gut microbiota, and the potential of modulating these interactions for prevention of metabolic dysfunction and cardiovascular complications in humans.
|Jean-François Brugère||Université Clermont Auvergne|
|Thomas Clavel||University Hospital of RWTH Aachen|
|Danilo Ercolini||University of Naples Federico II|
|Dirk Haller||Technical University of Munich|
|Max Nieuwdorp||Amsterdam University Medical Center|
|Paul O’Toole||University College Cork|
|Annette Peters||Helmholtz Center Munich|
|Tim Spector||Kings College London|