DNA adductomics for Research in Colorectal Cancer
The DNA adductomics project will give new insights into the causes of DNA damage in colorectal cancer, leading to the development of new preventive and therapeutic approaches.
Colorectal cancer (CRC) develops as a result of multiple genetic damage, including the chemical interaction of toxic molecules with DNA, forming DNA adducts.
These toxic compounds may come from exogenous sources such as environment, diet and gut microbiota or from our endogenous metabolic processes such as inflammation.
- The first purpose of the project is to identify DNA adducts related to CRC in colon tissues from patients with CRC vs controls, by using a UHPLC-HRMS based untargeted DNA adductomics.
This will possibly lead to the understanding of the causes of DNA damage and to develop new therapeutical approaches towards CRC. - The second purpose of the project is to identify DNA adducts in urine, blood or faecal samples from the same patients, to understand whether the systemic levels reflect the local DNA adduct levels.
This will allow to perform future studies by a less invasive sample collection and therefore to develop new diagnostic and preventive approaches.
Involved in the project
Internal
| Name | Title | Phone | |
|---|---|---|---|
| Lars Ove Dragsted | Head of Section | +4535332694 |
Students
| Name | Title | Institution |
|---|---|---|
| Amalie M Sola-Gross Kristensen | Student | amalie@nexs.ku.dk |
| Cilia Boest Nielsen | Student | tcv415@alumni.ku.dk |
| Katrine Dalmo Sommesen | Student | sdz828@alumni.ku.dk |
| Sara Lorenzi | Student | 20036602@studenti.uniupo.it |
External
| Name | Title | Institution |
|---|---|---|
| Lars Joachim Lindberg | Professor | Gastrounit, Hvidovre Hospital |
| John Gasdal Karstensen | Professor | Gastrounit, Hvidovre Hospital |
| Søren Hammershøj Beck | Student | Gastrounit, Hvidovre Hospital |
Contact
Giorgia La Barbera, glb@nexs.ku.dk