DNA adductomics for Research in Colorectal Cancer

The DNA adductomics project will give new insights into the causes of DNA damage in colorectal cancer, leading to the development of new preventive and therapeutic approaches.

Colorectal cancer (CRC) develops as a result of multiple genetic damage, including the chemical interaction of toxic molecules with DNA, forming DNA adducts.

These toxic compounds may come from exogenous sources such as environment, diet and gut microbiota or from our endogenous metabolic processes such as inflammation.

 

  • The first purpose of the project is to identify DNA adducts related to CRC in colon tissues from patients with CRC vs controls, by using a UHPLC-HRMS based untargeted DNA adductomics.
    This will possibly lead to the understanding of the causes of DNA damage and to develop new therapeutical approaches towards CRC.
  • The second purpose of the project is to identify DNA adducts in urine, blood or faecal samples from the same patients, to understand whether the systemic levels reflect the local DNA adduct levels.
    This will allow to perform future studies by a less invasive sample collection and therefore to develop new diagnostic and preventive approaches.

 

 

 

 

Involved in the project

Internal

Name Title Phone E-mail
Lars Ove Dragsted Head of Section +4535332694 E-mail

Students

Name Title Institution
Amalie M Sola-Gross Kristensen Student  amalie@nexs.ku.dk
Cilia Boest Nielsen Student tcv415@alumni.ku.dk
Katrine Dalmo Sommesen Student sdz828@alumni.ku.dk
Sara Lorenzi Student 20036602@studenti.uniupo.it

External

Name Title Institution
Lars Joachim Lindberg Professor  Gastrounit, Hvidovre Hospital
John Gasdal Karstensen Professor Gastrounit, Hvidovre Hospital
Søren Hammershøj Beck Student Gastrounit, Hvidovre Hospital

Funded by

Marie-Curie Individual Fellowship (Horizon H2020-EU)

Period:  May 2019 – September 2021

Contact

Giorgia La Barbera, glb@nexs.ku.dk