Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

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Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. / Roumans, Nadia J T; Vink, Roel G; Gielen, Marij; Zeegers, Maurice P; Holst, Claus; Wang, Ping; Astrup, Arne; Saris, Wim H; Valsesia, Armand; Hager, Jörg; van Baak, Marleen A; Mariman, Edwin C M.

In: Genes & Nutrition, Vol. 10, No. 6, 56, 2015.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Roumans, NJT, Vink, RG, Gielen, M, Zeegers, MP, Holst, C, Wang, P, Astrup, A, Saris, WH, Valsesia, A, Hager, J, van Baak, MA & Mariman, ECM 2015, 'Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner', Genes & Nutrition, vol. 10, no. 6, 56. https://doi.org/10.1007/s12263-015-0506-y

APA

Roumans, N. J. T., Vink, R. G., Gielen, M., Zeegers, M. P., Holst, C., Wang, P., Astrup, A., Saris, W. H., Valsesia, A., Hager, J., van Baak, M. A., & Mariman, E. C. M. (2015). Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. Genes & Nutrition, 10(6), [56]. https://doi.org/10.1007/s12263-015-0506-y

Vancouver

Roumans NJT, Vink RG, Gielen M, Zeegers MP, Holst C, Wang P et al. Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. Genes & Nutrition. 2015;10(6). 56. https://doi.org/10.1007/s12263-015-0506-y

Author

Roumans, Nadia J T ; Vink, Roel G ; Gielen, Marij ; Zeegers, Maurice P ; Holst, Claus ; Wang, Ping ; Astrup, Arne ; Saris, Wim H ; Valsesia, Armand ; Hager, Jörg ; van Baak, Marleen A ; Mariman, Edwin C M. / Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner. In: Genes & Nutrition. 2015 ; Vol. 10, No. 6.

Bibtex

@article{c1093411e8b2442f81e11b21c76abe57,
title = "Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner",
abstract = "The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 % CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 % CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 % CI 2.35-144.63) and in a recessive model (OR 16.36, 95 % CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 % CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 % CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 % CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 % CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.",
author = "Roumans, {Nadia J T} and Vink, {Roel G} and Marij Gielen and Zeegers, {Maurice P} and Claus Holst and Ping Wang and Arne Astrup and Saris, {Wim H} and Armand Valsesia and J{\"o}rg Hager and {van Baak}, {Marleen A} and Mariman, {Edwin C M}",
note = "CURIS 2015 NEXS 342",
year = "2015",
doi = "10.1007/s12263-015-0506-y",
language = "English",
volume = "10",
journal = "Genes & Nutrition",
issn = "1555-8932",
publisher = "BioMed Central Ltd.",
number = "6",

}

RIS

TY - JOUR

T1 - Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

AU - Roumans, Nadia J T

AU - Vink, Roel G

AU - Gielen, Marij

AU - Zeegers, Maurice P

AU - Holst, Claus

AU - Wang, Ping

AU - Astrup, Arne

AU - Saris, Wim H

AU - Valsesia, Armand

AU - Hager, Jörg

AU - van Baak, Marleen A

AU - Mariman, Edwin C M

N1 - CURIS 2015 NEXS 342

PY - 2015

Y1 - 2015

N2 - The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 % CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 % CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 % CI 2.35-144.63) and in a recessive model (OR 16.36, 95 % CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 % CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 % CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 % CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 % CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.

AB - The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of the European DiOGenes study. Overweight and obese subjects (n = 469, 310 females, 159 males) were on an 8-week low-calorie diet with a 6-month follow-up. Body weight was measured before and after the diet, and after follow-up. Weight maintenance scores (WMS, regained weight as percentage of lost weight) were calculated based on the weight data. Genotype data were retrieved for 2903 SNPs corresponding to 124 ECM-related genes. Regression analyses provided us with six significant SNPs associated with the WMS in males: 3 SNPs in the POSTN gene and a SNP in the LAMB1, COL23A1, and FBLN5 genes. For females, 1 SNP was found in the FN1 gene. The risk of weight regain was increased by: the C/C genotype for POSTN in a co-dominant model (OR 8.25, 95 % CI 2.85-23.88) and the T/C-C/C genotype in a dominant model (OR 4.88, 95 % CI 2.35-10.16); the A/A genotype for LAMB1 both in a co-dominant model (OR 18.43, 95 % CI 2.35-144.63) and in a recessive model (OR 16.36, 95 % CI 2.14-124.9); the G/A genotype for COL23A1 in a co-dominant model (OR 3.94, 95 % CI 1.28-12.10), or the A-allele in a dominant model (OR 2.86, 95 % CI 1.10-7.49); the A/A genotype for FBLN5 in a co-dominant model (OR 13.00, 95 % CI 1.61-104.81); and the A/A genotype for FN1 in a recessive model (OR 2.81, 95 % CI 1.40-5.63). Concluding, variants of ECM genes are associated with weight regain after weight loss in a sex-specific manner.

U2 - 10.1007/s12263-015-0506-y

DO - 10.1007/s12263-015-0506-y

M3 - Journal article

C2 - 26584808

VL - 10

JO - Genes & Nutrition

JF - Genes & Nutrition

SN - 1555-8932

IS - 6

M1 - 56

ER -

ID: 156372113