Pretreatment fasting plasma glucose modifies dietary weight loss maintenance success: Results from a stratified RCT

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OBJECTIVE: Levels of fasting plasma glucose (FPG) and fasting insulin (FI) were studied as diet-specific prognostic markers for successful weight loss maintenance in participants with overweight.

METHODS: After losing ≥ 8% of body weight, participants received one of three ad libitum diets for 6 months: (1) a moderate-fat diet high in monounsaturated fatty acids (MUFA); (2) a low-fat, high-fiber diet (Nordic Nutrition Recommendations [NNR]); and (3) the Average Danish Diet (ADD). Participants were categorized as having low (< 90 (90-105 (fi ≤ 50 a among as based cutoff dl) fi fi  for fpg having high l; median mg on or pmol preintervention those used values. was> 50 pmol/L).

RESULTS: Participants with low FPG and randomized to MUFA, NNR, and ADD regained similarly 2.1 to 2.5 kg after 6 months. By contrast, participants with high FPG and randomized to MUFA, NNR, and ADD regained 2.73 kg (95% CI 1.33 to 4.13; P < 0.001), -0.05 kg (95% CI -1.95 to 1.86; P = 0.96), and 4.16 kg (95% CI 2.27 to 6.06; P < 0.001) after 6 months, respectively, resulting in lower weight regain on NNR compared to ADD (-4.21 kg [95% CI -6.83 to -1.59]; P = 0.002) and MUFA (95% CI -2.77 kg [-5.12 to -0.43]; P = 0.020). The addition of FI strengthened these associations.

CONCLUSIONS: Slightly elevated pretreatment FPG determined success in dietary weight loss maintenance among overweight patients on ad libitum diets differing in macronutrient and fiber content.

Original languageEnglish
JournalObesity
Volume25
Issue number12
Pages (from-to)2045-2048
Number of pages4
ISSN1930-7381
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article

ID: 184390367