Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study

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Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study. / Hjorth, Mads Fiil; Bray, George A; Zohar, Yishai; Urban, Lorien; Miketinas, Derek C; Williamson, Donald A; Ryan, Donna H; Rood, Jennifer; Champagne, Catherine M; Sacks, Frank M; Astrup, Arne.

In: Nutrients, Vol. 11, No. 3, 586, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Hjorth, MF, Bray, GA, Zohar, Y, Urban, L, Miketinas, DC, Williamson, DA, Ryan, DH, Rood, J, Champagne, CM, Sacks, FM & Astrup, A 2019, 'Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study', Nutrients, vol. 11, no. 3, 586. https://doi.org/10.3390/nu11030586

APA

Hjorth, M. F., Bray, G. A., Zohar, Y., Urban, L., Miketinas, D. C., Williamson, D. A., ... Astrup, A. (2019). Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study. Nutrients, 11(3), [586]. https://doi.org/10.3390/nu11030586

Vancouver

Hjorth MF, Bray GA, Zohar Y, Urban L, Miketinas DC, Williamson DA et al. Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study. Nutrients. 2019;11(3). 586. https://doi.org/10.3390/nu11030586

Author

Hjorth, Mads Fiil ; Bray, George A ; Zohar, Yishai ; Urban, Lorien ; Miketinas, Derek C ; Williamson, Donald A ; Ryan, Donna H ; Rood, Jennifer ; Champagne, Catherine M ; Sacks, Frank M ; Astrup, Arne. / Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study. In: Nutrients. 2019 ; Vol. 11, No. 3.

Bibtex

@article{891b466ac21446e38f53f4278b3a0276,
title = "Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study",
abstract = "Efforts to identify a preferable diet for weight management based on macronutrient composition have largely failed, but recent evidence suggests that satiety effects of carbohydrates may depend on the individual's insulin-mediated cellular glucose uptake. Therefore, using data from the POUNDS LOST trial, pre-treatment fasting plasma glucose (FPG), fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as prognostic markers of long-term weight loss in four diets differing in carbohydrate, fat, and protein content, while assessing the role of dietary fiber intake. Subjects with FPG <100 mg/dL lost 2.6 (95{\%} CI 0.9;4.4, p = 0.003) kg more on the low-fat/high-protein (n = 132) compared to the low-fat/average-protein diet (n = 136). Subjects with HOMA-IR ≥4 lost 3.6 (95{\%} CI 0.2;7.1, p = 0.038) kg more body weight on the high-fat/high-protein (n = 35) compared to high-fat/average-protein diet (n = 33). Regardless of the randomized diet, subjects with prediabetes and FI below the median lost 5.6 kg (95{\%} CI 0.6;10.6, p = 0.030) more when consuming ≥35 g (n = 15) compared to <35 g dietary fiber/10 MJ (n = 16). Overall, subjects with normal glycemia lost most on the low-fat/high-protein diet, subjects with high HOMA-IR lost most on the high-fat/high protein diet, and subjects with prediabetes and low FI had particular benefit from dietary fiber in the diet.",
keywords = "Faculty of Science, Glucose, Insulin, Weight, Diet, Macronutrient composition, Clinical nutrition",
author = "Hjorth, {Mads Fiil} and Bray, {George A} and Yishai Zohar and Lorien Urban and Miketinas, {Derek C} and Williamson, {Donald A} and Ryan, {Donna H} and Jennifer Rood and Champagne, {Catherine M} and Sacks, {Frank M} and Arne Astrup",
note = "CURIS 2019 NEXS 093",
year = "2019",
doi = "10.3390/nu11030586",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - Pretreatment fasting glucose and insulin as determinants of weight loss on diets varying in macronutrients and dietary fibers - The POUNDS LOST Study

AU - Hjorth, Mads Fiil

AU - Bray, George A

AU - Zohar, Yishai

AU - Urban, Lorien

AU - Miketinas, Derek C

AU - Williamson, Donald A

AU - Ryan, Donna H

AU - Rood, Jennifer

AU - Champagne, Catherine M

AU - Sacks, Frank M

AU - Astrup, Arne

N1 - CURIS 2019 NEXS 093

PY - 2019

Y1 - 2019

N2 - Efforts to identify a preferable diet for weight management based on macronutrient composition have largely failed, but recent evidence suggests that satiety effects of carbohydrates may depend on the individual's insulin-mediated cellular glucose uptake. Therefore, using data from the POUNDS LOST trial, pre-treatment fasting plasma glucose (FPG), fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as prognostic markers of long-term weight loss in four diets differing in carbohydrate, fat, and protein content, while assessing the role of dietary fiber intake. Subjects with FPG <100 mg/dL lost 2.6 (95% CI 0.9;4.4, p = 0.003) kg more on the low-fat/high-protein (n = 132) compared to the low-fat/average-protein diet (n = 136). Subjects with HOMA-IR ≥4 lost 3.6 (95% CI 0.2;7.1, p = 0.038) kg more body weight on the high-fat/high-protein (n = 35) compared to high-fat/average-protein diet (n = 33). Regardless of the randomized diet, subjects with prediabetes and FI below the median lost 5.6 kg (95% CI 0.6;10.6, p = 0.030) more when consuming ≥35 g (n = 15) compared to <35 g dietary fiber/10 MJ (n = 16). Overall, subjects with normal glycemia lost most on the low-fat/high-protein diet, subjects with high HOMA-IR lost most on the high-fat/high protein diet, and subjects with prediabetes and low FI had particular benefit from dietary fiber in the diet.

AB - Efforts to identify a preferable diet for weight management based on macronutrient composition have largely failed, but recent evidence suggests that satiety effects of carbohydrates may depend on the individual's insulin-mediated cellular glucose uptake. Therefore, using data from the POUNDS LOST trial, pre-treatment fasting plasma glucose (FPG), fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as prognostic markers of long-term weight loss in four diets differing in carbohydrate, fat, and protein content, while assessing the role of dietary fiber intake. Subjects with FPG <100 mg/dL lost 2.6 (95% CI 0.9;4.4, p = 0.003) kg more on the low-fat/high-protein (n = 132) compared to the low-fat/average-protein diet (n = 136). Subjects with HOMA-IR ≥4 lost 3.6 (95% CI 0.2;7.1, p = 0.038) kg more body weight on the high-fat/high-protein (n = 35) compared to high-fat/average-protein diet (n = 33). Regardless of the randomized diet, subjects with prediabetes and FI below the median lost 5.6 kg (95% CI 0.6;10.6, p = 0.030) more when consuming ≥35 g (n = 15) compared to <35 g dietary fiber/10 MJ (n = 16). Overall, subjects with normal glycemia lost most on the low-fat/high-protein diet, subjects with high HOMA-IR lost most on the high-fat/high protein diet, and subjects with prediabetes and low FI had particular benefit from dietary fiber in the diet.

KW - Faculty of Science

KW - Glucose

KW - Insulin

KW - Weight

KW - Diet

KW - Macronutrient composition

KW - Clinical nutrition

U2 - 10.3390/nu11030586

DO - 10.3390/nu11030586

M3 - Journal article

C2 - 30861997

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

M1 - 586

ER -

ID: 214867950