Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women. / Aarestrup, Julie; Kyrø, Cecilie; Knudsen, Knud Erik Bach; Weiderpass, Elisabete; Christensen, Jane; Kristensen, Mette Bredal; Würtz, Anne Mette Lund; Johnsen, Nina F; Overvad, Kim; Tjønneland, Anne; Olsen, Anja.

In: British Journal of Nutrition, Vol. 109, No. 12, 2013, p. 2269-2275.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Aarestrup, J, Kyrø, C, Knudsen, KEB, Weiderpass, E, Christensen, J, Kristensen, MB, Würtz, AML, Johnsen, NF, Overvad, K, Tjønneland, A & Olsen, A 2013, 'Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women', British Journal of Nutrition, vol. 109, no. 12, pp. 2269-2275. https://doi.org/10.1017/S0007114512004424

APA

Aarestrup, J., Kyrø, C., Knudsen, K. E. B., Weiderpass, E., Christensen, J., Kristensen, M. B., ... Olsen, A. (2013). Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women. British Journal of Nutrition, 109(12), 2269-2275. https://doi.org/10.1017/S0007114512004424

Vancouver

Aarestrup J, Kyrø C, Knudsen KEB, Weiderpass E, Christensen J, Kristensen MB et al. Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women. British Journal of Nutrition. 2013;109(12):2269-2275. https://doi.org/10.1017/S0007114512004424

Author

Aarestrup, Julie ; Kyrø, Cecilie ; Knudsen, Knud Erik Bach ; Weiderpass, Elisabete ; Christensen, Jane ; Kristensen, Mette Bredal ; Würtz, Anne Mette Lund ; Johnsen, Nina F ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja. / Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women. In: British Journal of Nutrition. 2013 ; Vol. 109, No. 12. pp. 2269-2275.

Bibtex

@article{31b25e8f63a741c7bc21d883dbe89270,
title = "Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women",
abstract = "The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case-cohort study in the 'Diet, Cancer and Health' cohort. The cohort study included 29 875 women aged 50-64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 {\%} CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 {\%} CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 {\%} CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.",
author = "Julie Aarestrup and Cecilie Kyr{\o} and Knudsen, {Knud Erik Bach} and Elisabete Weiderpass and Jane Christensen and Kristensen, {Mette Bredal} and W{\"u}rtz, {Anne Mette Lund} and Johnsen, {Nina F} and Kim Overvad and Anne Tj{\o}nneland and Anja Olsen",
note = "CURIS 2013 NEXS 119",
year = "2013",
doi = "10.1017/S0007114512004424",
language = "English",
volume = "109",
pages = "2269--2275",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Plasma enterolactone and incidence of endometrial cancer in a case-cohort study of Danish women

AU - Aarestrup, Julie

AU - Kyrø, Cecilie

AU - Knudsen, Knud Erik Bach

AU - Weiderpass, Elisabete

AU - Christensen, Jane

AU - Kristensen, Mette Bredal

AU - Würtz, Anne Mette Lund

AU - Johnsen, Nina F

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Olsen, Anja

N1 - CURIS 2013 NEXS 119

PY - 2013

Y1 - 2013

N2 - The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case-cohort study in the 'Diet, Cancer and Health' cohort. The cohort study included 29 875 women aged 50-64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.

AB - The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case-cohort study in the 'Diet, Cancer and Health' cohort. The cohort study included 29 875 women aged 50-64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.

U2 - 10.1017/S0007114512004424

DO - 10.1017/S0007114512004424

M3 - Journal article

C2 - 23114205

VL - 109

SP - 2269

EP - 2275

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 12

ER -

ID: 45615137