Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention. / Bolton, Jennifer L; Montastier, Emilie; Carayol, Jérôme; Bonnel, Sophie; Mir, Lucile; Marques, Marie-Adeline; Astrup, Arne; Saris, Wim H.; Iacovoni, Jason S; Villa-Vialaneix, Nathalie; Valsesia, Armand; Langin, Dominique; Viguerie, Nathalie.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 102, No. 8, 2017, p. 2751-2761.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bolton, JL, Montastier, E, Carayol, J, Bonnel, S, Mir, L, Marques, M-A, Astrup, A, Saris, WH, Iacovoni, JS, Villa-Vialaneix, N, Valsesia, A, Langin, D & Viguerie, N 2017, 'Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 8, pp. 2751-2761. https://doi.org/10.1210/jc.2016-3997

APA

Bolton, J. L., Montastier, E., Carayol, J., Bonnel, S., Mir, L., Marques, M-A., Astrup, A., Saris, W. H., Iacovoni, J. S., Villa-Vialaneix, N., Valsesia, A., Langin, D., & Viguerie, N. (2017). Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention. Journal of Clinical Endocrinology and Metabolism, 102(8), 2751-2761. https://doi.org/10.1210/jc.2016-3997

Vancouver

Bolton JL, Montastier E, Carayol J, Bonnel S, Mir L, Marques M-A et al. Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention. Journal of Clinical Endocrinology and Metabolism. 2017;102(8):2751-2761. https://doi.org/10.1210/jc.2016-3997

Author

Bolton, Jennifer L ; Montastier, Emilie ; Carayol, Jérôme ; Bonnel, Sophie ; Mir, Lucile ; Marques, Marie-Adeline ; Astrup, Arne ; Saris, Wim H. ; Iacovoni, Jason S ; Villa-Vialaneix, Nathalie ; Valsesia, Armand ; Langin, Dominique ; Viguerie, Nathalie. / Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention. In: Journal of Clinical Endocrinology and Metabolism. 2017 ; Vol. 102, No. 8. pp. 2751-2761.

Bibtex

@article{2fa16bbb4f4f49e1bfb67e5b30ad6145,
title = "Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention",
abstract = "Context: While calorie restriction has proven beneficial for weight loss, long-term weight control is variable between individuals.Objective: To identify biomarkers of successful weight control during a dietary intervention (DI).Design, Setting, and Participants: Adipose tissue (AT) transcriptomes were compared between 21 obese individuals that either maintained weight loss or regained weight during the DI. Results were validated on 310 individuals from the same study using RT-qPCR, and protein levels of potential circulating biomarkers measured by ELISA.Intervention: Individuals underwent 8-weeks of low-calorie diet, then 6-months of ad libitum diet.Outcome Measure: Weight changes at the end of DI.Results: We evaluated 6 genes that had altered expression during DI, encode secreted proteins, and have not previously been implicated in weight control (EGFL6, FSTL3, CRYAB, TNMD, SPARC, IGFBP3); as well as genes for which baseline expression was different between those with good and poor weight control (ASPN, USP53). Changes in plasma concentration of EGFL6, FSTL3 and CRYAB mirrored AT mRNA expression, all decreased during DI in individuals with good weight control. ASPN and USP53 had higher baseline expression in individuals that went on to have good weight control. eQTL analysis found polymorphisms associated with expression levels of USP53 in AT. A regulatory network was identified in which TGFβ1 was responsible for down-regulation of certain genes during DI in good-controllers. Interestingly, ASPN is a TGFβ1 inhibitor.Conclusions: We found circulating biomarkers associated with weight control, which could influence weight management strategies, and genes that may be prognostic for successful weight control.",
keywords = "Journal Article",
author = "Bolton, {Jennifer L} and Emilie Montastier and J{\'e}r{\^o}me Carayol and Sophie Bonnel and Lucile Mir and Marie-Adeline Marques and Arne Astrup and Saris, {Wim H.} and Iacovoni, {Jason S} and Nathalie Villa-Vialaneix and Armand Valsesia and Dominique Langin and Nathalie Viguerie",
note = "CURIS 2017 NEXS 190",
year = "2017",
doi = "10.1210/jc.2016-3997",
language = "English",
volume = "102",
pages = "2751--2761",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Molecular biomarkers for weight control in obese individuals subjected to a multi-phase dietary intervention

AU - Bolton, Jennifer L

AU - Montastier, Emilie

AU - Carayol, Jérôme

AU - Bonnel, Sophie

AU - Mir, Lucile

AU - Marques, Marie-Adeline

AU - Astrup, Arne

AU - Saris, Wim H.

AU - Iacovoni, Jason S

AU - Villa-Vialaneix, Nathalie

AU - Valsesia, Armand

AU - Langin, Dominique

AU - Viguerie, Nathalie

N1 - CURIS 2017 NEXS 190

PY - 2017

Y1 - 2017

N2 - Context: While calorie restriction has proven beneficial for weight loss, long-term weight control is variable between individuals.Objective: To identify biomarkers of successful weight control during a dietary intervention (DI).Design, Setting, and Participants: Adipose tissue (AT) transcriptomes were compared between 21 obese individuals that either maintained weight loss or regained weight during the DI. Results were validated on 310 individuals from the same study using RT-qPCR, and protein levels of potential circulating biomarkers measured by ELISA.Intervention: Individuals underwent 8-weeks of low-calorie diet, then 6-months of ad libitum diet.Outcome Measure: Weight changes at the end of DI.Results: We evaluated 6 genes that had altered expression during DI, encode secreted proteins, and have not previously been implicated in weight control (EGFL6, FSTL3, CRYAB, TNMD, SPARC, IGFBP3); as well as genes for which baseline expression was different between those with good and poor weight control (ASPN, USP53). Changes in plasma concentration of EGFL6, FSTL3 and CRYAB mirrored AT mRNA expression, all decreased during DI in individuals with good weight control. ASPN and USP53 had higher baseline expression in individuals that went on to have good weight control. eQTL analysis found polymorphisms associated with expression levels of USP53 in AT. A regulatory network was identified in which TGFβ1 was responsible for down-regulation of certain genes during DI in good-controllers. Interestingly, ASPN is a TGFβ1 inhibitor.Conclusions: We found circulating biomarkers associated with weight control, which could influence weight management strategies, and genes that may be prognostic for successful weight control.

AB - Context: While calorie restriction has proven beneficial for weight loss, long-term weight control is variable between individuals.Objective: To identify biomarkers of successful weight control during a dietary intervention (DI).Design, Setting, and Participants: Adipose tissue (AT) transcriptomes were compared between 21 obese individuals that either maintained weight loss or regained weight during the DI. Results were validated on 310 individuals from the same study using RT-qPCR, and protein levels of potential circulating biomarkers measured by ELISA.Intervention: Individuals underwent 8-weeks of low-calorie diet, then 6-months of ad libitum diet.Outcome Measure: Weight changes at the end of DI.Results: We evaluated 6 genes that had altered expression during DI, encode secreted proteins, and have not previously been implicated in weight control (EGFL6, FSTL3, CRYAB, TNMD, SPARC, IGFBP3); as well as genes for which baseline expression was different between those with good and poor weight control (ASPN, USP53). Changes in plasma concentration of EGFL6, FSTL3 and CRYAB mirrored AT mRNA expression, all decreased during DI in individuals with good weight control. ASPN and USP53 had higher baseline expression in individuals that went on to have good weight control. eQTL analysis found polymorphisms associated with expression levels of USP53 in AT. A regulatory network was identified in which TGFβ1 was responsible for down-regulation of certain genes during DI in good-controllers. Interestingly, ASPN is a TGFβ1 inhibitor.Conclusions: We found circulating biomarkers associated with weight control, which could influence weight management strategies, and genes that may be prognostic for successful weight control.

KW - Journal Article

U2 - 10.1210/jc.2016-3997

DO - 10.1210/jc.2016-3997

M3 - Journal article

C2 - 28482007

VL - 102

SP - 2751

EP - 2761

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -

ID: 177383683