Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes
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Metformin has been reported to reduce a-dicarbonyls, which are known to contribute to diabetic complications. It is unclear whether this is due to direct quenching of a-dicarbonyls or to an improvement in glycemic control. We therefore compared the effects of metformin versus repaglinide, an antihyperglycemic agent with an insulin-secreting mechanism, on the levels of the a-dicarbonyl 3-deoxyglucosone (3DG).
|Journal||European Journal of Endocrinology|
|Number of pages||9|
|Publication status||Published - 2011|
- Carbamates, Confidence Intervals, Deoxyglucose, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Metformin, Piperidines