Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study

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Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study. / Myhrstad, Mari C W; de Mello, Vanessa D; Dahlman, Ingrid; Kolehmainen, Marjukka; Paananen, Jussi; Rundblad, Amanda; Carlberg, Carsten; Olstad, Ole Kristoffer; Pihlajamäki, Jussi; Holven, Kirsten B; Hermansen, Kjeld; Dragsted, Lars Ove; Gunnarsdottir, Ingibjörg; Cloetens, Lieselotte; Storm, Matilda Ulmius; Åkesson, Björn; Rosqvist, Fredrik; Hukkanen, Janne; Herzig, Karl-Heinz; Risérus, Ulf; Thorsdottir, Inga; Poutanen, Kaisa S; Savolainen, Markku J; Schwab, Ursula; Arner, Peter; Uusitupa, Matti; Ulven, Stine M.

In: Molecular Nutrition & Food Research, Vol. 63, No. 13, 1801405, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Myhrstad, MCW, de Mello, VD, Dahlman, I, Kolehmainen, M, Paananen, J, Rundblad, A, Carlberg, C, Olstad, OK, Pihlajamäki, J, Holven, KB, Hermansen, K, Dragsted, LO, Gunnarsdottir, I, Cloetens, L, Storm, MU, Åkesson, B, Rosqvist, F, Hukkanen, J, Herzig, K-H, Risérus, U, Thorsdottir, I, Poutanen, KS, Savolainen, MJ, Schwab, U, Arner, P, Uusitupa, M & Ulven, SM 2019, 'Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study', Molecular Nutrition & Food Research, vol. 63, no. 13, 1801405. https://doi.org/10.1002/mnfr.201801405

APA

Myhrstad, M. C. W., de Mello, V. D., Dahlman, I., Kolehmainen, M., Paananen, J., Rundblad, A., ... Ulven, S. M. (2019). Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study. Molecular Nutrition & Food Research, 63(13), [1801405]. https://doi.org/10.1002/mnfr.201801405

Vancouver

Myhrstad MCW, de Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A et al. Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study. Molecular Nutrition & Food Research. 2019;63(13). 1801405. https://doi.org/10.1002/mnfr.201801405

Author

Myhrstad, Mari C W ; de Mello, Vanessa D ; Dahlman, Ingrid ; Kolehmainen, Marjukka ; Paananen, Jussi ; Rundblad, Amanda ; Carlberg, Carsten ; Olstad, Ole Kristoffer ; Pihlajamäki, Jussi ; Holven, Kirsten B ; Hermansen, Kjeld ; Dragsted, Lars Ove ; Gunnarsdottir, Ingibjörg ; Cloetens, Lieselotte ; Storm, Matilda Ulmius ; Åkesson, Björn ; Rosqvist, Fredrik ; Hukkanen, Janne ; Herzig, Karl-Heinz ; Risérus, Ulf ; Thorsdottir, Inga ; Poutanen, Kaisa S ; Savolainen, Markku J ; Schwab, Ursula ; Arner, Peter ; Uusitupa, Matti ; Ulven, Stine M. / Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study. In: Molecular Nutrition & Food Research. 2019 ; Vol. 63, No. 13.

Bibtex

@article{4314c0b8ffc14aa79d9ea6b3ce66341b,
title = "Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study",
abstract = "Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with the metabolic syndrome.Methods and Results: Subjects with the metabolic syndrome underwent an 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants were included. PBMCs were obtained before and after intervention and total RNA was subjected to global transcriptome analysis. 1302 probe sets were differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these were significantly regulated (FDR q-value < 0.25) and were mainly involved in mitochondrial function, cell growth and cell adhesion. The list of 1302 regulated probe sets was subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response and cell cycle were down-regulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors including NFR1, NFR2 and NF-κB, were down-regulated in the healthy Nordic diet group.Conclusion: These results suggests that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation. This article is protected by copyright. All rights reserved.",
keywords = "Faculty of Science, Healthy Nordic diet, Metabolic syndrome, PBMCs, Transcriptome, Gene-expression",
author = "Myhrstad, {Mari C W} and {de Mello}, {Vanessa D} and Ingrid Dahlman and Marjukka Kolehmainen and Jussi Paananen and Amanda Rundblad and Carsten Carlberg and Olstad, {Ole Kristoffer} and Jussi Pihlajam{\"a}ki and Holven, {Kirsten B} and Kjeld Hermansen and Dragsted, {Lars Ove} and Ingibj{\"o}rg Gunnarsdottir and Lieselotte Cloetens and Storm, {Matilda Ulmius} and Bj{\"o}rn {\AA}kesson and Fredrik Rosqvist and Janne Hukkanen and Karl-Heinz Herzig and Ulf Ris{\'e}rus and Inga Thorsdottir and Poutanen, {Kaisa S} and Savolainen, {Markku J} and Ursula Schwab and Peter Arner and Matti Uusitupa and Ulven, {Stine M}",
note = "CURIS 2019 NEXS 133 This article is protected by copyright. All rights reserved.",
year = "2019",
doi = "10.1002/mnfr.201801405",
language = "English",
volume = "63",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH",
number = "13",

}

RIS

TY - JOUR

T1 - Healthy Nordic diet modulates the expression of genes related to mitochondrial function and immune response in peripheral blood mononuclear cells from subjects with the metabolic syndrome - a SYSDIET sub-study

AU - Myhrstad, Mari C W

AU - de Mello, Vanessa D

AU - Dahlman, Ingrid

AU - Kolehmainen, Marjukka

AU - Paananen, Jussi

AU - Rundblad, Amanda

AU - Carlberg, Carsten

AU - Olstad, Ole Kristoffer

AU - Pihlajamäki, Jussi

AU - Holven, Kirsten B

AU - Hermansen, Kjeld

AU - Dragsted, Lars Ove

AU - Gunnarsdottir, Ingibjörg

AU - Cloetens, Lieselotte

AU - Storm, Matilda Ulmius

AU - Åkesson, Björn

AU - Rosqvist, Fredrik

AU - Hukkanen, Janne

AU - Herzig, Karl-Heinz

AU - Risérus, Ulf

AU - Thorsdottir, Inga

AU - Poutanen, Kaisa S

AU - Savolainen, Markku J

AU - Schwab, Ursula

AU - Arner, Peter

AU - Uusitupa, Matti

AU - Ulven, Stine M

N1 - CURIS 2019 NEXS 133 This article is protected by copyright. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with the metabolic syndrome.Methods and Results: Subjects with the metabolic syndrome underwent an 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants were included. PBMCs were obtained before and after intervention and total RNA was subjected to global transcriptome analysis. 1302 probe sets were differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these were significantly regulated (FDR q-value < 0.25) and were mainly involved in mitochondrial function, cell growth and cell adhesion. The list of 1302 regulated probe sets was subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response and cell cycle were down-regulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors including NFR1, NFR2 and NF-κB, were down-regulated in the healthy Nordic diet group.Conclusion: These results suggests that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation. This article is protected by copyright. All rights reserved.

AB - Scope: To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with the metabolic syndrome.Methods and Results: Subjects with the metabolic syndrome underwent an 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants were included. PBMCs were obtained before and after intervention and total RNA was subjected to global transcriptome analysis. 1302 probe sets were differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these were significantly regulated (FDR q-value < 0.25) and were mainly involved in mitochondrial function, cell growth and cell adhesion. The list of 1302 regulated probe sets was subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response and cell cycle were down-regulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors including NFR1, NFR2 and NF-κB, were down-regulated in the healthy Nordic diet group.Conclusion: These results suggests that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation. This article is protected by copyright. All rights reserved.

KW - Faculty of Science

KW - Healthy Nordic diet

KW - Metabolic syndrome

KW - PBMCs

KW - Transcriptome

KW - Gene-expression

U2 - 10.1002/mnfr.201801405

DO - 10.1002/mnfr.201801405

M3 - Journal article

C2 - 30964598

VL - 63

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 13

M1 - 1801405

ER -

ID: 216460579