Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study

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Standard

Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants : A pilot study. / Lind, Mads Vendelbo; Martino, D; Harsløf, Laurine Bente Schram; Kyjovska, Z O; Kristensen, Mette Bredal; Lauritzen, Lotte.

In: Prostaglandins, Leukotrienes & Essential Fatty Acids, Vol. 101, No. 1, 2015, p. 1-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Lind, MV, Martino, D, Harsløf, LBS, Kyjovska, ZO, Kristensen, MB & Lauritzen, L 2015, 'Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study', Prostaglandins, Leukotrienes & Essential Fatty Acids, vol. 101, no. 1, pp. 1-7. https://doi.org/10.1016/j.plefa.2015.07.003

APA

Lind, M. V., Martino, D., Harsløf, L. B. S., Kyjovska, Z. O., Kristensen, M. B., & Lauritzen, L. (2015). Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study. Prostaglandins, Leukotrienes & Essential Fatty Acids, 101(1), 1-7. https://doi.org/10.1016/j.plefa.2015.07.003

Vancouver

Lind MV, Martino D, Harsløf LBS, Kyjovska ZO, Kristensen MB, Lauritzen L. Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2015;101(1):1-7. https://doi.org/10.1016/j.plefa.2015.07.003

Author

Lind, Mads Vendelbo ; Martino, D ; Harsløf, Laurine Bente Schram ; Kyjovska, Z O ; Kristensen, Mette Bredal ; Lauritzen, Lotte. / Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants : A pilot study. In: Prostaglandins, Leukotrienes & Essential Fatty Acids. 2015 ; Vol. 101, No. 1. pp. 1-7.

Bibtex

@article{e697d51fed2d40fc9cb57b8d1357c11e,
title = "Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study",
abstract = "Recent evidence suggests that the effects of n-3LCPUFA might be mediated through epigenetic mechanisms, especially DNA-methylation, during pregnancy and early life. A randomized trial was conducted in 133 9-mo-old, infants who received 3.8g/day of fish oil (FO) or sunflower oil (SO) for 9 mo. In a subset of 12 children, buffy-coat DNA was extracted before and after intervention and analyzed on Illumina-Human-Methylation 450-arrays to explore genome-wide differences between the FO and SO groups. Genome-wide-methylation analysis did not reveal significant differences between groups after adjustment for multiple testing. However, analysis of the top-ranked CpG-sites revealed 43 CpG׳s that appear modified with an absolute difference in methylation of ≥10{\%}. Methylation levels at these sites were associated with phenotypic changes mainly in blood pressure. In conclusion, our analyses suggest potential epigenome effects that might be associated with functional outcomes, yet the effect sizes were small and should be verified by additional investigation.",
author = "Lind, {Mads Vendelbo} and D Martino and Harsl{\o}f, {Laurine Bente Schram} and Kyjovska, {Z O} and Kristensen, {Mette Bredal} and Lotte Lauritzen",
note = "CURIS 2015 NEXS 286",
year = "2015",
doi = "10.1016/j.plefa.2015.07.003",
language = "English",
volume = "101",
pages = "1--7",
journal = "Prostaglandins, Leukotrienes & Essential Fatty Acids",
issn = "0952-3278",
publisher = "Churchill Livingstone",
number = "1",

}

RIS

TY - JOUR

T1 - Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants

T2 - A pilot study

AU - Lind, Mads Vendelbo

AU - Martino, D

AU - Harsløf, Laurine Bente Schram

AU - Kyjovska, Z O

AU - Kristensen, Mette Bredal

AU - Lauritzen, Lotte

N1 - CURIS 2015 NEXS 286

PY - 2015

Y1 - 2015

N2 - Recent evidence suggests that the effects of n-3LCPUFA might be mediated through epigenetic mechanisms, especially DNA-methylation, during pregnancy and early life. A randomized trial was conducted in 133 9-mo-old, infants who received 3.8g/day of fish oil (FO) or sunflower oil (SO) for 9 mo. In a subset of 12 children, buffy-coat DNA was extracted before and after intervention and analyzed on Illumina-Human-Methylation 450-arrays to explore genome-wide differences between the FO and SO groups. Genome-wide-methylation analysis did not reveal significant differences between groups after adjustment for multiple testing. However, analysis of the top-ranked CpG-sites revealed 43 CpG׳s that appear modified with an absolute difference in methylation of ≥10%. Methylation levels at these sites were associated with phenotypic changes mainly in blood pressure. In conclusion, our analyses suggest potential epigenome effects that might be associated with functional outcomes, yet the effect sizes were small and should be verified by additional investigation.

AB - Recent evidence suggests that the effects of n-3LCPUFA might be mediated through epigenetic mechanisms, especially DNA-methylation, during pregnancy and early life. A randomized trial was conducted in 133 9-mo-old, infants who received 3.8g/day of fish oil (FO) or sunflower oil (SO) for 9 mo. In a subset of 12 children, buffy-coat DNA was extracted before and after intervention and analyzed on Illumina-Human-Methylation 450-arrays to explore genome-wide differences between the FO and SO groups. Genome-wide-methylation analysis did not reveal significant differences between groups after adjustment for multiple testing. However, analysis of the top-ranked CpG-sites revealed 43 CpG׳s that appear modified with an absolute difference in methylation of ≥10%. Methylation levels at these sites were associated with phenotypic changes mainly in blood pressure. In conclusion, our analyses suggest potential epigenome effects that might be associated with functional outcomes, yet the effect sizes were small and should be verified by additional investigation.

U2 - 10.1016/j.plefa.2015.07.003

DO - 10.1016/j.plefa.2015.07.003

M3 - Journal article

C2 - 26254087

VL - 101

SP - 1

EP - 7

JO - Prostaglandins, Leukotrienes & Essential Fatty Acids

JF - Prostaglandins, Leukotrienes & Essential Fatty Acids

SN - 0952-3278

IS - 1

ER -

ID: 142211011