Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects.

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Peptide YY (PYY)(3-36) has been shown to produce dramatic reductions in energy intake (EI), but no human data exist regarding energy expenditure (EE), glucose and fat metabolism. Nothing is known regarding PYY1-36. To compare effects of PYY(1-36) and PYY(3-36) on appetite, EI, EE, insulin, glucose and free fatty acids (FFA) concentrations, 12 lean and 12 obese males participated in a blinded, randomized, crossover study with 90-min infusions of saline, 0.8 pmol x kg(-1) x min(-1) PYY(1-36) and PYY(3-36). Only four participants completed PYY(3-36) infusions because of nausea. Subsequently, six lean and eight obese participants completed 0.2 pmol x kg(-1) x min(-1) PYY(3-36) and 1.6 pmol x kg(-1) x min(-1) PYY(1-36) infusions. PYY(3-36) [corrected] produced [corrected] lower ratings of well-being and [corrected] increases in heart rate, [corrected] FFA, and [corrected] postprandial [corrected] insulin concentrations. Furthermore, high-dose [corrected] PYY(3-36) (0.8 [corrected] pmol x kg(-1) x min(-1)) produced decreased [corrected] EI and increased postprandial [corrected] glucose concentrations and tendency to reduced EE [corrected]
Original languageEnglish
JournalAmerican Journal of Physiology: Endocrinology and Metabolism
Issue number4
Pages (from-to)E1062-E1068
Number of pages7
Publication statusPublished - 2006

Bibliographical note

Keywords: Adult; Appetite; Blood Glucose; Cross-Over Studies; Dose-Response Relationship, Drug; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; Heart Rate; Humans; Insulin; Lipolysis; Male; Obesity; Osmolar Concentration; Peptide YY; Postprandial Period; Thermogenesis

ID: 8072580