Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients : A twelve-month randomized controlled trial. / Christensen, Robin; Henriksen, Marius; Leeds, Anthony R; Gudbergsen, Henrik; Christensen, Pia; Sørensen, Tina J; Bartels, Else Marie; Riecke, Birgit F; Aaboe, Jens; Frederiksen, Rikke; Boesen, Mikael; Lohmander, L Stefan; Astrup, Arne; Bliddal, Henning.

In: Arthritis Care & Research, Vol. 67, No. 5, 2015, p. 640-650.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, R, Henriksen, M, Leeds, AR, Gudbergsen, H, Christensen, P, Sørensen, TJ, Bartels, EM, Riecke, BF, Aaboe, J, Frederiksen, R, Boesen, M, Lohmander, LS, Astrup, A & Bliddal, H 2015, 'Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial', Arthritis Care & Research, vol. 67, no. 5, pp. 640-650. https://doi.org/10.1002/acr.22504

APA

Christensen, R., Henriksen, M., Leeds, A. R., Gudbergsen, H., Christensen, P., Sørensen, T. J., Bartels, E. M., Riecke, B. F., Aaboe, J., Frederiksen, R., Boesen, M., Lohmander, L. S., Astrup, A., & Bliddal, H. (2015). Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial. Arthritis Care & Research, 67(5), 640-650. https://doi.org/10.1002/acr.22504

Vancouver

Christensen R, Henriksen M, Leeds AR, Gudbergsen H, Christensen P, Sørensen TJ et al. Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial. Arthritis Care & Research. 2015;67(5):640-650. https://doi.org/10.1002/acr.22504

Author

Christensen, Robin ; Henriksen, Marius ; Leeds, Anthony R ; Gudbergsen, Henrik ; Christensen, Pia ; Sørensen, Tina J ; Bartels, Else Marie ; Riecke, Birgit F ; Aaboe, Jens ; Frederiksen, Rikke ; Boesen, Mikael ; Lohmander, L Stefan ; Astrup, Arne ; Bliddal, Henning. / Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients : A twelve-month randomized controlled trial. In: Arthritis Care & Research. 2015 ; Vol. 67, No. 5. pp. 640-650.

Bibtex

@article{2b45f8dbfe3c44708c75ef80cea667ba,
title = "Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: A twelve-month randomized controlled trial",
abstract = "Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either Dietary support (D), knee-Exercise program (E), or Control (C) {"}no attention{"}. Methods Randomized, two-phase, parallel-group trial. 192 obese participants with knee OA were enrolled; mean age 62.5 y, 81% women with a mean entry weight of 103.2 kg. In phase-1, all participants were randomly assigned to one of three groups and began a dietary regimen of 400-810 and 1250 kcal/d for 8+8 weeks to achieve a major weight loss. Phase-2: 52 weeks maintenance in one of three groups D, E, or C. Outcomes: Changes from randomization in pain on a 100 mm Visual Analogue Scale, weight, and response according to OMERACT-OARSI criteria. Results Phase-1 mean weight loss was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 [95% CI: 9.0;12.8] kg) than those in the E (6.2 [4.4;8.1] kg), and C (8.2 [6.4;10.1] kg) groups (ANCOVA: P=.002). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; C: 5.5 mm) with no difference between groups (ANCOVA: P=.98). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment, in D, E, and C groups, respectively; with no statistically significant difference in the number of responders (P=.41). Conclusion A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program. {\textcopyright} 2014 American College of Rheumatology.",
author = "Robin Christensen and Marius Henriksen and Leeds, {Anthony R} and Henrik Gudbergsen and Pia Christensen and S{\o}rensen, {Tina J} and Bartels, {Else Marie} and Riecke, {Birgit F} and Jens Aaboe and Rikke Frederiksen and Mikael Boesen and Lohmander, {L Stefan} and Arne Astrup and Henning Bliddal",
note = "CURIS 2015 NEXS 181",
year = "2015",
doi = "10.1002/acr.22504",
language = "English",
volume = "67",
pages = "640--650",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients

T2 - A twelve-month randomized controlled trial

AU - Christensen, Robin

AU - Henriksen, Marius

AU - Leeds, Anthony R

AU - Gudbergsen, Henrik

AU - Christensen, Pia

AU - Sørensen, Tina J

AU - Bartels, Else Marie

AU - Riecke, Birgit F

AU - Aaboe, Jens

AU - Frederiksen, Rikke

AU - Boesen, Mikael

AU - Lohmander, L Stefan

AU - Astrup, Arne

AU - Bliddal, Henning

N1 - CURIS 2015 NEXS 181

PY - 2015

Y1 - 2015

N2 - Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either Dietary support (D), knee-Exercise program (E), or Control (C) "no attention". Methods Randomized, two-phase, parallel-group trial. 192 obese participants with knee OA were enrolled; mean age 62.5 y, 81% women with a mean entry weight of 103.2 kg. In phase-1, all participants were randomly assigned to one of three groups and began a dietary regimen of 400-810 and 1250 kcal/d for 8+8 weeks to achieve a major weight loss. Phase-2: 52 weeks maintenance in one of three groups D, E, or C. Outcomes: Changes from randomization in pain on a 100 mm Visual Analogue Scale, weight, and response according to OMERACT-OARSI criteria. Results Phase-1 mean weight loss was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 [95% CI: 9.0;12.8] kg) than those in the E (6.2 [4.4;8.1] kg), and C (8.2 [6.4;10.1] kg) groups (ANCOVA: P=.002). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; C: 5.5 mm) with no difference between groups (ANCOVA: P=.98). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment, in D, E, and C groups, respectively; with no statistically significant difference in the number of responders (P=.41). Conclusion A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program. © 2014 American College of Rheumatology.

AB - Objective To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either Dietary support (D), knee-Exercise program (E), or Control (C) "no attention". Methods Randomized, two-phase, parallel-group trial. 192 obese participants with knee OA were enrolled; mean age 62.5 y, 81% women with a mean entry weight of 103.2 kg. In phase-1, all participants were randomly assigned to one of three groups and began a dietary regimen of 400-810 and 1250 kcal/d for 8+8 weeks to achieve a major weight loss. Phase-2: 52 weeks maintenance in one of three groups D, E, or C. Outcomes: Changes from randomization in pain on a 100 mm Visual Analogue Scale, weight, and response according to OMERACT-OARSI criteria. Results Phase-1 mean weight loss was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 [95% CI: 9.0;12.8] kg) than those in the E (6.2 [4.4;8.1] kg), and C (8.2 [6.4;10.1] kg) groups (ANCOVA: P=.002). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; C: 5.5 mm) with no difference between groups (ANCOVA: P=.98). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment, in D, E, and C groups, respectively; with no statistically significant difference in the number of responders (P=.41). Conclusion A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program. © 2014 American College of Rheumatology.

U2 - 10.1002/acr.22504

DO - 10.1002/acr.22504

M3 - Journal article

C2 - 25370359

VL - 67

SP - 640

EP - 650

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 5

ER -

ID: 130285581