Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. / Goni, Leticia; Qi, Lu; Cuervo, Marta; Milagro, Fermín I; Saris, Wim H; Macdonald, Ian A; Langin, Dominique; Astrup, Arne; Arner, Peter; Oppert, Jean Michel; Svendstrup, Mathilde; Blaak, Ellen; Sørensen, Thorkild I. A.; Hansen, Torben; Martinez, J Alfredo.

In: American Journal of Clinical Nutrition, Vol. 106, No. 3, 2017, p. 902-908.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Goni, L, Qi, L, Cuervo, M, Milagro, FI, Saris, WH, Macdonald, IA, Langin, D, Astrup, A, Arner, P, Oppert, JM, Svendstrup, M, Blaak, E, Sørensen, TIA, Hansen, T & Martinez, JA 2017, 'Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial', American Journal of Clinical Nutrition, vol. 106, no. 3, pp. 902-908. https://doi.org/10.3945/ajcn.117.156281

APA

Goni, L., Qi, L., Cuervo, M., Milagro, F. I., Saris, W. H., Macdonald, I. A., Langin, D., Astrup, A., Arner, P., Oppert, J. M., Svendstrup, M., Blaak, E., Sørensen, T. I. A., Hansen, T., & Martinez, J. A. (2017). Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. American Journal of Clinical Nutrition, 106(3), 902-908. https://doi.org/10.3945/ajcn.117.156281

Vancouver

Goni L, Qi L, Cuervo M, Milagro FI, Saris WH, Macdonald IA et al. Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. American Journal of Clinical Nutrition. 2017;106(3):902-908. https://doi.org/10.3945/ajcn.117.156281

Author

Goni, Leticia ; Qi, Lu ; Cuervo, Marta ; Milagro, Fermín I ; Saris, Wim H ; Macdonald, Ian A ; Langin, Dominique ; Astrup, Arne ; Arner, Peter ; Oppert, Jean Michel ; Svendstrup, Mathilde ; Blaak, Ellen ; Sørensen, Thorkild I. A. ; Hansen, Torben ; Martinez, J Alfredo. / Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial. In: American Journal of Clinical Nutrition. 2017 ; Vol. 106, No. 3. pp. 902-908.

Bibtex

@article{ac42c956caf249db863f0248d4839169,
title = "Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial",
abstract = "Background: Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with insulin resistance and diabetes risk. The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene has been related to elevated BCAA concentrations and risk of type 2 diabetes.Objective: In the present study, we tested whether dietary fat and carbohydrate intakes influenced the association between the rs1440581 PPM1K genetic variant and glucose-metabolism traits during weight loss.Design: The rs1440581 PPM1K genetic variant was genotyped in a total of 757 nondiabetic individuals who were randomly assigned to 1 of 2 energy-restricted diets that differed in macronutrient composition (low-fat diet: 20-25% fat, 15% protein, and 60-65% carbohydrate; high-fat diet: 40-45% fat, 15% protein, and 40-45% carbohydrate). The changes in fasting glucose, fasting insulin, insulin resistance (homeostasis model assessment of insulin resistance) and homeostasis model assessment of β cell function (HOMA-B) were measured after a mean ± SD weight loss of 6.8 ± 3.4 kg over 10 wk and analyzed according to the presence of the T allele of rs1440581.Results: The rs1440581 T allele was associated with a smaller improvement in glucose concentrations after the 10-wk dietary intervention (β ± SE: 0.05 ± 0.02 mg/dL; P = 0.03). In addition, significant gene-diet interactions were shown for the rs1440581 PPM1K genetic variant in relation to changes in insulin and HOMA-B (P-interaction = 0.006 and 0.002, respectively). In response to the high-fat diet, the T allele was associated with a higher reduction of insulin (β ± SE: -0.77 ± 0.40 μU/mL; P = 0.04) and HOMA-B (β ± SE: -13.2 ± 3.81; P = 0.003). An opposite effect was observed in the low-fat diet group, although in this group the T allele was marginally (P = 0.10) and not significantly (P = 0.24) associated with insulin and HOMA-B, respectively.Conclusion:PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. This trial was registered at controlled-trials.com as ISRCTN25867281.",
keywords = "Gene-diet interaction, Glucose concentrations, NUGENOB, Obesity, Weight loss",
author = "Leticia Goni and Lu Qi and Marta Cuervo and Milagro, {Ferm{\'i}n I} and Saris, {Wim H} and Macdonald, {Ian A} and Dominique Langin and Arne Astrup and Peter Arner and Oppert, {Jean Michel} and Mathilde Svendstrup and Ellen Blaak and S{\o}rensen, {Thorkild I. A.} and Torben Hansen and Martinez, {J Alfredo}",
note = "CURIS 2017 NEXS 218",
year = "2017",
doi = "10.3945/ajcn.117.156281",
language = "English",
volume = "106",
pages = "902--908",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial

AU - Goni, Leticia

AU - Qi, Lu

AU - Cuervo, Marta

AU - Milagro, Fermín I

AU - Saris, Wim H

AU - Macdonald, Ian A

AU - Langin, Dominique

AU - Astrup, Arne

AU - Arner, Peter

AU - Oppert, Jean Michel

AU - Svendstrup, Mathilde

AU - Blaak, Ellen

AU - Sørensen, Thorkild I. A.

AU - Hansen, Torben

AU - Martinez, J Alfredo

N1 - CURIS 2017 NEXS 218

PY - 2017

Y1 - 2017

N2 - Background: Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with insulin resistance and diabetes risk. The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene has been related to elevated BCAA concentrations and risk of type 2 diabetes.Objective: In the present study, we tested whether dietary fat and carbohydrate intakes influenced the association between the rs1440581 PPM1K genetic variant and glucose-metabolism traits during weight loss.Design: The rs1440581 PPM1K genetic variant was genotyped in a total of 757 nondiabetic individuals who were randomly assigned to 1 of 2 energy-restricted diets that differed in macronutrient composition (low-fat diet: 20-25% fat, 15% protein, and 60-65% carbohydrate; high-fat diet: 40-45% fat, 15% protein, and 40-45% carbohydrate). The changes in fasting glucose, fasting insulin, insulin resistance (homeostasis model assessment of insulin resistance) and homeostasis model assessment of β cell function (HOMA-B) were measured after a mean ± SD weight loss of 6.8 ± 3.4 kg over 10 wk and analyzed according to the presence of the T allele of rs1440581.Results: The rs1440581 T allele was associated with a smaller improvement in glucose concentrations after the 10-wk dietary intervention (β ± SE: 0.05 ± 0.02 mg/dL; P = 0.03). In addition, significant gene-diet interactions were shown for the rs1440581 PPM1K genetic variant in relation to changes in insulin and HOMA-B (P-interaction = 0.006 and 0.002, respectively). In response to the high-fat diet, the T allele was associated with a higher reduction of insulin (β ± SE: -0.77 ± 0.40 μU/mL; P = 0.04) and HOMA-B (β ± SE: -13.2 ± 3.81; P = 0.003). An opposite effect was observed in the low-fat diet group, although in this group the T allele was marginally (P = 0.10) and not significantly (P = 0.24) associated with insulin and HOMA-B, respectively.Conclusion:PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. This trial was registered at controlled-trials.com as ISRCTN25867281.

AB - Background: Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with insulin resistance and diabetes risk. The common rs1440581 T allele in the protein phosphatase Mg2+/Mn2+ dependent 1K (PPM1K) gene has been related to elevated BCAA concentrations and risk of type 2 diabetes.Objective: In the present study, we tested whether dietary fat and carbohydrate intakes influenced the association between the rs1440581 PPM1K genetic variant and glucose-metabolism traits during weight loss.Design: The rs1440581 PPM1K genetic variant was genotyped in a total of 757 nondiabetic individuals who were randomly assigned to 1 of 2 energy-restricted diets that differed in macronutrient composition (low-fat diet: 20-25% fat, 15% protein, and 60-65% carbohydrate; high-fat diet: 40-45% fat, 15% protein, and 40-45% carbohydrate). The changes in fasting glucose, fasting insulin, insulin resistance (homeostasis model assessment of insulin resistance) and homeostasis model assessment of β cell function (HOMA-B) were measured after a mean ± SD weight loss of 6.8 ± 3.4 kg over 10 wk and analyzed according to the presence of the T allele of rs1440581.Results: The rs1440581 T allele was associated with a smaller improvement in glucose concentrations after the 10-wk dietary intervention (β ± SE: 0.05 ± 0.02 mg/dL; P = 0.03). In addition, significant gene-diet interactions were shown for the rs1440581 PPM1K genetic variant in relation to changes in insulin and HOMA-B (P-interaction = 0.006 and 0.002, respectively). In response to the high-fat diet, the T allele was associated with a higher reduction of insulin (β ± SE: -0.77 ± 0.40 μU/mL; P = 0.04) and HOMA-B (β ± SE: -13.2 ± 3.81; P = 0.003). An opposite effect was observed in the low-fat diet group, although in this group the T allele was marginally (P = 0.10) and not significantly (P = 0.24) associated with insulin and HOMA-B, respectively.Conclusion:PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. This trial was registered at controlled-trials.com as ISRCTN25867281.

KW - Gene-diet interaction

KW - Glucose concentrations

KW - NUGENOB

KW - Obesity

KW - Weight loss

U2 - 10.3945/ajcn.117.156281

DO - 10.3945/ajcn.117.156281

M3 - Journal article

C2 - 28768654

VL - 106

SP - 902

EP - 908

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -

ID: 182325822