Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study

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Standard

Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss : the DiOGenes randomized study. / Engberink, M F; Geleijnse, J M; Bakker, S J L; Larsen, Thomas Meinert; Handjieva-Darlesnka, T; Kafatos, A; Martinez, J A; Pfeiffer, A F H; Kunešová, M; Jebb, S A; Holst, Claus; Astrup, Arne; Saris, W H M; Brink, E J; van Baak, M A.

In: Journal of Human Hypertension, Vol. 29, No. 1, 2015, p. 58-63.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Engberink, MF, Geleijnse, JM, Bakker, SJL, Larsen, TM, Handjieva-Darlesnka, T, Kafatos, A, Martinez, JA, Pfeiffer, AFH, Kunešová, M, Jebb, SA, Holst, C, Astrup, A, Saris, WHM, Brink, EJ & van Baak, MA 2015, 'Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study', Journal of Human Hypertension, vol. 29, no. 1, pp. 58-63. https://doi.org/10.1038/jhh.2014.30

APA

Engberink, M. F., Geleijnse, J. M., Bakker, S. J. L., Larsen, T. M., Handjieva-Darlesnka, T., Kafatos, A., ... van Baak, M. A. (2015). Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study. Journal of Human Hypertension, 29(1), 58-63. https://doi.org/10.1038/jhh.2014.30

Vancouver

Engberink MF, Geleijnse JM, Bakker SJL, Larsen TM, Handjieva-Darlesnka T, Kafatos A et al. Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study. Journal of Human Hypertension. 2015;29(1):58-63. https://doi.org/10.1038/jhh.2014.30

Author

Engberink, M F ; Geleijnse, J M ; Bakker, S J L ; Larsen, Thomas Meinert ; Handjieva-Darlesnka, T ; Kafatos, A ; Martinez, J A ; Pfeiffer, A F H ; Kunešová, M ; Jebb, S A ; Holst, Claus ; Astrup, Arne ; Saris, W H M ; Brink, E J ; van Baak, M A. / Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss : the DiOGenes randomized study. In: Journal of Human Hypertension. 2015 ; Vol. 29, No. 1. pp. 58-63.

Bibtex

@article{e78e56912a8a45ffb78b7aeec000b0fd,
title = "Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study",
abstract = "Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight adults from the Diet, Obesity and Genes study. After an 8-week weight-loss period (>8{\%} BW), subjects (42±6 years) were randomized to either a high-protein diet (23-28 en{\%} protein) or a lower-protein control diet (10-15 en{\%} protein) for 26 weeks. BMI after weight loss was 30.3±4.3 kg m(-2), BP was 118/73 mm Hg and 28 subjects (6.5{\%}) used antihypertensive agents. Systolic BP during 26 weeks of weight maintenance dietary intervention increased in both treatment groups, but it was 2.2 mm Hg less (95{\%} CI: -4.6 to 0.2 mm Hg, P=0.08) in the high-protein group than in the lower-protein control group. In 191 (pre)hypertensive subjects (baseline systolic BP⩾120 mm Hg), a larger difference was observed (-4.2 mm Hg (-7.7, -0.7), P=0.02). The effect was attenuated after adjustment for initial BP (-3.4 mm Hg (-6.9, -0.03), P=0.048), and after additional adjustment for weight change (-2.7 mm Hg (-6.1, 0.4), P=0.11). Adjustment for 24-h urinary excretion of sodium and potassium did not change the results. Diastolic BP yielded similar results. These findings suggest that a BP reduction after weight loss is better maintained when the intake of protein is increased at the expense of carbohydrates. This effect is partly mediated by body weight.Journal of Human Hypertension advance online publication, 24 April 2014; doi:10.1038/jhh.2014.30.",
author = "Engberink, {M F} and Geleijnse, {J M} and Bakker, {S J L} and Larsen, {Thomas Meinert} and T Handjieva-Darlesnka and A Kafatos and Martinez, {J A} and Pfeiffer, {A F H} and M Kunešov{\'a} and Jebb, {S A} and Claus Holst and Arne Astrup and Saris, {W H M} and Brink, {E J} and {van Baak}, {M A}",
note = "CURIS 2015 NEXS 002",
year = "2015",
doi = "10.1038/jhh.2014.30",
language = "English",
volume = "29",
pages = "58--63",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss

T2 - the DiOGenes randomized study

AU - Engberink, M F

AU - Geleijnse, J M

AU - Bakker, S J L

AU - Larsen, Thomas Meinert

AU - Handjieva-Darlesnka, T

AU - Kafatos, A

AU - Martinez, J A

AU - Pfeiffer, A F H

AU - Kunešová, M

AU - Jebb, S A

AU - Holst, Claus

AU - Astrup, Arne

AU - Saris, W H M

AU - Brink, E J

AU - van Baak, M A

N1 - CURIS 2015 NEXS 002

PY - 2015

Y1 - 2015

N2 - Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight adults from the Diet, Obesity and Genes study. After an 8-week weight-loss period (>8% BW), subjects (42±6 years) were randomized to either a high-protein diet (23-28 en% protein) or a lower-protein control diet (10-15 en% protein) for 26 weeks. BMI after weight loss was 30.3±4.3 kg m(-2), BP was 118/73 mm Hg and 28 subjects (6.5%) used antihypertensive agents. Systolic BP during 26 weeks of weight maintenance dietary intervention increased in both treatment groups, but it was 2.2 mm Hg less (95% CI: -4.6 to 0.2 mm Hg, P=0.08) in the high-protein group than in the lower-protein control group. In 191 (pre)hypertensive subjects (baseline systolic BP⩾120 mm Hg), a larger difference was observed (-4.2 mm Hg (-7.7, -0.7), P=0.02). The effect was attenuated after adjustment for initial BP (-3.4 mm Hg (-6.9, -0.03), P=0.048), and after additional adjustment for weight change (-2.7 mm Hg (-6.1, 0.4), P=0.11). Adjustment for 24-h urinary excretion of sodium and potassium did not change the results. Diastolic BP yielded similar results. These findings suggest that a BP reduction after weight loss is better maintained when the intake of protein is increased at the expense of carbohydrates. This effect is partly mediated by body weight.Journal of Human Hypertension advance online publication, 24 April 2014; doi:10.1038/jhh.2014.30.

AB - Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight adults from the Diet, Obesity and Genes study. After an 8-week weight-loss period (>8% BW), subjects (42±6 years) were randomized to either a high-protein diet (23-28 en% protein) or a lower-protein control diet (10-15 en% protein) for 26 weeks. BMI after weight loss was 30.3±4.3 kg m(-2), BP was 118/73 mm Hg and 28 subjects (6.5%) used antihypertensive agents. Systolic BP during 26 weeks of weight maintenance dietary intervention increased in both treatment groups, but it was 2.2 mm Hg less (95% CI: -4.6 to 0.2 mm Hg, P=0.08) in the high-protein group than in the lower-protein control group. In 191 (pre)hypertensive subjects (baseline systolic BP⩾120 mm Hg), a larger difference was observed (-4.2 mm Hg (-7.7, -0.7), P=0.02). The effect was attenuated after adjustment for initial BP (-3.4 mm Hg (-6.9, -0.03), P=0.048), and after additional adjustment for weight change (-2.7 mm Hg (-6.1, 0.4), P=0.11). Adjustment for 24-h urinary excretion of sodium and potassium did not change the results. Diastolic BP yielded similar results. These findings suggest that a BP reduction after weight loss is better maintained when the intake of protein is increased at the expense of carbohydrates. This effect is partly mediated by body weight.Journal of Human Hypertension advance online publication, 24 April 2014; doi:10.1038/jhh.2014.30.

U2 - 10.1038/jhh.2014.30

DO - 10.1038/jhh.2014.30

M3 - Journal article

C2 - 24759040

VL - 29

SP - 58

EP - 63

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 1

ER -

ID: 109029741