Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

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Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. / Jiang, Rong; Brummett, Beverly H; Hauser, Elizabeth R; Babyak, Michael A; Siegler, Ilene C; Singh, Abanish; Astrup, Arne; Pedersen, Oluf; Hansen, Torben; Holst, Claus; Sørensen, Thorkild I A; Williams, Redford B.

In: Biological Psychology, Vol. 93, No. 1, 2013, p. 184-189.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jiang, R, Brummett, BH, Hauser, ER, Babyak, MA, Siegler, IC, Singh, A, Astrup, A, Pedersen, O, Hansen, T, Holst, C, Sørensen, TIA & Williams, RB 2013, 'Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples', Biological Psychology, vol. 93, no. 1, pp. 184-189. https://doi.org/10.1016/j.biopsycho.2013.02.006

APA

Jiang, R., Brummett, B. H., Hauser, E. R., Babyak, M. A., Siegler, I. C., Singh, A., ... Williams, R. B. (2013). Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. Biological Psychology, 93(1), 184-189. https://doi.org/10.1016/j.biopsycho.2013.02.006

Vancouver

Jiang R, Brummett BH, Hauser ER, Babyak MA, Siegler IC, Singh A et al. Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. Biological Psychology. 2013;93(1):184-189. https://doi.org/10.1016/j.biopsycho.2013.02.006

Author

Jiang, Rong ; Brummett, Beverly H ; Hauser, Elizabeth R ; Babyak, Michael A ; Siegler, Ilene C ; Singh, Abanish ; Astrup, Arne ; Pedersen, Oluf ; Hansen, Torben ; Holst, Claus ; Sørensen, Thorkild I A ; Williams, Redford B. / Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. In: Biological Psychology. 2013 ; Vol. 93, No. 1. pp. 184-189.

Bibtex

@article{126b379c0b8748b0880d5f27806876e2,
title = "Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples",
abstract = "TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.",
author = "Rong Jiang and Brummett, {Beverly H} and Hauser, {Elizabeth R} and Babyak, {Michael A} and Siegler, {Ilene C} and Abanish Singh and Arne Astrup and Oluf Pedersen and Torben Hansen and Claus Holst and S{\o}rensen, {Thorkild I A} and Williams, {Redford B}",
note = "CURIS 2013 NEXS 055",
year = "2013",
doi = "10.1016/j.biopsycho.2013.02.006",
language = "English",
volume = "93",
pages = "184--189",
journal = "Biological Psychology",
issn = "0301-0511",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

AU - Jiang, Rong

AU - Brummett, Beverly H

AU - Hauser, Elizabeth R

AU - Babyak, Michael A

AU - Siegler, Ilene C

AU - Singh, Abanish

AU - Astrup, Arne

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holst, Claus

AU - Sørensen, Thorkild I A

AU - Williams, Redford B

N1 - CURIS 2013 NEXS 055

PY - 2013

Y1 - 2013

N2 - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.

AB - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.

U2 - 10.1016/j.biopsycho.2013.02.006

DO - 10.1016/j.biopsycho.2013.02.006

M3 - Journal article

C2 - 23435269

VL - 93

SP - 184

EP - 189

JO - Biological Psychology

JF - Biological Psychology

SN - 0301-0511

IS - 1

ER -

ID: 44853343