Can we prevent obesity-related metabolic diseases by dietary modulation of the gut microbiota?

Research output: Contribution to journalReviewResearchpeer-review

  • Lena Kirchner Brahe
  • Arne Astrup
  • Lesli Hingstrup Larsen

Obesity increases the risk of type 2 diabetes, cardiovascular diseases, and certain cancers, which are among the leading causes of death worldwide. Obesity and obesity-related metabolic diseases are characterized by specific alterations in the human gut microbiota. Experimental studies with gut microbiota transplantations in mice and in humans indicate that a specific gut microbiota composition can be the cause and not just the consequence of the obese state and metabolic disease, which suggests a potential for gut microbiota modulation in prevention and treatment of obesity-related metabolic diseases. In addition, dietary intervention studies have suggested that modulation of the gut microbiota can improve metabolic risk markers in humans, but a causal role of the gut microbiota in such studies has not yet been established. Here, we review and discuss the role of the gut microbiota in obesity-related metabolic diseases and the potential of dietary modulation of the gut microbiota in metabolic disease prevention and treatment.

Original languageEnglish
JournalAdvances in Nutrition
Issue number1
Pages (from-to)90-101
Number of pages12
Publication statusPublished - 2016

ID: 154143396