An isocaloric Nordic diet modulates RELA and TNFRSF1A gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome - a SYSDIET sub-study
Research output: Contribution to journal › Journal article › Research › peer-review
- Ulven et al_Nutrients_2019_Vol 11(12)_02932
Final published version, 1.07 MB, PDF document
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.
|Number of pages||11|
|Publication status||Published - 2019|
- Faculty of Science - Metabolic syndrome, Randomized controlled dietary intervention, Gene expression, Peripheral blood mononuclear cells, Inflammation