An isocaloric Nordic diet modulates RELA and TNFRSF1A gene expression in peripheral blood mononuclear cells in individuals with metabolic syndrome - a SYSDIET sub-study

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  • Stine M Ulven
  • Kirsten B Holven
  • Amanda Rundblad
  • Mari C W Myhrstad
  • Lena Leder
  • Ingrid Dahlman
  • Vanessa D de Mello
  • Ursula Schwab
  • Carsten Carlberg
  • Jussi Pihlajamäki
  • Kjeld Hermansen
  • Ingibjörg Gunnarsdottir
  • Lieselotte Cloetens
  • Björn Åkesson
  • Fredrik Rosqvist
  • Janne Hukkanen
  • Karl-Heinz Herzig
  • Markku J Savolainen
  • Ulf Risérus
  • Inga Thorsdottir
  • Kaisa S Poutanen
  • Peter Arner
  • Matti Uusitupa
  • Marjukka Kolehmainen

A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELA proto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.

Original languageEnglish
Article number2932
Issue number12
Number of pages11
Publication statusPublished - 2019

    Research areas

  • Faculty of Science - Metabolic syndrome, Randomized controlled dietary intervention, Gene expression, Peripheral blood mononuclear cells, Inflammation

ID: 237652570