A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy

Research output: Contribution to journalJournal articleResearchpeer-review

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A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy. / Pedersen, Anne Kathrine Nissen; Rud, Charlotte; Wilkens, Trine Levring; Borre, Mette; Andersen, Jens Rikardt; Dahlerup, Jens Frederik; Hvas, Christian Lodberg.

In: Journal of Parenteral and Enteral Nutrition, 15.04.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pedersen, AKN, Rud, C, Wilkens, TL, Borre, M, Andersen, JR, Dahlerup, JF & Hvas, CL 2019, 'A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy' Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1593

APA

Pedersen, A. K. N., Rud, C., Wilkens, T. L., Borre, M., Andersen, J. R., Dahlerup, J. F., & Hvas, C. L. (2019). A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy. Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1593

Vancouver

Pedersen AKN, Rud C, Wilkens TL, Borre M, Andersen JR, Dahlerup JF et al. A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy. Journal of Parenteral and Enteral Nutrition. 2019 Apr 15. https://doi.org/10.1002/jpen.1593

Author

Pedersen, Anne Kathrine Nissen ; Rud, Charlotte ; Wilkens, Trine Levring ; Borre, Mette ; Andersen, Jens Rikardt ; Dahlerup, Jens Frederik ; Hvas, Christian Lodberg. / A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy. In: Journal of Parenteral and Enteral Nutrition. 2019.

Bibtex

@article{a028745d368d49f998dbef0ceb82d11c,
title = "A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy",
abstract = "Background: Sodium deficiency in patients with an ileostomy is associated with chronic dehydration and may be difficult to detect. We aimed to investigate if the sodium concentration in a single spot urine sample may be used as a proxy for 24-hour urine sodium excretion.Methods: In a prospective observational study with 8 patients with an ileostomy and 8 volunteers with intact intestines, we investigated the correlations and agreements between spot urine sodium concentrations and 24-hour urine sodium excretions. Spot urine samples were drawn from every micturition during 24 hours, and relevant blood samples were drawn. All participants documented their food and fluid intakes.Results: There was a high and statistically significant correlation between 24-hour natriuresis and urine sodium concentrations in both morning spot samples (n = 8, Spearman's rho [ρ] = 0.78, P = 0.03) and midday spot samples (n = 8, ρ = 0.82, P = 0.02) in the patients with an ileostomy. The agreement between methods was fair (bias = -1.5, limits of agreement = -32.3 to 29.4). There were no statistically significant associations for evening samples or for samples from volunteers with intact intestines independently of time of day.Conclusion: A single spot urine sodium sample obtained in the morning or midday may estimate 24-hour urine sodium excretion in patients with an ileostomy and thus help to identify sodium depletion.",
keywords = "The Faculty of Science, Dehydration, Ileostomy, Natriuresis, Short bowel syndrome, Water-electrolyte balance",
author = "Pedersen, {Anne Kathrine Nissen} and Charlotte Rud and Wilkens, {Trine Levring} and Mette Borre and Andersen, {Jens Rikardt} and Dahlerup, {Jens Frederik} and Hvas, {Christian Lodberg}",
note = "CURIS 2019 NEXS 128 {\circledC} 2019 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition.",
year = "2019",
month = "4",
day = "15",
doi = "10.1002/jpen.1593",
language = "English",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - A single urine sodium measurement may validly estimate 24-hour urine sodium excretion in patients with an ileostomy

AU - Pedersen, Anne Kathrine Nissen

AU - Rud, Charlotte

AU - Wilkens, Trine Levring

AU - Borre, Mette

AU - Andersen, Jens Rikardt

AU - Dahlerup, Jens Frederik

AU - Hvas, Christian Lodberg

N1 - CURIS 2019 NEXS 128 © 2019 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition.

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Background: Sodium deficiency in patients with an ileostomy is associated with chronic dehydration and may be difficult to detect. We aimed to investigate if the sodium concentration in a single spot urine sample may be used as a proxy for 24-hour urine sodium excretion.Methods: In a prospective observational study with 8 patients with an ileostomy and 8 volunteers with intact intestines, we investigated the correlations and agreements between spot urine sodium concentrations and 24-hour urine sodium excretions. Spot urine samples were drawn from every micturition during 24 hours, and relevant blood samples were drawn. All participants documented their food and fluid intakes.Results: There was a high and statistically significant correlation between 24-hour natriuresis and urine sodium concentrations in both morning spot samples (n = 8, Spearman's rho [ρ] = 0.78, P = 0.03) and midday spot samples (n = 8, ρ = 0.82, P = 0.02) in the patients with an ileostomy. The agreement between methods was fair (bias = -1.5, limits of agreement = -32.3 to 29.4). There were no statistically significant associations for evening samples or for samples from volunteers with intact intestines independently of time of day.Conclusion: A single spot urine sodium sample obtained in the morning or midday may estimate 24-hour urine sodium excretion in patients with an ileostomy and thus help to identify sodium depletion.

AB - Background: Sodium deficiency in patients with an ileostomy is associated with chronic dehydration and may be difficult to detect. We aimed to investigate if the sodium concentration in a single spot urine sample may be used as a proxy for 24-hour urine sodium excretion.Methods: In a prospective observational study with 8 patients with an ileostomy and 8 volunteers with intact intestines, we investigated the correlations and agreements between spot urine sodium concentrations and 24-hour urine sodium excretions. Spot urine samples were drawn from every micturition during 24 hours, and relevant blood samples were drawn. All participants documented their food and fluid intakes.Results: There was a high and statistically significant correlation between 24-hour natriuresis and urine sodium concentrations in both morning spot samples (n = 8, Spearman's rho [ρ] = 0.78, P = 0.03) and midday spot samples (n = 8, ρ = 0.82, P = 0.02) in the patients with an ileostomy. The agreement between methods was fair (bias = -1.5, limits of agreement = -32.3 to 29.4). There were no statistically significant associations for evening samples or for samples from volunteers with intact intestines independently of time of day.Conclusion: A single spot urine sodium sample obtained in the morning or midday may estimate 24-hour urine sodium excretion in patients with an ileostomy and thus help to identify sodium depletion.

KW - The Faculty of Science

KW - Dehydration

KW - Ileostomy

KW - Natriuresis

KW - Short bowel syndrome

KW - Water-electrolyte balance

U2 - 10.1002/jpen.1593

DO - 10.1002/jpen.1593

M3 - Journal article

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

ER -

ID: 216825279