A high rate of non-compliance confounds the study of whole grains and weight maintenance in a randomised intervention trial - the case for greater use of dietary biomarkers in nutrition intervention studies

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  • Mette Bredal Kristensen
  • Xavier Pelletier
  • Alastair B. Ross
  • Frank Thielecke

Observational studies consistently find an inverse relationship between whole-grain intake and weight gain. We aimed to confirm this in an open-label researcher-blinded parallel design randomised trial. A total of 179 overweight/obese women with a habitually low whole-grain intake (<16 %, %; (0.7 (80 (rg) (sd (wg) -0.3 12 12-week 3.6) 3.8) 8 a abdominal after alkylresorcinol an and assessed at baseline, biomarkers body changes compared compliance, composition concentrations, day) diet dietary differences during fat foods for g group group, in increase indicated initial intake, intervention intervention. loss loss, maintenance mass more no of or over p="0.052)." particularly phase phase, plasma poor program randomised refined-grain rg rye tended the there to total vs. was weeks weeks. weight were wg wheat where whereas whole-grain wholegrain with>60% of participants had alkylresorcinol concentrations below 70 nmol/L, a concentration indicating low or no intake of whole-grain wheat. Further, weight regain was lower than expected in both intervention groups, further supporting a lack of compliance to the post-weight-loss diet. The rate of compliance was too low to conclude any effect of whole grain on weight maintenance, and reinforces the need to use objective measures of compliance in nutrition intervention studies.

Original languageEnglish
Article number55
Issue number1
Number of pages14
Publication statusPublished - 2017

    Research areas

  • Faculty of Science - Whole grain, Weight maintenance, Compliance, Biomarkers, Alkylresorcinols

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