4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. / Bunch, Lennart; Pickering, Darryl S; Gefflaut, Thierry; Vinatier, Virginie; Helaine, Virgil; Amir, Ahmad; Nielsen, Birgitte; Jensen, Anders Asbjørn.

In: ChemMedChem, Vol. 4, No. 11, 2009, p. 1925-1929.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Bunch, L, Pickering, DS, Gefflaut, T, Vinatier, V, Helaine, V, Amir, A, Nielsen, B & Jensen, AA 2009, '4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters', ChemMedChem, vol. 4, no. 11, pp. 1925-1929. https://doi.org/10.1002/cmdc.200900258

APA

Bunch, L., Pickering, D. S., Gefflaut, T., Vinatier, V., Helaine, V., Amir, A., ... Jensen, A. A. (2009). 4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. ChemMedChem, 4(11), 1925-1929. https://doi.org/10.1002/cmdc.200900258

Vancouver

Bunch L, Pickering DS, Gefflaut T, Vinatier V, Helaine V, Amir A et al. 4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. ChemMedChem. 2009;4(11):1925-1929. https://doi.org/10.1002/cmdc.200900258

Author

Bunch, Lennart ; Pickering, Darryl S ; Gefflaut, Thierry ; Vinatier, Virginie ; Helaine, Virgil ; Amir, Ahmad ; Nielsen, Birgitte ; Jensen, Anders Asbjørn. / 4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters. In: ChemMedChem. 2009 ; Vol. 4, No. 11. pp. 1925-1929.

Bibtex

@article{77917be001d111df825d000ea68e967b,
title = "4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters",
abstract = "Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether this approach has provided important insight into the structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs), as well as the excitatory amino acid transporters (EAATs). In this work, three 4,4-disubstituted Glu analogues 1-3, which are hybrid structures of important 4-substituted Glu analogues 4-8, were investigated at iGluRs and EAATs. Collectively, their pharmacological profiles add new and valuable information to the SAR for the iGluRs and EAAT1-3.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Lennart Bunch and Pickering, {Darryl S} and Thierry Gefflaut and Virginie Vinatier and Virgil Helaine and Ahmad Amir and Birgitte Nielsen and Jensen, {Anders Asbj{\o}rn}",
year = "2009",
doi = "10.1002/cmdc.200900258",
language = "English",
volume = "4",
pages = "1925--1929",
journal = "ChemMedChem",
issn = "1860-7179",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "11",

}

RIS

TY - JOUR

T1 - 4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

AU - Bunch, Lennart

AU - Pickering, Darryl S

AU - Gefflaut, Thierry

AU - Vinatier, Virginie

AU - Helaine, Virgil

AU - Amir, Ahmad

AU - Nielsen, Birgitte

AU - Jensen, Anders Asbjørn

PY - 2009

Y1 - 2009

N2 - Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether this approach has provided important insight into the structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs), as well as the excitatory amino acid transporters (EAATs). In this work, three 4,4-disubstituted Glu analogues 1-3, which are hybrid structures of important 4-substituted Glu analogues 4-8, were investigated at iGluRs and EAATs. Collectively, their pharmacological profiles add new and valuable information to the SAR for the iGluRs and EAAT1-3.

AB - Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether this approach has provided important insight into the structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs), as well as the excitatory amino acid transporters (EAATs). In this work, three 4,4-disubstituted Glu analogues 1-3, which are hybrid structures of important 4-substituted Glu analogues 4-8, were investigated at iGluRs and EAATs. Collectively, their pharmacological profiles add new and valuable information to the SAR for the iGluRs and EAAT1-3.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/cmdc.200900258

DO - 10.1002/cmdc.200900258

M3 - Journal article

C2 - 19731281

VL - 4

SP - 1925

EP - 1929

JO - ChemMedChem

JF - ChemMedChem

SN - 1860-7179

IS - 11

ER -

ID: 17007204