1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. / Butini, Stefania; Pickering, Darryl S; Morelli, Elena; Coccone, Salvatore Sanna; Trotta, Francesco; De Angelis, Meri; Guarino, Egeria; Fiorini, Isabella; Campiani, Giuseppe; Novellino, Ettore; Schousboe, Arne; Christensen, Jeppe K; Gemma, Sandra.

In: Journal of Medicinal Chemistry, Vol. 51, No. 20, 2008, p. 6614-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Butini, S, Pickering, DS, Morelli, E, Coccone, SS, Trotta, F, De Angelis, M, Guarino, E, Fiorini, I, Campiani, G, Novellino, E, Schousboe, A, Christensen, JK & Gemma, S 2008, '1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators', Journal of Medicinal Chemistry, vol. 51, no. 20, pp. 6614-8. https://doi.org/10.1021/jm800865a

APA

Butini, S., Pickering, D. S., Morelli, E., Coccone, S. S., Trotta, F., De Angelis, M., ... Gemma, S. (2008). 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. Journal of Medicinal Chemistry, 51(20), 6614-8. https://doi.org/10.1021/jm800865a

Vancouver

Butini S, Pickering DS, Morelli E, Coccone SS, Trotta F, De Angelis M et al. 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. Journal of Medicinal Chemistry. 2008;51(20):6614-8. https://doi.org/10.1021/jm800865a

Author

Butini, Stefania ; Pickering, Darryl S ; Morelli, Elena ; Coccone, Salvatore Sanna ; Trotta, Francesco ; De Angelis, Meri ; Guarino, Egeria ; Fiorini, Isabella ; Campiani, Giuseppe ; Novellino, Ettore ; Schousboe, Arne ; Christensen, Jeppe K ; Gemma, Sandra. / 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. In: Journal of Medicinal Chemistry. 2008 ; Vol. 51, No. 20. pp. 6614-8.

Bibtex

@article{784ada00a04211dd86a6000ea68e967b,
title = "1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators",
abstract = "(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Stefania Butini and Pickering, {Darryl S} and Elena Morelli and Coccone, {Salvatore Sanna} and Francesco Trotta and {De Angelis}, Meri and Egeria Guarino and Isabella Fiorini and Giuseppe Campiani and Ettore Novellino and Arne Schousboe and Christensen, {Jeppe K} and Sandra Gemma",
year = "2008",
doi = "10.1021/jm800865a",
language = "English",
volume = "51",
pages = "6614--8",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "20",

}

RIS

TY - JOUR

T1 - 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators

AU - Butini, Stefania

AU - Pickering, Darryl S

AU - Morelli, Elena

AU - Coccone, Salvatore Sanna

AU - Trotta, Francesco

AU - De Angelis, Meri

AU - Guarino, Egeria

AU - Fiorini, Isabella

AU - Campiani, Giuseppe

AU - Novellino, Ettore

AU - Schousboe, Arne

AU - Christensen, Jeppe K

AU - Gemma, Sandra

PY - 2008

Y1 - 2008

N2 - (S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.

AB - (S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Derivatives 5 and 7, with their unique pharmacological profile, may lead to a better understanding of the different roles and modes of action of iGluR1-5 subunits, paving the way for the synthesis of new potent, subunit selective iGluR5 modulators.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/jm800865a

DO - 10.1021/jm800865a

M3 - Journal article

C2 - 18811139

VL - 51

SP - 6614

EP - 6618

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 20

ER -

ID: 6747715