Metabolomics Core Facility

Metabolomics Core Facility at Department of Nutrition, Exercise and Sports is an initiative aiming to support research in biomarkers for diseases, foods, microbiota and the connection between them.

The metabolomic core facility mainly covers

  • Method development (targeted and untargeted)
  • Food- and Nutritional metabolomics
  • Clinical metabolomics.

Together these fields offer a great potential to investigate metabolic changes. The primary research aim is to elucidate biological mechanisms in nutrition and to develop novel biomarkers for single foods or whole diets by the use of explorative metabolomics.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Combined urinary biomarkers to assess coffee intake using untargeted metabolomics: Discovery in three pilot human intervention studies and validation in cross-sectional studies

Discovery of urinary biomarkers of seaweed intake using untargeted LC-MS metabolomics in a three-way cross-over human study

The anserine to carnosine ratio: an excellent discriminator between white and red meats consumed by free-living overweight participants of the PREVIEW study

Biomarkers of intake for tropical fruits

Urine Metabolome Profiling Reveals Imprints of Food Heating Processes after Dietary Intervention with Differently Cooked PotatoesJ. Agric. Food Chem, 2020.

Biomarkers of meat and seafood intake: an extensive literature review

Biomarkers of seaweed intake

Biomarkers of tuber intake

Combined markers to assess meat intake - human metabolomic studies of discovery and validation

Discovery and validation of banana intake biomarkers using untargeted metabolomics in human intervention and cross-sectional studies

Biomarkers of food intake for Alliumvegetables

Food intake biomarkers for apple, pear, and stone fruit

Validation of biomarkers of food intake − critical assessment of candidate biomarkers

A scheme for a flexible classification of dietary and health biomarkersGenes Nutr. 2017

Dietary and health biomarkers - time for an update

Detecting beer intake by unique metabolite patterns

Identification of urinary biomarkers after consumption of sea buckthorn and strawberry, by untargeted LC-MS metabolomics: a meal study in adult men

Discovery and validation of urinary exposure markers for different plant foods by untargeted metabolomics

Effect of cheese and butter intake on metabolites in urine using an untargeted metabolomics approach

Untargeted metabolomics as a screening tool for estimating compliance to a dietary pattern

A LC-MS metabolomics approach to investigate the effect of raw apple intake in the rat plasma metabolomeMetabolomics, 2013. 

Discovery of exposure markers in urine for Brassica-containing meals served with different protein sources by UPLC-qTOF-MS untargeted metabolomics, Metabolomics, 2013.

UPLC-QTOF/MS Metabolic Profiling Unveils Urinary Changes in Humans after a Whole Grain Rye versus Refined Wheat Bread Intervention. Mol. Nutr. Food Res, 2013.

Biomarkers of meat intake and the application of nutrigenomics. Meat Sci, 2010.

An exploratory NMR nutri-metabonomic investigation reveals dimethylsulfone as a dietary biomarker for onion intake. Analyst, 2009.

 

 

 

 

 

 

 

 

 

 

Data sharing in PredRet for accurate prediction of retention time: Application to plant food bioactive compounds

Comparison of bi- and tri-linear PLS models for variable selection in metabolomic time-series experiments

The metaRbolomics toolbox in bioconductor and beyondMetabolites, 2019.

Dried urine swabs as a tool for monitoring metabolite excretion

A versatile UHPLC–MSMS method for simultaneous quantification of various alcohol intake related compounds in human urine and blood

PredRet: Prediction of Retention Time by Direct Mapping between Multiple Chromatographic SystemsAnal. Chem., 2015.

Metabolite profiling and beyond: Approaches for the rapid processing and annotation of human blood serum mass spectrometry data. Anal Bioanal Chem, 2013 (accepted).

UPLC-ESI-QTOF/MS and multivariate data analysis for blood plasma and serum metabolomics: effect of experimental artefacts and anticoagulant. Analyt. Chim. Acta, 2013 (accepted).

Coupled Matrix Factorization with Sparse Factors to Identify Potential Biomarkers in Metabolomics. International Journal of Knowledge Discovery in Bioinformatics. IEEE 12th International Conference on Data Mining Workshops. 2012.

Metabolic fingerprinting of high-fat plasma samples processed by centrifugation- and filtration-based protein precipitation delineates significant differences in metabolite information coverage. Analytica Chimica Acta, 2012.

Standardization of factors that influence human urine metabolomics, Metabolomics, 2011.

The Effect of LC-MS Data Preprocessing Methods on the Selection of Plasma Biomarkers in Fed vs. Fasted Rats. Metabolites, 2011.

NMR and iPLS are reliable methods for determination of cholesterol in rodent lipoprotein fractions. Metabolomics, 2009.

 

 

 

 

Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans - A randomized, 3-way, blinded, cross-over meal study

New advanced glycation end products observed in rat urine by untargeted metabolomics after feeding with heat-treated skimmed milk powder

Breastmilk lipids and oligosaccharides influence branched short-chain fatty acid concentrations in infants with excessive weight gain

Pre-meal protein intake alters postprandial plasma metabolome in subjects with metabolic syndrome

The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study

Biomarkers of individual foods, and separation of diets using untargeted LC-MS-based plasma metabolomics in a randomized controlled trial

Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Progressive changes in the plasma metabolome during malnutrition in juvenile pigs

An explorative study of the effect of apple and apple products on the human plasma metabolome investigated by LC-MS profiling

Whey protein delays gastric emptying and suppresses plasma fatty acids and their metabolites compared to casein, gluten, and fish protein

Intakes of whey protein hydrolysate and whole whey proteins are discriminated by LC-MS metabolomics

Patterns of time since last meal revealed by sparse PCA in an observational LC-MS based metabolomics study.Metabolomics, 2013.

LC-QTOF/MS metabolomic profiles in human plasma after a five-week high dietary fiber intake. Anal Bioanal Chem, 2013.

Assessment of dietary exposure related to dietary GI and fibre intake in a nutritional metabolomic study of human urine. Genes Nutr, 2012.

Assessment of the effect of high or low protein diet on the human urine metabolome by NMR. Nutrients, 2012.

LC–MS metabolomics top-down approach reveals new exposure and effect biomarkers of apple and apple-pectin intake. Metabolomics, 2012..

Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome. Fd. Chem. Toxicol, 2008.

 

 

 

 

 

 

 

Involved in Metabolomics Core Facility

Name Title Phone E-mail
Catalina Sinziana Cuparencu Postdoc   E-mail
Henrik Munch Roager Associate Professor +4535324928 E-mail
Jan Stanstrup Assistant Professor +4535332859 E-mail
Lars Ove Dragsted Head of Section +4535332694 E-mail

Contact

Professor Lars Ove Dragsted

More infomation

For more information about current research look at specific research groups