The impact of training and exercise on vascular growth and peripheral vascular function in skeletal muscle of subjects with essential hypertension
Ane Håkansson Hansen
2010, 123 pages, DKR 100
ISBN: 978 87 917 7128 6
Essential hypertension is a cardiovascular disease with no simple identifiable cause and the underlying mechanisms are still unclear. In general, the elevation of the blood pressure includes a major risk factor for myocardial infarction and stroke. The present thesis examined the effects of acute exercise and regular training in hypertensive subjects. The thesis covers 3 main areas: 1) vascular growth, 2) regulation of peripheral vascular function and 3) capillary basement membrane remodelling. These areas were examined in skeletal muscle in subjects participating in a four month training program
The major novel finding of this thesis is that a period of regular training is associated with improved angiogenic potential, enhanced vascular growth and improved vascular function. These alterations are paralleled by a lowering of blood pressure indicating a beneficial effect of training that may be associated with improving the regulation of total peripheral resistance.