Focus of Molecular signaling in muscle metabolism
Our research focus on the mechanism(s) by which physical activity promotes metabolic health. Our studies have focused on the role of the energy sensor AMP activated protein kinase in promoting adaptations in skeletal muscle to exercise training and to a single bout of exercise.
Of particular interest is the interaction at the intracellular level between exercise-induced signaling events and those induced by insulin trying to elucidate the mechanisms by which a single bout of exercise can improve muscle insulin sensitivity.
Our interest in energy metabolism is focused on the regulation of turnover and storage of both glucose and fatty acids.
Our approaches to gain such insights include invasive studies of healthy and diseased subjects in combination with mechanistic studies using animal models - including various transgenic approaches.
We seek to adapt state of art technologies in our analyses-tool box - including various omics platforms. Further, we seek to gain insight at the single muscle fiber level using both biochemistry and imaging techniques.
In collaborations with various clinical laboratories and pharma industries we aim to translate our findings into relevance for patients and society.
We believe that by illuminating the mechanism by which physical activity promotes health we will be able pointing toward pharmacological interventions eliciting the same healthy beneficial effects as exercise.
Head of research group
Professor Jørgen Wojtaszewski