PhD defence: Improving time- and cost-efficiency in doping analysis

Sara Amalie Solheim is defending her PhD thesis

Improving time- and cost-efficiency in doping analysis

An Industrial PhD project with Anti Doping Denmark

Time

7 February 2020, 14:00

Place

Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen

Opponents

Associate professor Thomas Elbenhardt Jensen (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Head of Science and Testing Programmes Jenny Schulze, The Swedish National Anti-Doping Organisation, Sweden.

Professor Per Aagaard, University of Southern Denmark, Denmark.

Supervisor

Associate professor Nikolai Baastrup Nordsborg, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Co-supervisors

Scientific senior consultant, Dr. Jakob Sehested Mørkeberg, Anti Doping Denmark, Denmark.

Laboratory Director, Dr. Yvette Dehnes, Norwegian Doping Control Laboratory, Oslo University Hospital, Norway.

About the thesis

Testosterone esters and clenbuterol are among the most frequently used doping substances in elite and recreational sports. Detection in urine and blood samples is limited by the costs of collection, transportation and analysis, and the rapid degradation of testosterone esters in blood.

This Industrial PhD thesis aimed to improve the cost-effectiveness of anti-doping testing through the evaluation of

  1. the applicability of a complementary sample collection matrix; dried blood spots (DBS) and
  2. whether the 'blood module' in the 'Athlete Biological Passport' (ABP) can be used to indicate testosterone doping and thereby improve detection, given the stimulating effect of testosterone on red blood cell production, and
  3. by providing concrete suggestions for the anti-doping testing program based on detection periods and performance-enhancing effects.

Download the entire thesis excl. articles.

Download thesis Table of contents; List of papers; Abstract; Resumé (Danish); Introduction.

2020, 154 pages