PhD defence - Annette Karen Lundbeck Serup
Annette Karen Lundbeck Serup is defending her PhD thesis
Lipolysis in Skeletal Muscle
- Regulation and Insulin Sensitiviy
5 May 2017, 14:00
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Associate professor Nikolai Nordsborg (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Professor Gregory R. Steinberg, McMaster University, Canada
Co-director Cedric Moro, The Obesity Research Laboratory, INSERM, Frankring
Professor Bente Kiens, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
About the thesis
Fat is stored in skeletal muscle as intramuscular triacylglycerol (IMTG). IMTG is utilized by lipolysis during situations with low cellular energy availability, such as exercise. The energy sensor AMPK is associated with regulation of lipolysis, however, whether AMPK is an activator or inhibitor of lipolysis in skeletal muscle is not clear. Results from this PhD thesis shows that AMPK is an important activator of lipolysis during muscle contractions by phosphorylating the lipases ATGL and HSL.
Dysregulation of lipolysis results in accumulation of DAG and DAG is associated with impaired insulin sensitivity in skeletal muscles, however not all studies can detect this association between DAG accumulation and impaired insulin sensitivity. DAG exists in different chemical structures depending on how it is generated, and has different reactivity. Thus, the role of DAG in impaired insulin sensitivity in skeletal muscle may be dependent on the chemical structure of DAG. Results from this PhD thesis shows that DAG accumulation originating from dysregulation of lipolysis is not an important signaling molecule in impaired insulin sensitivity in skeletal muscle.
- Table of Content
- List of papers included in the thesis
- List of papers published during the PhD
- Aim and Hypothesis
2017, 189 pages.