PhD defence - Annemarie Lundsgaard
Annemarie Lundsgaard is defending her PhD thesis
Dietary fat - insulin sensitivity and molecular substrate metabolism
16 June 2017, 14:00
Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Associate professor Nikolai Nordsborg (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
Professor Anna Krook, Karolinska Institute, Sweden
Professor Ellen E Blaak, Maastricht University, Holland
Professor Bente Kiens, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
About the thesis
In the present thesis, insulin sensitivity and molecular metabolism was investigated after three days intake of unsaturated fat (78 E%) under conditions of energy surplus. The insulin-stimulated glucose uptake was reduced, which was related to an increased fat oxidation rather than defective insulin signaling. Three days high intake of carbohydrates did in contrast increase glucose oxidation, and hence glucose uptake. It was furthermore found that insulin sensitivity was unchanged when healthy subjects ingested an unsaturated or saturated high-fat diet (64 E%) for six weeks, when energy intake matched energy requirements. An increased uptake and oxidation of fat in skeletal muscle, together with a reduced synthesis of new fatty acids in the liver, contributed to the handling of the high dietary fat load. Hepatic glucose production was notably changed in a non-diabetic direction in both studies under conditions of high fat and low carbohydrate intake.
2017, 179 pages.