PhD defence: Renal function and vitamin D level in HIV positive adults in Ethiopia

Daniel Yilma Bogale is defending his PhD thesis

Renal function and vitamin D level in HIV positive adults in Ethiopia: the effect of antiretroviral treatment and nutrition

Time

9 December 2019, 13:00

Place

Festauditoriet 1-01, Bülowsvej 17.
1870 Frederiksberg C

Opponents 

Professor Anders Sjödin, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

Professor Per Björkman, Clinical Infection Medicine, Lund University, Sweden.

Dr Lene Ryom Nielsen, Department of Infectious Diseases, Hvidovre Hospital, Denmark.

Main supervisor

Professor Henrik Friis, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Co-supervisors

Professor Åse B Andersen, Department of Infectious Diseases, Rigshospitalet, Copenhagen and Research Unit of Infectious Diseases, Department of Clinical Research, University of Southern Denmark, Denmark.

Professor Ole Kirk, Department of Infectious Diseases, Rigshospitalet, Copenhagen and Research Unit of Infectious Diseases, Department of Clinical Research, University of Southern Denmark, Denmark.

About the thesis

Limited information is available on the effect of nutritional supplementation on serum 25-hydroxyvitamin D (25(OH)D) level in HIV positive adults living in sub-Saharan Africa where there is sunshine throughout the year. Moreover, estimated glomerular filtration rate estimating (eGFR) equations using serum creatinine are not validated in most African settings and various results have been reported on the effect of antiretroviral treatment (ART) on kidney function.

In this PhD thesis, use of nutritional supplementation which contained vitamin D prevented a reduction in serum 25 (OH) D levels in HIV positive persons initiating ART. All eGFR equations overestimated 24-hr creatinine clearance in the HIV positive persons. Moreover, HIV positive adults had relatively good kidney function at the initiation of ART in Ethiopia and remained stable over 12 months of ART with no significant difference in HIV positive persons treated with tenofovir disoproxil fumarate (TDF) and non TDF-based regimen.

2019, 151 pages.

The thesis is available for inspection at the library, Nørre Allé 51, DK-2200 Copenhagen N.