TY - JOUR

T1 - Weight loss following an intensive dietary weight loss program in obese candidates for bariatric surgery

T2 - The retrospective RNPC® cohort

AU - Nielsen, Mette Søndergaard

AU - Sjödin, Anders Mikael

AU - Fabre, Odile

AU - Legrand, Rémy

AU - Astrup, Arne

AU - Hjorth, Mads Fiil

N1 - CURIS 2019 NEXS 287

PY - 2019

Y1 - 2019

N2 - Aim: Bariatric surgery is the most effective treatment for obesity. However, less than 1% of eligible patients undergo bariatric surgery annually. Here we evaluated the weight loss effectiveness of an intensive non-surgical weight loss program in patients that would qualify for bariatric surgery. Methods: Patients eligible for bariatric surgery (n = 1460) (BMI≥40 or BMI≥35 kg/m2 plus comorbidities) who were enrolled in a dietary weight loss intervention, the RNPC® program, were compared to a cohort of bariatric surgery patients in terms of weight loss outcome. Results: The 663 patients completing the RNPC® program (35% dropout and 20% ongoing) lost 20.2 ± 11.8 kg corresponding to a reduction of 47% of the excess weight and a percentage weight loss from the initial weight of 18% after a mean period of 18.6 ± 9.1 months. Weight loss 18 months after bariatric surgery (n = 61) was 42.5 ± 15.8 kg corresponding to a reduction of 74% of excess weight and a percentage weight loss from the initial weight of 32%. Conclusion: Although bariatric surgery results in a more pronounced weight loss, a clinically important weight loss can be obtained in patients that would qualify for bariatric surgery following an intensive non-surgical weight loss program. This retrospective analysis calls for randomized trials that compare the long-term cost-effectiveness between the RNPC® program and bariatric surgery.

AB - Aim: Bariatric surgery is the most effective treatment for obesity. However, less than 1% of eligible patients undergo bariatric surgery annually. Here we evaluated the weight loss effectiveness of an intensive non-surgical weight loss program in patients that would qualify for bariatric surgery. Methods: Patients eligible for bariatric surgery (n = 1460) (BMI≥40 or BMI≥35 kg/m2 plus comorbidities) who were enrolled in a dietary weight loss intervention, the RNPC® program, were compared to a cohort of bariatric surgery patients in terms of weight loss outcome. Results: The 663 patients completing the RNPC® program (35% dropout and 20% ongoing) lost 20.2 ± 11.8 kg corresponding to a reduction of 47% of the excess weight and a percentage weight loss from the initial weight of 18% after a mean period of 18.6 ± 9.1 months. Weight loss 18 months after bariatric surgery (n = 61) was 42.5 ± 15.8 kg corresponding to a reduction of 74% of excess weight and a percentage weight loss from the initial weight of 32%. Conclusion: Although bariatric surgery results in a more pronounced weight loss, a clinically important weight loss can be obtained in patients that would qualify for bariatric surgery following an intensive non-surgical weight loss program. This retrospective analysis calls for randomized trials that compare the long-term cost-effectiveness between the RNPC® program and bariatric surgery.

KW - Bariatric surgery

KW - Diet

KW - Obesity

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=85070651542&partnerID=8YFLogxK

U2 - 10.1016/j.obmed.2019.100127

DO - 10.1016/j.obmed.2019.100127

M3 - Journal article

AN - SCOPUS:85070651542

VL - 15

JO - Obesity Medicine

JF - Obesity Medicine

SN - 2451-8476

M1 - 100127

ER -