Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle

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Standard

Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. / Kristensen, Jonas Møller; Treebak, Jonas Thue; Schjerling, Peter; Goodyear, Laurie; Wojtaszewski, Jorgen F P; Wojtaszewski, Jørgen.

I: American Journal of Physiology: Endocrinology and Metabolism, Bind 306, Nr. 10, 2014, s. E1099-E1109.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kristensen, JM, Treebak, JT, Schjerling, P, Goodyear, L, Wojtaszewski, JFP & Wojtaszewski, J 2014, 'Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle', American Journal of Physiology: Endocrinology and Metabolism, bind 306, nr. 10, s. E1099-E1109. https://doi.org/10.1152/ajpendo.00417.2013

APA

Kristensen, J. M., Treebak, J. T., Schjerling, P., Goodyear, L., Wojtaszewski, J. F. P., & Wojtaszewski, J. (2014). Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. American Journal of Physiology: Endocrinology and Metabolism, 306(10), E1099-E1109. https://doi.org/10.1152/ajpendo.00417.2013

Vancouver

Kristensen JM, Treebak JT, Schjerling P, Goodyear L, Wojtaszewski JFP, Wojtaszewski J. Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. American Journal of Physiology: Endocrinology and Metabolism. 2014;306(10):E1099-E1109. https://doi.org/10.1152/ajpendo.00417.2013

Author

Kristensen, Jonas Møller ; Treebak, Jonas Thue ; Schjerling, Peter ; Goodyear, Laurie ; Wojtaszewski, Jorgen F P ; Wojtaszewski, Jørgen. / Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. I: American Journal of Physiology: Endocrinology and Metabolism. 2014 ; Bind 306, Nr. 10. s. E1099-E1109.

Bibtex

@article{03ec557da51941f4a7faac9e363eba71,
title = "Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle",
abstract = "Background: Metformin-induced activation of AMPK has been associated with enhanced glucose uptake in skeletal muscle but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles is dependent upon AMPK signaling. Methods: Oral doses of metformin or saline treatment were given muscle-specific kinase α2 dead AMPK mice (KD) and wild type (WT) littermates either once or chronically for 2 weeks. Soleus and Extensor Digitorum Longus (EDL) muscles were used for measurements of glucose transport and Western blot analyzes. Results: Chronic treatment with metformin enhanced insulin-stimulated glucose uptake in soleus muscles of WT (45{\%}, P",
author = "Kristensen, {Jonas M{\o}ller} and Treebak, {Jonas Thue} and Peter Schjerling and Laurie Goodyear and Wojtaszewski, {Jorgen F P} and J{\o}rgen Wojtaszewski",
note = "CURSI 2014 NEXS 096",
year = "2014",
doi = "10.1152/ajpendo.00417.2013",
language = "English",
volume = "306",
pages = "E1099--E1109",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "10",

}

RIS

TY - JOUR

T1 - Two weeks of metformin treatment induces AMPK dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle

AU - Kristensen, Jonas Møller

AU - Treebak, Jonas Thue

AU - Schjerling, Peter

AU - Goodyear, Laurie

AU - Wojtaszewski, Jorgen F P

AU - Wojtaszewski, Jørgen

N1 - CURSI 2014 NEXS 096

PY - 2014

Y1 - 2014

N2 - Background: Metformin-induced activation of AMPK has been associated with enhanced glucose uptake in skeletal muscle but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles is dependent upon AMPK signaling. Methods: Oral doses of metformin or saline treatment were given muscle-specific kinase α2 dead AMPK mice (KD) and wild type (WT) littermates either once or chronically for 2 weeks. Soleus and Extensor Digitorum Longus (EDL) muscles were used for measurements of glucose transport and Western blot analyzes. Results: Chronic treatment with metformin enhanced insulin-stimulated glucose uptake in soleus muscles of WT (45%, P

AB - Background: Metformin-induced activation of AMPK has been associated with enhanced glucose uptake in skeletal muscle but so far no direct causality has been examined. We hypothesized that an effect of in vivo metformin treatment on glucose uptake in mouse skeletal muscles is dependent upon AMPK signaling. Methods: Oral doses of metformin or saline treatment were given muscle-specific kinase α2 dead AMPK mice (KD) and wild type (WT) littermates either once or chronically for 2 weeks. Soleus and Extensor Digitorum Longus (EDL) muscles were used for measurements of glucose transport and Western blot analyzes. Results: Chronic treatment with metformin enhanced insulin-stimulated glucose uptake in soleus muscles of WT (45%, P

U2 - 10.1152/ajpendo.00417.2013

DO - 10.1152/ajpendo.00417.2013

M3 - Journal article

C2 - 24644243

VL - 306

SP - E1099-E1109

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 10

ER -

ID: 105487526