Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle

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Standard

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. / Koh, Ho-Jin; Toyoda, Taro; Fujii, Nobuharu; Jung, Michelle M.; Rathod, Amee; Middelbeek, R. Jan-Willem; Lessard, Sarah J.; Treebak, Jonas Thue; Tsuchihara, Katsuya; Esumi, Hiroyasu; Richter, Erik A.; Wojtaszewski, Jørgen; Hirshman, Michael F.; Goodyear, Laurie J.

I: Proceedings of the National Academy of Science of the United States of America, Bind 107, Nr. 35, 2010, s. 15541-15546.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Koh, H-J, Toyoda, T, Fujii, N, Jung, MM, Rathod, A, Middelbeek, RJ-W, Lessard, SJ, Treebak, JT, Tsuchihara, K, Esumi, H, Richter, EA, Wojtaszewski, J, Hirshman, MF & Goodyear, LJ 2010, 'Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle', Proceedings of the National Academy of Science of the United States of America, bind 107, nr. 35, s. 15541-15546. https://doi.org/10.1073/pnas.1008131107

APA

Koh, H-J., Toyoda, T., Fujii, N., Jung, M. M., Rathod, A., Middelbeek, R. J-W., Lessard, S. J., Treebak, J. T., Tsuchihara, K., Esumi, H., Richter, E. A., Wojtaszewski, J., Hirshman, M. F., & Goodyear, L. J. (2010). Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proceedings of the National Academy of Science of the United States of America, 107(35), 15541-15546. https://doi.org/10.1073/pnas.1008131107

Vancouver

Koh H-J, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ-W o.a. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proceedings of the National Academy of Science of the United States of America. 2010;107(35):15541-15546. https://doi.org/10.1073/pnas.1008131107

Author

Koh, Ho-Jin ; Toyoda, Taro ; Fujii, Nobuharu ; Jung, Michelle M. ; Rathod, Amee ; Middelbeek, R. Jan-Willem ; Lessard, Sarah J. ; Treebak, Jonas Thue ; Tsuchihara, Katsuya ; Esumi, Hiroyasu ; Richter, Erik A. ; Wojtaszewski, Jørgen ; Hirshman, Michael F. ; Goodyear, Laurie J. / Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. I: Proceedings of the National Academy of Science of the United States of America. 2010 ; Bind 107, Nr. 35. s. 15541-15546.

Bibtex

@article{5dd90390c19711df825b000ea68e967b,
title = "Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle",
abstract = "The signaling mechanisms that mediate the important effects of contraction to increase glucose transport in skeletal muscle are not well understood, but are known to occur through an insulin-independent mechanism. Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated glucose transport. This finding, in conjunction with previous studies of ablated AMPKalpha2 activity showing no effect on contraction-stimulated glucose transport, suggests that one or more AMPK-related protein kinases are important for this process. Muscle contraction increased sucrose nonfermenting AMPK-related kinase (SNARK) activity, an effect blunted in the muscle-specific LKB1 knockout mice. Expression of a mutant SNARK in mouse tibialis anterior muscle impaired contraction-stimulated, but not insulin-stimulated, glucose transport. Whole-body SNARK heterozygotic knockout mice also had impaired contraction-stimulated glucose transport in skeletal muscle, and knockdown of SNARK in C2C12 muscle cells impaired sorbitol-stimulated glucose transport. SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.",
author = "Ho-Jin Koh and Taro Toyoda and Nobuharu Fujii and Jung, {Michelle M.} and Amee Rathod and Middelbeek, {R. Jan-Willem} and Lessard, {Sarah J.} and Treebak, {Jonas Thue} and Katsuya Tsuchihara and Hiroyasu Esumi and Richter, {Erik A.} and J{\o}rgen Wojtaszewski and Hirshman, {Michael F.} and Goodyear, {Laurie J.}",
note = "CURIS 2010 5200 103",
year = "2010",
doi = "10.1073/pnas.1008131107",
language = "English",
volume = "107",
pages = "15541--15546",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "35",

}

RIS

TY - JOUR

T1 - Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle

AU - Koh, Ho-Jin

AU - Toyoda, Taro

AU - Fujii, Nobuharu

AU - Jung, Michelle M.

AU - Rathod, Amee

AU - Middelbeek, R. Jan-Willem

AU - Lessard, Sarah J.

AU - Treebak, Jonas Thue

AU - Tsuchihara, Katsuya

AU - Esumi, Hiroyasu

AU - Richter, Erik A.

AU - Wojtaszewski, Jørgen

AU - Hirshman, Michael F.

AU - Goodyear, Laurie J.

N1 - CURIS 2010 5200 103

PY - 2010

Y1 - 2010

N2 - The signaling mechanisms that mediate the important effects of contraction to increase glucose transport in skeletal muscle are not well understood, but are known to occur through an insulin-independent mechanism. Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated glucose transport. This finding, in conjunction with previous studies of ablated AMPKalpha2 activity showing no effect on contraction-stimulated glucose transport, suggests that one or more AMPK-related protein kinases are important for this process. Muscle contraction increased sucrose nonfermenting AMPK-related kinase (SNARK) activity, an effect blunted in the muscle-specific LKB1 knockout mice. Expression of a mutant SNARK in mouse tibialis anterior muscle impaired contraction-stimulated, but not insulin-stimulated, glucose transport. Whole-body SNARK heterozygotic knockout mice also had impaired contraction-stimulated glucose transport in skeletal muscle, and knockdown of SNARK in C2C12 muscle cells impaired sorbitol-stimulated glucose transport. SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

AB - The signaling mechanisms that mediate the important effects of contraction to increase glucose transport in skeletal muscle are not well understood, but are known to occur through an insulin-independent mechanism. Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated glucose transport. This finding, in conjunction with previous studies of ablated AMPKalpha2 activity showing no effect on contraction-stimulated glucose transport, suggests that one or more AMPK-related protein kinases are important for this process. Muscle contraction increased sucrose nonfermenting AMPK-related kinase (SNARK) activity, an effect blunted in the muscle-specific LKB1 knockout mice. Expression of a mutant SNARK in mouse tibialis anterior muscle impaired contraction-stimulated, but not insulin-stimulated, glucose transport. Whole-body SNARK heterozygotic knockout mice also had impaired contraction-stimulated glucose transport in skeletal muscle, and knockdown of SNARK in C2C12 muscle cells impaired sorbitol-stimulated glucose transport. SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.

U2 - 10.1073/pnas.1008131107

DO - 10.1073/pnas.1008131107

M3 - Journal article

C2 - 20713714

VL - 107

SP - 15541

EP - 15546

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 35

ER -

ID: 22021191