Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Skeletal muscle glucose uptake during dynamic exercise in humans : role of muscle mass. / Richter, Erik A.; Kiens, Bente; Saltin, Bengt; Christensen, N J; Savard, G.

I: American Journal of Physiology (Consolidated), Bind 254, Nr. 5 Pt 1, 1988, s. E555-E561.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Richter, EA, Kiens, B, Saltin, B, Christensen, NJ & Savard, G 1988, 'Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass', American Journal of Physiology (Consolidated), bind 254, nr. 5 Pt 1, s. E555-E561.

APA

Richter, E. A., Kiens, B., Saltin, B., Christensen, N. J., & Savard, G. (1988). Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. American Journal of Physiology (Consolidated), 254(5 Pt 1), E555-E561.

Vancouver

Richter EA, Kiens B, Saltin B, Christensen NJ, Savard G. Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. American Journal of Physiology (Consolidated). 1988;254(5 Pt 1):E555-E561.

Author

Richter, Erik A. ; Kiens, Bente ; Saltin, Bengt ; Christensen, N J ; Savard, G. / Skeletal muscle glucose uptake during dynamic exercise in humans : role of muscle mass. I: American Journal of Physiology (Consolidated). 1988 ; Bind 254, Nr. 5 Pt 1. s. E555-E561.

Bibtex

@article{ca2b49fe5778485ba2b5d51b9cee4044,
title = "Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass",
abstract = "To study the role of muscle mass in glucoregulation, six subjects worked with the knee extensors of one leg on a specially constructed cycle ergometer. The knee extensors of one leg worked either alone or in combination with the knee extensors of the other leg and/or with the arms. Substrate usage was measured across both knee extensors by femoral arterial and venous catheterization and measurement of femoral venous blood flow. Glucose uptake by the working knee extensors was absolutely (by approximately 20%) or relatively decreased when arm cranking was added to knee extensions. The decrease in glucose uptake was not compensated for by increased uptake of free fatty acids but was accompanied by decreases in plasma insulin and increases in plasma epinephrine and norepinephrine. During work with large muscle masses, arterial lactate increased to approximately 6 mM, and net leg lactate release reverted to net lactate uptake. Decreased glucose uptake could not be explained by decreased perfusion. It is concluded that thigh muscle glucose uptake is affected by the size of the total muscle mass engaged in exercise. The decrease in thigh glucose uptake, when arm cranking was added and O2 uptake was increased above 50% of maximum aerobic capacity, may be elicited by neuroendocrine adjustments or lactate-induced inhibition of glycolysis and may represent a mechanism for protecting against premature hypoglycemia during prolonged exercise.",
keywords = "Adult, Epinephrine, Fatty Acids, Nonesterified, Glucose, Humans, Insulin, Lactates, Lactic Acid, Male, Muscles, Norepinephrine, Oxygen Consumption, Physical Exertion, Thigh",
author = "Richter, {Erik A.} and Bente Kiens and Bengt Saltin and Christensen, {N J} and G Savard",
year = "1988",
language = "English",
volume = "254",
pages = "E555--E561",
journal = "American Journal of Physiology - Cell Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "5 Pt 1",

}

RIS

TY - JOUR

T1 - Skeletal muscle glucose uptake during dynamic exercise in humans

T2 - role of muscle mass

AU - Richter, Erik A.

AU - Kiens, Bente

AU - Saltin, Bengt

AU - Christensen, N J

AU - Savard, G

PY - 1988

Y1 - 1988

N2 - To study the role of muscle mass in glucoregulation, six subjects worked with the knee extensors of one leg on a specially constructed cycle ergometer. The knee extensors of one leg worked either alone or in combination with the knee extensors of the other leg and/or with the arms. Substrate usage was measured across both knee extensors by femoral arterial and venous catheterization and measurement of femoral venous blood flow. Glucose uptake by the working knee extensors was absolutely (by approximately 20%) or relatively decreased when arm cranking was added to knee extensions. The decrease in glucose uptake was not compensated for by increased uptake of free fatty acids but was accompanied by decreases in plasma insulin and increases in plasma epinephrine and norepinephrine. During work with large muscle masses, arterial lactate increased to approximately 6 mM, and net leg lactate release reverted to net lactate uptake. Decreased glucose uptake could not be explained by decreased perfusion. It is concluded that thigh muscle glucose uptake is affected by the size of the total muscle mass engaged in exercise. The decrease in thigh glucose uptake, when arm cranking was added and O2 uptake was increased above 50% of maximum aerobic capacity, may be elicited by neuroendocrine adjustments or lactate-induced inhibition of glycolysis and may represent a mechanism for protecting against premature hypoglycemia during prolonged exercise.

AB - To study the role of muscle mass in glucoregulation, six subjects worked with the knee extensors of one leg on a specially constructed cycle ergometer. The knee extensors of one leg worked either alone or in combination with the knee extensors of the other leg and/or with the arms. Substrate usage was measured across both knee extensors by femoral arterial and venous catheterization and measurement of femoral venous blood flow. Glucose uptake by the working knee extensors was absolutely (by approximately 20%) or relatively decreased when arm cranking was added to knee extensions. The decrease in glucose uptake was not compensated for by increased uptake of free fatty acids but was accompanied by decreases in plasma insulin and increases in plasma epinephrine and norepinephrine. During work with large muscle masses, arterial lactate increased to approximately 6 mM, and net leg lactate release reverted to net lactate uptake. Decreased glucose uptake could not be explained by decreased perfusion. It is concluded that thigh muscle glucose uptake is affected by the size of the total muscle mass engaged in exercise. The decrease in thigh glucose uptake, when arm cranking was added and O2 uptake was increased above 50% of maximum aerobic capacity, may be elicited by neuroendocrine adjustments or lactate-induced inhibition of glycolysis and may represent a mechanism for protecting against premature hypoglycemia during prolonged exercise.

KW - Adult

KW - Epinephrine

KW - Fatty Acids, Nonesterified

KW - Glucose

KW - Humans

KW - Insulin

KW - Lactates

KW - Lactic Acid

KW - Male

KW - Muscles

KW - Norepinephrine

KW - Oxygen Consumption

KW - Physical Exertion

KW - Thigh

M3 - Journal article

C2 - 3284382

VL - 254

SP - E555-E561

JO - American Journal of Physiology - Cell Physiology

JF - American Journal of Physiology - Cell Physiology

SN - 0363-6143

IS - 5 Pt 1

ER -

ID: 154757622