TY - JOUR

T1 - Serum alpha-fetoprotein and alcohol consumption

AU - Christiansen, Michael

AU - Andersen, Jens Rikardt

AU - Tørning, J.

AU - Overgård, Ove

AU - Jensen, S P

AU - Magid, E

AU - Nørgaard-Pedersen, B

N1 - (Eksterne)

PY - 1994

Y1 - 1994

N2 - Fifty-nine persons, 23 chronic alcoholics and 36 normal healthy persons with a well described alcohol consumption, had the serum concentration of alpha-fetoprotein determined by a sensitive monoclonal immunofluorescent assay. A significant elevation in S-AFP was found in alcoholics, median 4.1 kIU/1 as compared to 3.0kIU/l in near-abstainers (<12g ethanol per day) (p<0.02). This difference was not explained by differences in age. S-AFP correlated positively with age (p = 0.01). In non-alcoholics a borderline significant correlation with S-AFP was found with average daily alcohol consumption (self-reported) (p = 0.09) and a significant correlation with the serum concentration of carbohydrate-deficient transferrin (S-CDT) (p = 0.004). In 11 alcoholics 2 months of abstention from alcohol was accompanied by a median reduction of 21% in S-AFP (p < 10-5). In alcoholics, but not in social drinkers, S-AFP correlated with S-ASAT (p = 0.004). The increase of S-AFP with alcohol consumption may reflect reversible alcohol-induced liver affection.

AB - Fifty-nine persons, 23 chronic alcoholics and 36 normal healthy persons with a well described alcohol consumption, had the serum concentration of alpha-fetoprotein determined by a sensitive monoclonal immunofluorescent assay. A significant elevation in S-AFP was found in alcoholics, median 4.1 kIU/1 as compared to 3.0kIU/l in near-abstainers (<12g ethanol per day) (p<0.02). This difference was not explained by differences in age. S-AFP correlated positively with age (p = 0.01). In non-alcoholics a borderline significant correlation with S-AFP was found with average daily alcohol consumption (self-reported) (p = 0.09) and a significant correlation with the serum concentration of carbohydrate-deficient transferrin (S-CDT) (p = 0.004). In 11 alcoholics 2 months of abstention from alcohol was accompanied by a median reduction of 21% in S-AFP (p < 10-5). In alcoholics, but not in social drinkers, S-AFP correlated with S-ASAT (p = 0.004). The increase of S-AFP with alcohol consumption may reflect reversible alcohol-induced liver affection.

KW - Alcohol

KW - Alcoholic liver disease

KW - Alpha-fetoprotein

KW - Carbohydrate-deficient transferrin

UR - http://www.scopus.com/inward/record.url?scp=0027930189&partnerID=8YFLogxK

U2 - 10.3109/00365519409088427

DO - 10.3109/00365519409088427

M3 - Journal article

C2 - 7518611

AN - SCOPUS:0027930189

VL - 54

SP - 215

EP - 220

JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement

JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement

SN - 0085-591X

IS - 3

ER -