Route of administration of pentobarbital affects activity of liver glycogen phosphorylase

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Route of administration of pentobarbital affects activity of liver glycogen phosphorylase. / Mikines, K J; Sonne, B; Richter, Erik A.; Galbo, H.

I: Journal of Applied Physiology, Bind 61, Nr. 2, 1986, s. 804-806.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mikines, KJ, Sonne, B, Richter, EA & Galbo, H 1986, 'Route of administration of pentobarbital affects activity of liver glycogen phosphorylase', Journal of Applied Physiology, bind 61, nr. 2, s. 804-806.

APA

Mikines, K. J., Sonne, B., Richter, E. A., & Galbo, H. (1986). Route of administration of pentobarbital affects activity of liver glycogen phosphorylase. Journal of Applied Physiology, 61(2), 804-806.

Vancouver

Mikines KJ, Sonne B, Richter EA, Galbo H. Route of administration of pentobarbital affects activity of liver glycogen phosphorylase. Journal of Applied Physiology. 1986;61(2):804-806.

Author

Mikines, K J ; Sonne, B ; Richter, Erik A. ; Galbo, H. / Route of administration of pentobarbital affects activity of liver glycogen phosphorylase. I: Journal of Applied Physiology. 1986 ; Bind 61, Nr. 2. s. 804-806.

Bibtex

@article{0a0846ad8a52472b9f1a2f71308600f4,
title = "Route of administration of pentobarbital affects activity of liver glycogen phosphorylase",
abstract = "Liver phosphorylase a activity in intact animals is mostly determined during anesthesia. The aim of this study was to investigate the effect of administering pentobarbital by different routes on activity of liver phosphorylase a. Rats had chronically implanted venous catheters and received pentobarbital (5 mg/100 g body wt) either intraperitoneally, as a slow intravenous infusion, or as an intravenous or intracardial bolus. Times from administration of barbiturate to sampling of the liver were 10 min, 10 min, 85 +/- 32 s (mean +/- SE), and 53 +/- 10 s, respectively. Phosphorylase a activity in % of total phosphorylase activity was 40 +/- 2, 56 +/- 4, 82 +/- 3, and 92 +/- 2, respectively, all significantly different. Thus the route of administration of pentobarbital affects the phosphorylase a activity and should be considered when evaluating this activity. This fact can only be partially explained by differences in duration before the drug takes effect. It is proposed that intraperitoneal injection of pentobarbital may anesthetize hepatic sympathetic nerves or have a direct inhibiting effect on phosphorylase a activity.",
keywords = "Animals, Heart, Infusions, Parenteral, Injections, Injections, Intraperitoneal, Injections, Intravenous, Liver, Male, Pentobarbital, Phosphorylases, Rats",
author = "Mikines, {K J} and B Sonne and Richter, {Erik A.} and H Galbo",
year = "1986",
language = "English",
volume = "61",
pages = "804--806",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Route of administration of pentobarbital affects activity of liver glycogen phosphorylase

AU - Mikines, K J

AU - Sonne, B

AU - Richter, Erik A.

AU - Galbo, H

PY - 1986

Y1 - 1986

N2 - Liver phosphorylase a activity in intact animals is mostly determined during anesthesia. The aim of this study was to investigate the effect of administering pentobarbital by different routes on activity of liver phosphorylase a. Rats had chronically implanted venous catheters and received pentobarbital (5 mg/100 g body wt) either intraperitoneally, as a slow intravenous infusion, or as an intravenous or intracardial bolus. Times from administration of barbiturate to sampling of the liver were 10 min, 10 min, 85 +/- 32 s (mean +/- SE), and 53 +/- 10 s, respectively. Phosphorylase a activity in % of total phosphorylase activity was 40 +/- 2, 56 +/- 4, 82 +/- 3, and 92 +/- 2, respectively, all significantly different. Thus the route of administration of pentobarbital affects the phosphorylase a activity and should be considered when evaluating this activity. This fact can only be partially explained by differences in duration before the drug takes effect. It is proposed that intraperitoneal injection of pentobarbital may anesthetize hepatic sympathetic nerves or have a direct inhibiting effect on phosphorylase a activity.

AB - Liver phosphorylase a activity in intact animals is mostly determined during anesthesia. The aim of this study was to investigate the effect of administering pentobarbital by different routes on activity of liver phosphorylase a. Rats had chronically implanted venous catheters and received pentobarbital (5 mg/100 g body wt) either intraperitoneally, as a slow intravenous infusion, or as an intravenous or intracardial bolus. Times from administration of barbiturate to sampling of the liver were 10 min, 10 min, 85 +/- 32 s (mean +/- SE), and 53 +/- 10 s, respectively. Phosphorylase a activity in % of total phosphorylase activity was 40 +/- 2, 56 +/- 4, 82 +/- 3, and 92 +/- 2, respectively, all significantly different. Thus the route of administration of pentobarbital affects the phosphorylase a activity and should be considered when evaluating this activity. This fact can only be partially explained by differences in duration before the drug takes effect. It is proposed that intraperitoneal injection of pentobarbital may anesthetize hepatic sympathetic nerves or have a direct inhibiting effect on phosphorylase a activity.

KW - Animals

KW - Heart

KW - Infusions, Parenteral

KW - Injections

KW - Injections, Intraperitoneal

KW - Injections, Intravenous

KW - Liver

KW - Male

KW - Pentobarbital

KW - Phosphorylases

KW - Rats

M3 - Journal article

C2 - 3745074

VL - 61

SP - 804

EP - 806

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -

ID: 154758199