Regulation of skeletal muscle glycogenolysis during exercise
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Regulation of skeletal muscle glycogenolysis during exercise. / Hargreaves, M; Richter, Erik A.
I: Canadian Journal of Sport Sciences, Bind 13, Nr. 4, 1988, s. 197-203.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Regulation of skeletal muscle glycogenolysis during exercise
AU - Hargreaves, M
AU - Richter, Erik A.
PY - 1988
Y1 - 1988
N2 - Muscle-glycogen breakdown during exercise is influenced by both local and systemic factors. Contractions per se increase glycogenolysis via a calcium-induced, transient increase in the activity of phosphorylase a, and probably also via increased concentrations of Pi. In fast-twitch muscle, increases in the AMP and IMP levels may increase phosphorylase activity. The rate of muscle-glycogen breakdown during exercise depends on the pre-exercise glycogen concentration and is also influenced by hormones. Insulin may inhibit glycogen breakdown, whereas epinephrine enhances the rate of glycogen use in contracting muscle by increasing the phosphorylase a activity via increased cyclic AMP production. The availability of blood-borne substrates may also influence muscle glycogenolysis and, therefore, exercise performance.
AB - Muscle-glycogen breakdown during exercise is influenced by both local and systemic factors. Contractions per se increase glycogenolysis via a calcium-induced, transient increase in the activity of phosphorylase a, and probably also via increased concentrations of Pi. In fast-twitch muscle, increases in the AMP and IMP levels may increase phosphorylase activity. The rate of muscle-glycogen breakdown during exercise depends on the pre-exercise glycogen concentration and is also influenced by hormones. Insulin may inhibit glycogen breakdown, whereas epinephrine enhances the rate of glycogen use in contracting muscle by increasing the phosphorylase a activity via increased cyclic AMP production. The availability of blood-borne substrates may also influence muscle glycogenolysis and, therefore, exercise performance.
KW - Blood Glucose
KW - Calcium
KW - Epinephrine
KW - Exercise
KW - Glycogen
KW - Humans
KW - Insulin
KW - Muscles
KW - Phosphorylases
M3 - Review
C2 - 3064902
VL - 13
SP - 197
EP - 203
JO - Canadian Journal of Sport Sciences
JF - Canadian Journal of Sport Sciences
IS - 4
ER -
ID: 154757294