Reflux oesophagitis in heavy drinkers: Effect of ranitidine and alginate/metoclopramide
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Reflux oesophagitis in heavy drinkers : Effect of ranitidine and alginate/metoclopramide. / Tønnesen, Hanne; Andersen, Jens Rikardt; Chrisioffersen, Per; Kaas-Claesson, Niels.
I: Digestion, Bind 38, Nr. 2, 1987, s. 69-73.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Reflux oesophagitis in heavy drinkers
T2 - Effect of ranitidine and alginate/metoclopramide
AU - Tønnesen, Hanne
AU - Andersen, Jens Rikardt
AU - Chrisioffersen, Per
AU - Kaas-Claesson, Niels
N1 - (Ekstern)
PY - 1987
Y1 - 1987
N2 - Of 1, 400 consecutive patients applying to an outpatient clinic for treatment of alcoholism, 477 complained of upper abdominal dyspepsia. After 2 weeks of abstinence, 78 had persisting complaints; of these, 72% had oesophagitis at endoscopy. The 53 patients with oesophagitis as the sole diagnosis were randomized to treatment with either ranitidine or a combination of alginate/antacid chewing tablets and metoclopramide for 6 weeks in a double-blind, double-dummy design. Twenty-five patients left the study during the observation time due to relapse of alcoholism, and were only observed until then. No significant differences were found between the treatment groups concerning the course of symptoms and endoscopic or histological improvement.
AB - Of 1, 400 consecutive patients applying to an outpatient clinic for treatment of alcoholism, 477 complained of upper abdominal dyspepsia. After 2 weeks of abstinence, 78 had persisting complaints; of these, 72% had oesophagitis at endoscopy. The 53 patients with oesophagitis as the sole diagnosis were randomized to treatment with either ranitidine or a combination of alginate/antacid chewing tablets and metoclopramide for 6 weeks in a double-blind, double-dummy design. Twenty-five patients left the study during the observation time due to relapse of alcoholism, and were only observed until then. No significant differences were found between the treatment groups concerning the course of symptoms and endoscopic or histological improvement.
KW - Alcoholism
KW - Alginate
KW - Metoclopramide
KW - Oesophagitis
KW - Ranitidine
UR - http://www.scopus.com/inward/record.url?scp=0023489851&partnerID=8YFLogxK
U2 - 10.1159/000199574
DO - 10.1159/000199574
M3 - Journal article
C2 - 3440508
AN - SCOPUS:0023489851
VL - 38
SP - 69
EP - 73
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 2
ER -
ID: 251991841